All Phenotypes Kit<tm1Alf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kit^tm1Alf/Kit^tm1Alf	involves: 129S2/SvPas	MGI:3770780
ht2	Kit^tm1Alf/Kit⁺	involves: 129S2/SvPas	MGI:3770811
ht3	Kit^tm1Alf/Kit^Mhdasow3	involves: 129S2/SvPas * C3HeB/FeJ	MGI:3771709
cx4	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh Kit^tm1Alf/Kit⁺	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316641
cx5	Mitf^tm7.1Arnh/Mitf^tm7.1Arnh Kit^tm1Alf/Kit⁺	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316642
cx6	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit⁺	involves: 129S2/SvPas * C57BL/6	MGI:3783653
cx7	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit^tm1Alf	involves: 129S2/SvPas * C57BL/6	MGI:3783651

Allelic Composition	Kit^tm1Alf/Kit^tm1Alf
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:36230 , J:103157 )

• newborns rapidly die after birth (J:36230)

hematopoietic system

anemia ( J:103157 )

• severe megaloblastic anemia

macrocytic anemia ( J:36230 )

• severe macrocytic and hyperchromic anemia

pigmentation

abnormal melanocyte morphology ( J:36230 )

• melanocytes are absent form the skin of newborns

reproductive system

abnormal female germ cell morphology ( J:36230 )

• no beta-gal positive cells are found in the ovaries of homozygote newborns, indicating that migration, proliferation, and/or survival of germ cells is impaired

abnormal primordial germ cell migration ( J:36230 )

• migration of primordial germ cells (PGC) cells at E9.5 is impaired, with PGCs found in the ventral half of the gut and sometimes grouped in clumps in ectopic sites such as inside of the vitelline artery, instead of being found in the gut wall

embryo

abnormal melanoblast migration ( J:36230 )

• from E11 onwards, melanoblasts are absent from the surface ectoderm of embryos, indicating that migration/survival of melanoblasts is impaired from E10.5 onwards

integument

pallor ( J:36230 )

• newborns are pale

cellular

abnormal female germ cell morphology ( J:36230 )

• no beta-gal positive cells are found in the ovaries of homozygote newborns, indicating that migration, proliferation, and/or survival of germ cells is impaired

abnormal melanoblast migration ( J:36230 )

• from E11 onwards, melanoblasts are absent from the surface ectoderm of embryos, indicating that migration/survival of melanoblasts is impaired from E10.5 onwards

abnormal primordial germ cell migration ( J:36230 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

reproductive system

abnormal oocyte morphology ( J:67923 )

• oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

• males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

• reduction in epididymal sperm counts

asthenozoospermia ( J:103157 )

• decrease in sperm motility

abnormal female reproductive system morphology ( J:67923 )

abnormal ovarian follicle number ( J:67923 )

• ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

• primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

• antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

abnormal male reproductive system morphology ( J:103157 )

decreased testis weight ( J:103157 )

• testes weights are 50% lower than in wild-type

• however, no difference in seminal vesicle weight

decreased epididymis weight ( J:103157 )

• epididymides weights are 25% lower than in wild-type before 30 days of age; at 30 days of age when no spermatozoa are present, weights do not differ

reduced male fertility ( J:103157 )

• in vivo and in vitro fertility is greatly reduced in males

• female fertility is normal

limbs/digits/tail

non-pigmented tail tip ( J:36230 )

• white tail tip

endocrine/exocrine glands

abnormal ovarian follicle number ( J:67923 )

• ovaries contain increased numbers of type 5a follicles and fewer numbers of type 5b (preantral follicles) follicles

decreased primordial ovarian follicle number ( J:67923 )

• primordial follicle numbers decrease with increasing age

abnormal ovarian folliculogenesis ( J:67923 )

• antrum formation in preantral follicles is disrupted at P20, as fewer preantral follicles with 3 or 4 layers of granulosa cells develop an antral cavity

decreased testis weight ( J:103157 )

• testes weights are 50% lower than in wild-type

• however, no difference in seminal vesicle weight

embryo

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

integument

white spotting ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip resulting in white feet and a white tail tip

non-pigmented tail tip ( J:36230 )

• white tail tip

cellular

abnormal oocyte morphology ( J:67923 )

• oocyte growth is altered

abnormal male germ cell morphology ( J:103157 )

• males exhibit a higher number of spermatozoa without acrosomal contents

oligozoospermia ( J:103157 )

• reduction in epididymal sperm counts

abnormal melanoblast migration ( J:36230 )

• melanoblasts fail to colonize the distal parts of the limb buds and the tail tip

asthenozoospermia ( J:103157 )

• decrease in sperm motility

Allelic Composition	Kit^tm1Alf/Kit^Mhdasow3
Genetic Background	involves: 129S2/SvPas * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^Mhdasow3 mutation (1 available); any Kit mutation (182 available)
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Germ cell phenotypes of Kit^Mhdasco1/Kit^Mhdasco1, Kit^Mhdasow3/Kit^Mhdasow3, Kit^Mhdasco5/Kit^Mhdasco5, Kit^tm1Alf/Kit^Mhdasow3 and Kit^Whc1/Kit^Whc1 mice

reproductive system

abnormal spermatogenesis ( J:125831 )

• mutants show no pattern of spermatogenesis

liver/biliary system

hepatic steatosis ( J:125831 )

Allelic Composition	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh Kit^tm1Alf/Kit⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)
Mitf^tm5.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:182722 )

belly spot ( J:182722 )

• slightly larger belly spots

abnormal melanocyte morphology ( J:182722 )

• more melanocytes around the eyes at E15.5 and at birth compared to controls involving Mitf^tm7.1Arnh

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

integument

abnormal coat/hair pigmentation ( J:182722 )

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

belly spot ( J:182722 )

• slightly larger belly spots

Allelic Composition	Mitf^tm7.1Arnh/Mitf^tm7.1Arnh Kit^tm1Alf/Kit⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)
Mitf^tm7.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:182722 )

• slightly larger belly spot

integument

belly spot ( J:182722 )

• slightly larger belly spot

Allelic Composition	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-2H mutation (2 available); any Adamts20 mutation (93 available)
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

integument

belted ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

white spotting ( J:133403 )

• mice exhibit a wider dorsal and ventral belt than in either Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to Adamts20^bt-2H homozygotes or Kit^tm1Alf heterozygotes

Allelic Composition	Adamts20^bt-2H/Adamts20^bt-2H Kit^tm1Alf/Kit^tm1Alf
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belted ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

white spotting ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

integument

belted ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

white spotting ( J:133403 )

• mice exhibit a synergistic increase in spotting resulting in a white belt compared to homozygotes of either individual allele

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