mortality/aging
• mice die within 3 weeks of birth
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Allele Symbol Allele Name Allele ID |
Slc1a2tm1Kta targeted mutation 1, Kohichi Tanaka MGI:2449707 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice die within 3 weeks of birth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only about 50% survive until after 6 weeks of age
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• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
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• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
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• although body weight was normal at birth, homozygous mice gained weight more slowly after birth
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• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
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• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
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• 68% more brain edemas resulting from cold injury and size of edemas are much larger
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• selective neuronal degeneration in the hippocampal CA1 in mice aged 4-8 weeks
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• neuronal loss in the pyramidal layer of CA1 24 hours after brief (5 min) hippocampal ischemia leading to a build up of glutamate concentration
• by 4 days after ischemia, neuronal loss is seen throughout CA1 and CA3
• longer periods of ischemia are as damaging to wild-type mice as to homozygous mutants
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• 68% more brain edemas resulting from cold injury and size of edemas are much larger
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• only have 65% glutamate transport when compared with wild-type mice in lumbar spinal cord and cerebral cortex
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• shortened lifespan (137 1.7 vs. 142 1.4 days)
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• reduced glutamate transport in lumbar spinal cord at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice
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• increase in the rate of motor decline accompanied by earlier motor neuron loss
• accelerated motor neuron loss at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice
• significant declines occur between 105 and 120 days (42% reduction) and between 120 days and end stage, compared with between 120 days and endstage (56%) in Tg(SOD1*G93A)1Gur mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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