Phenotypes associated with this allele

• Allele Symbol: Dffb^tm1Osa
• Allele Name: targeted mutation 1, Shigekazu Nagata
• Allele ID: MGI:2449797
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dffb^tm1Osa/Dffb^tm1Osa	B6.129-Dffb^tm1Osa	MGI:6315920
hm2	Dffb^tm1Osa/Dffb^tm1Osa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3694081
cx3	Dffb^tm1Osa/Dffb^tm1Osa Dnase2a^tm1Osa/Dnase2a^tm1Osa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3694082

Genotype
MGI:6315920

hm1

• Allelic Composition: Dffb^tm1Osa/Dffb^tm1Osa
• Genetic Background: B6.129-Dffb^tm1Osa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased response of heart to induced stress ( J:259377 )

• the myocardial hypertrophic response is blocked in mice after 8 weeks of aortic banding, with the ratios of heart weight/body weight heart weight/tibia length, and lung weight/body weight decreased, improved cardiac dilation and reduced cardiac dysfunction, ran reduced cardiac fibrotic response compared to controls, indicating suppressed pressure overload-induced cardiac remodeling

• the number of apoptotic cells is decreased in myocardial tissue is decreased in mice subjected to aortic banding

homeostasis/metabolism

decreased response of heart to induced stress ( J:259377 )

• the myocardial hypertrophic response is blocked in mice after 8 weeks of aortic banding, with the ratios of heart weight/body weight heart weight/tibia length, and lung weight/body weight decreased, improved cardiac dilation and reduced cardiac dysfunction, ran reduced cardiac fibrotic response compared to controls, indicating suppressed pressure overload-induced cardiac remodeling

• the number of apoptotic cells is decreased in myocardial tissue is decreased in mice subjected to aortic banding

Genotype
MGI:3694081

hm2

• Allelic Composition: Dffb^tm1Osa/Dffb^tm1Osa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

cellular

abnormal apoptosis ( J:81474 )

• no fragmentation of DNA strands is seen in apoptotic thymocytes

• otherwise normal phenotype

Genotype
MGI:3694082

cx3

• Allelic Composition: Dffb^tm1Osa/Dffb^tm1Osa; Dnase2a^tm1Osa/Dnase2a^tm1Osa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

growth/size/body

decreased body size ( J:81474 )

• slightly smaller than controls

hematopoietic system

abnormal thymus morphology ( J:81474 )

• many large abnormal foci containing macrophage with intact DNA filaments

small thymus ( J:81474 )

thymus hypoplasia ( J:81474 )

• cellularity 12% of controls

abnormal T cell differentiation ( J:81474 )

• T cell development inhibited at an early progenitor stage

increased double-negative T cell number ( J:81474 )

decreased double-positive T cell number ( J:81474 )

• about 1/3 the level seen in controls

anemia ( J:81474 )

immune system

abnormal thymus morphology ( J:81474 )

• many large abnormal foci containing macrophage with intact DNA filaments

small thymus ( J:81474 )

thymus hypoplasia ( J:81474 )

• cellularity 12% of controls

abnormal T cell differentiation ( J:81474 )

• T cell development inhibited at an early progenitor stage

increased double-negative T cell number ( J:81474 )

decreased double-positive T cell number ( J:81474 )

• about 1/3 the level seen in controls

endocrine/exocrine glands

abnormal thymus morphology ( J:81474 )

• many large abnormal foci containing macrophage with intact DNA filaments

small thymus ( J:81474 )

thymus hypoplasia ( J:81474 )

• cellularity 12% of controls