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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspg2tm1Soin
targeted mutation 1, Raija Soininen
MGI:2449915
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hspg2tm1Soin/Hspg2tm1Soin B6.129P2-Hspg2tm1Soin MGI:4880692
cx2
 		Col18a1tm1Hms/Col18a1tm1Hms
Hspg2tm1Soin/Hspg2tm1Soin 		involves: C57BL/6 * C57BL/6J MGI:3047564


Genotype
MGI:4880692
hm1
Allelic
Composition		 Hspg2tm1Soin/Hspg2tm1Soin
Genetic
Background		 B6.129P2-Hspg2tm1Soin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspg2tm1Soin mutation (1 available); any Hspg2 mutation (310 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:167008 )
N
• normal fasting plasma triglyceride and cholesterol levels




Genotype
MGI:3047564
cx2
Allelic
Composition		 Col18a1tm1Hms/Col18a1tm1Hms
Hspg2tm1Soin/Hspg2tm1Soin
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col18a1tm1Hms mutation (2 available); any Col18a1 mutation (139 available)
Hspg2tm1Soin mutation (1 available); any Hspg2 mutation (310 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens development ( J:81399 )
• double mutant newborns display accelerated lens degeneration relative to Hspg2tm1Soin mice, as well as more severe lens defects relative to single mutant mice
• the first signs of abnormal development are already apparent in neonates in that leakages of cells are detected in the anterior region of the lens; in Hspg2tm1Soin mice, leakages are observed in a more posterior region and are less severe
• in double mutant lenses, epithelial cells migrate focally outwards, proliferate and remain external for several weeks




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory