Phenotypes associated with this allele

• Allele Symbol: Tg(Ela1-Tgfa)150Bri
• Allele Name: transgene insertion 150, Ralph L Brinster
• Allele ID: MGI:2449466
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ela1-Tgfa)150Bri/0 Trp53^tm1Tyj/Trp53^+	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:6192107
cx2	Tg(Ela1-Tgfa)150Bri/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:6192108
tg3	Tg(Ela1-Tgfa)150Bri/0	involves: C57BL/6 * SJL	MGI:6192093

Genotype
MGI:6192107

cx1

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:67389 )

• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days

• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

neoplasm

increased pancreas tumor incidence ( J:67389 )

• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days

• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:67389

Genotype
MGI:6192108

cx2

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

endocrine/exocrine glands

increased pancreas tumor incidence ( J:67389 )

• 100% of mice develop pancreatic tumors within 120 days after birth

increased pancreatic ductal adenocarcinoma incidence ( J:67389 )

• pancreatic carcinomas display a ductal phenotype, grow invasively into surrounding tissue, and metastasize

neoplasm

increased pancreas tumor incidence ( J:67389 )

• 100% of mice develop pancreatic tumors within 120 days after birth

increased pancreatic ductal adenocarcinoma incidence ( J:67389 )

• pancreatic carcinomas display a ductal phenotype, grow invasively into surrounding tissue, and metastasize

increased malignant tumor incidence ( J:67389 )

• pancreatic carcinomas metastasize to liver and lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:67389

Genotype
MGI:6192093

tg3

• Allelic Composition: Tg(Ela1-Tgfa)150Bri/0
• Genetic Background: involves: C57BL/6 * SJL

endocrine/exocrine glands

abnormal pancreas morphology ( J:52757 )

• 12 of 21 mice show dysplastic changes in the pancreas after 1 year of age

• two types of dysplastic changes are seen: highly proliferating tubular complexes and large cystic changes

abnormal pancreatic acinar cell morphology ( J:52757 )

• decrease in acinar cell height starting at P14

increased pancreas tumor incidence ( J:52757 , J:67389 )

• 4 of 21 mice develop malignant pancreatic tumors which are multicentric and originate from dysplastic tubular complexes and display a mixed cystic-papillary phenotype (J:52757)

• 29% of mice develop malignant pancreatic tumors with a mean tumor-free survival of 410 days (J:67389)

pancreas cyst ( J:52757 )

• some mice show large cystic changes in the pancreas

pancreas fibrosis ( J:52757 )

• an increase in interlobular fibroblast population is seen as early as P14 which progresses to massive fibrosis with extensive extracellular matrix accumulation at P180

pancreatic acinar-to-ductal metaplasia ( J:52757 )

• in older mice, acinar cells change to duct-like cells, which form tubular structures and express ductal markers

neoplasm

increased pancreas tumor incidence ( J:52757 , J:67389 )

• 4 of 21 mice develop malignant pancreatic tumors which are multicentric and originate from dysplastic tubular complexes and display a mixed cystic-papillary phenotype (J:52757)

• 29% of mice develop malignant pancreatic tumors with a mean tumor-free survival of 410 days (J:67389)

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:52757 )

• decrease in acinar cell height starting at P14

growth/size/body

pancreas cyst ( J:52757 )

• some mice show large cystic changes in the pancreas