All Phenotypes Opn4<tm1Yau> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Opn4^tm1Yau/Opn4^tm4(DTA)Saha	involves: 129 * C57BL/6	MGI:3797748
cn2	Opn4^{tm1.1(cre)Saha}/Opn4^tm1Yau Pou4f2^tm4(DTA)Whk/Pou4f2⁺	involves: 129S/SvEv * C57BL/6	MGI:5285915
cx3	Opn1mw^{tm1(OPN1LW)Nat}/Opn1mw^{tm1(OPN1LW)Nat} Opn4^tm1Yau/Opn4^tm1Yau	involves: 129	MGI:5694632
cx4	Cnga3^tm1Biel/Cnga3^tm1Biel Gnat1^tm1Clma/Gnat1^tm1Clma Opn4^tm1Yau/Opn4^tm1Yau	involves: 129 * C57BL/6	MGI:3521969

Allelic Composition	Opn4^tm1Yau/Opn4^tm4(DTA)Saha
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^tm1Yau mutation (0 available); any Opn4 mutation (33 available)
Opn4^tm4(DTA)Saha mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:134780 )

• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

nervous system

abnormal suprachiasmatic nucleus morphology ( J:134780 )

• few fibers innervate the SCN from the retinal ganglion cells

abnormal retina ganglion cell morphology ( J:134780 )

• only 17.1% of retinal ganglion cells expressing melanopsin are present compared to wild-type controls

• there are fewer fiber terminals from the retinal ganglion cells reach into the suprachiasmatic nucleus, the intergeniculate leaflet, and the olivary pretectal nucleus

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4^tm1Yau Pou4f2^tm4(DTA)Whk/Pou4f2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Opn4^tm1Yau mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

• no fibres are observed in the shell of the OPN

abnormal innervation ( J:174940 )

• innervation of the intergeniculate nucleus (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas; these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ ;Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

Allelic Composition	Opn1mw^{tm1(OPN1LW)Nat}/Opn1mw^{tm1(OPN1LW)Nat} Opn4^tm1Yau/Opn4^tm1Yau
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn1mw^{tm1(OPN1LW)Nat} mutation (1 available); any Opn1mw mutation (5 available)
Opn4^tm1Yau mutation (0 available); any Opn4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal visual contrast sensitivity ( J:199509 )

• mice learn to swim toward higher radiance target, green vs red or dim red vs brighter red

• mice no longer distinguish between green and red targets at a higher green radiance level than do mice homozygous only for Opn1mw^{tm1(OPN1LW)Nat}

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired pupillary reflex ( J:84281 )

• triple mutants essentially show no pupillary reflex in response to intense exposure of light at 480 nm, monochromatic light at other wavelengths (360-660 nm) or intense white light

• on close scrutiny, 2 out of 6 triple mutants displayed a small, very transient pupil constriction in response to bright 480-nm light; however, this was not consistently observed on repeated stimulus trials with extensive dark adaptation (up to 3 days) in between

• in contrast, triple mutants exhibit maximum pupil constriction in response to carbachol (a parasympathetic agonist)

shortened circadian behavior period ( J:84281 )

• actograms of wheel running under a 16/8-h light/dark cycle showed that triple mutants free-run with a period of less than 24 hours

abnormal circardian behavior entrainment ( J:84281 )

• triple homozygotes fail to entrain to light/dark cycles and show no masking response to light

vision/eye

vision/eye phenotype ( J:84281 )

N	• triple homozygotes display normal retinal morphology and thickness relative to wild-type mice • also, triple mutants show normal abundance and central connectivity of melanopsin-expressing retinal ganglion cells in brain

impaired pupillary reflex ( J:84281 )

• triple mutants essentially show no pupillary reflex in response to intense exposure of light at 480 nm, monochromatic light at other wavelengths (360-660 nm) or intense white light

• in contrast, triple mutants exhibit maximum pupil constriction in response to carbachol (a parasympathetic agonist)

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