Phenotypes associated with this allele

• Allele Symbol: Zar1^tm1Zuk
• Allele Name: targeted mutation 1, Martin M Matzuk
• Allele ID: MGI:2449829
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zar1^tm1Zuk/Zar1^tm1Zuk	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:2653497
hm2	Zar1^tm1Zuk/Zar1^tm1Zuk	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J	MGI:4414796

Genotype
MGI:2653497

hm1

• Allelic Composition: Zar1^tm1Zuk/Zar1^tm1Zuk
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

female infertility ( J:81447 )

♀ • ovarian development and oogenesis through fertilization were unimpaired, but embryos arrested at one-cell stage

♀ • maternal and paternal genomes remain separate in arrested zygotes

♀ • fewer than 20% of embryos progressed to two-cell stage

♀ • no embryos developed to 4-cell stage

cellular

maternal effect ( J:81447 )

• all embryos derived from homozygous dams fail to develop

Genotype
MGI:4414796

hm2

• Allelic Composition: Zar1^tm1Zuk/Zar1^tm1Zuk
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

reproductive system

female infertility ( J:81447 )

♀ • ovarian development and oogenesis through fertilization were unimpaired, but embryos arrested at one-cell stage

♀ • maternal and paternal genomes remain separate in arrested zygotes

♀ • fewer than 20% of embryos progressed to two-cell stage

♀ • no embryos developed to 4-cell stage

cellular

maternal effect ( J:81447 )

• all embryos derived from homozygous dams fail to develop