Analysis Tools
mortality/aging
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• frequency of natural death within 1.5 years is about 50% higher than in controls
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• frequency of natural death within 1.5 years is about 50% higher than in controls
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behavior/neurological
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• in a shuttlebox avoidance tests, mutants exhibit fewer escape responses than wild-type
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• exploratory behavior is different from wild-type in the presence of social interactions
• in a platform-leaving test, when mutants are paired with a wild-type littermate, mutants leave the elevated platform much more slowly than wild-type mice, while mutants paired with wild-type nonlittermates, leave it on average, more frequently than the wild-type nonlittermates, even though mutants show decreased exploratory behavior when tested alone: authors speculate that mice are socially recessive and when placed with unknown mice, they leave the platform faster to reduce proximity-induced anxiety
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• in the water version of the radial arm maze, mutants make more errors in the acquisition phase than controls
• in the Lashley III maze, mutants are less competent than wild-type mice, as measured by the learning index, T-forward errors, and the total number of backward errors
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• on a hidden platform Morris maze, mutants show normal spatial learning, however 7-8 weeks later, during retention testing, mutants take more time to find the platform and travel a longer distance before reaching it
• 7-8 weeks later after training in the Lashely III maze, mutants have lower scores on the first trial, showing reduced long-term memory retention
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• mutants show a longer retention time on the first day of passive learning, taking longer to enter the dark chamber than wild-type, but a similar level on the second day of learning, most likely indicating increased anxiety to enter new environment
• in a platform-leaving test, when mutants are placed with littermates, they leave the platform slowly, however when placed with nonlittermates, they leave much quicker, presumably to reduce proximity-induced anxiety
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bradykinesia
(
J:62140
)
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• mutants exhibit lower spontaneous activity; they travel less distance, spend more time near the field's center, and spend less time near the walls
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• exploratory behavior is different from wild-type in the presence of social interactions
• in a platform-leaving test, when mutants are placed with littermates, they leave the platform slowly, however when placed with nonlittermates, they leave much quicker, presumably to reduce proximity-induced anxiety
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hematopoietic system
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• mutants show a weaker mitogenic response of splenocytes to phytohemagglutinin
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• mutants show a weaker mitogenic response of thymocytes to phytohemagglutinin
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immune system
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• mutants show a weaker mitogenic response of splenocytes to phytohemagglutinin
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• mutants show a weaker mitogenic response of thymocytes to phytohemagglutinin
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• mutants show hypersensitivity to bacterial lipopolysaccharide
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cellular
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• mutants show a weaker mitogenic response of splenocytes to phytohemagglutinin
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