Analysis Tools
nervous system
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• depression of spontaneous action potential firing due to etomidate or enflurane is less than controls
(J:81497)
• duration of early local field potentials is reduced less than in controls after administration of etomate
(J:105539)
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• 0.2 microM etomate causes only half the neural depression in brain slices from the somatosensory cortex as seen in controls (31% vs 65%)
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• etomidate has less affect on GABA induced chloride currents in hippocampal pyramidal cells
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behavior/neurological
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• motor activity and response to noxious thermal stimuli are normal
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• behavioral responses to anesthetics are reduced relative to controls
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• hind limb withrdrawl reflex is not lost at any dose of etomidate
• responses to volatile anesthetics such as enflurane and halothane are normal
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• duration of the loss of righting reflex after administration of etomidate or propofol is less than for controls
• responses to volatile anesthetics such as enflurane and halothane are normal
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• involuntary muscular contractions and spasms are seen after administration of very low doses of etomidate
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