Analysis Tools
mortality/aging
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• death at ~ 12 months of age
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behavior/neurological
cellular
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• evident by 14 days of age, most tissues showed vacuolization in specific cells, especially in the reticuloendothelial system, including lymphocytes, macrophages, kidney tubular epithelium (especially evident in proximal tubule, and progressively worse with age) as well as liver hepatocytes and Kupffer cells, spleen (congested with foamy macrophages), and brain, often located around neurons and blood vessels
• pancreas, small and large intestine, lymph nodes, testis, ovaries, uterus, heart, bone marrow, and eye had membrane-bound vacuoles primarily in macrophages and cells of epithelial/endothelial origin
• no evidence of lysosomal storage in lungs, skeletal muscle or megakaryocytes
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craniofacial
growth/size/body
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• weighed 25% - 40% less than littermate controls
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• evident at autopsy
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• evident at autopsy
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hematopoietic system
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• evident at autopsy
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homeostasis/metabolism
immune system
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• evident at autopsy
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liver/biliary system
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• evident at autopsy
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integument
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• deterioration of coat texture accompanied progressive edema and neurological symptoms
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