Phenotypes associated with this allele

• Allele Symbol: Tenm4^l7Rn3-4R
• Allele Name: mutation 4, Oak Ridge
• Allele ID: MGI:2449639
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tenm4^l7Rn3-4R/Tenm4^l7Rn3-4R	involves: BALB/cRl * C3H/Rl * C57BL/10Rl	MGI:2449640
cx2	Tenm4^l7Rn3-4R/Tyr^c-26DVT	involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock	MGI:3789295

Genotype
MGI:2449640

hm1

• Allelic Composition: Tenm4^l7Rn3-4R/Tenm4^l7Rn3-4R
• Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:54592 )

• runting of variable penetrance; only about 20% of animals display this phenotype

Genotype
MGI:3789295

cx2

• Allelic Composition: Tenm4^l7Rn3-4R/Tyr^c-26DVT
• Genetic Background: involves: 101/Rl * BALB/cRl * C3H/Rl * C57BL/10Rl * T-stock

mortality/aging

mortality/aging ( J:96673 )

N • when the Odz4^l7Rn3-4R allele is inherited from the father, animals survive to adulthood

prenatal lethality, complete penetrance ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, animals die as embryos between E8.5 and E17.5

cardiovascular system

abnormal vasculogenesis ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, defects in vascularization are seen

embryo

embryonic growth retardation ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen

abnormal limb bud morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, abnormalities in limb bud elongation are seen

kinked neural tube ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed

growth/size/body

embryonic growth retardation ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, developmental delay is seen

decreased body size ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 30% of animals appear runted and scruffy at weaning

limbs/digits/tail

abnormal limb bud morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, abnormalities in limb bud elongation are seen

nervous system

kinked neural tube ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the mother, kinky neural tubes are observed

skeleton

thoracic vertebral fusion ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions

abnormal cervical axis morphology ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, an aberrant spinous process is observed in 18% of mutant animals

lumbar vertebral fusion ( J:96673 )

• when the Odz4^l7Rn3-4R allele is inherited from the father, 27% of mutant animals display lumbar and/or thoracic vertebral fusions