All Phenotypes Mitf<mi-vga9> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mitf^mi-vga9
transgenic insertion 9
MGI:2449916

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mitf^mi-vga9/Mitf^mi-vga9	involves: C57BL/6 * CBA	MGI:4455017
ht2	Mitf^mi-vga9/Mitf^tm1Arnh	involves: 129S1/Sv * C3H/He * C57BL/6	MGI:3774180
ht3	Mitf^tm7Arnh/Mitf^mi-vga9	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA	MGI:5316595
ht4	Mitf^tm5Arnh/Mitf^mi-vga9	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA	MGI:5316592
ht5	Mitf^tm4Arnh/Mitf^mi-vga9	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA	MGI:5316593
ht6	Mitf^tm6Arnh/Mitf^mi-vga9	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA	MGI:5316594
cx7	Mitf^mi-vga9/Mitf^mi-vga9 Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)	MGI:3044415
cx8	Mitf^mi-vga9/Mitf⁺ Pax6^Sey-Neu/Pax6⁺	involves: C57BL/6 * CBA	MGI:5316876
cx9	Mitf^mi-vga9/Mitf^mi-vga9 Pax6^Sey-Neu/Pax6^Sey-Neu	involves: C57BL/6 * CBA	MGI:5316877
cx10	Mitf^mi-vga9/Mitf^mi-vga9 Pax6^Sey-Neu/Pax6⁺	involves: C57BL/6 * CBA	MGI:5316878
cx11	Mitf^mi-vga9/Mitf^mi-vga9 Tg(PAX6)77Ndha/Tg(PAX6)77Ndha	involves: C57BL/6 * CBA	MGI:5316881

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

abnormal retina pigment epithelium morphology ( J:188155 )

• dorsal thickening of the retinal pigment epithelium observed at E13.5

vision/eye

abnormal retina pigment epithelium morphology ( J:188155 )

• dorsal thickening of the retinal pigment epithelium observed at E13.5

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^mi-vga9/Mitf^tm1Arnh
Genetic Background	involves: 129S1/Sv * C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Mitf^tm1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:130168 )

• mice have a white coat color rarely with some dark spots

vision/eye

vision/eye phenotype ( J:130168 )

N	• mice have normal size eyes unlike the small eyes in mice with homozygous null alleles of this gene

integument

absent coat pigmentation ( J:130168 )

• mice have a white coat color rarely with some dark spots

Allelic Composition	Mitf^tm7Arnh/Mitf^mi-vga9
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Mitf^tm7Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

irregular coat pigmentation ( J:182722 )

• intermediate coat color and spotting

integument

irregular coat pigmentation ( J:182722 )

• intermediate coat color and spotting

Allelic Composition	Mitf^tm5Arnh/Mitf^mi-vga9
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Mitf^tm5Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:182722 )

• very small white belly spots

integument

belly spot ( J:182722 )

• very small white belly spots

Allelic Composition	Mitf^tm4Arnh/Mitf^mi-vga9
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Mitf^tm4Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:182722 )

• mice are almost completely white

integument

absent coat pigmentation ( J:182722 )

• mice are almost completely white

Allelic Composition	Mitf^tm6Arnh/Mitf^mi-vga9
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Mitf^tm6Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

irregular coat pigmentation ( J:182722 )

• intermediate coat color and spotting

integument

irregular coat pigmentation ( J:182722 )

• intermediate coat color and spotting

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9 Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89821 )

• mice die within 3 weeks of birth

pigmentation

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^{mi-vga9/mi-vga9} mice

craniofacial

delayed tooth eruption ( J:89821 )

skeleton

delayed tooth eruption ( J:89821 )

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

osteopetrosis ( J:89821 )

• severe, with complete filling of the bone marrow cavity with bony material

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^{mi-vga9/mi-vga9} mice

hematopoietic system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

immune system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

integument

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^{mi-vga9/mi-vga9} mice

growth/size/body

delayed tooth eruption ( J:89821 )

Allelic Composition	Mitf^mi-vga9/Mitf⁺ Pax6^Sey-Neu/Pax6⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Pax6^Sey-Neu mutation (1 available); any Pax6 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina pigment epithelium morphology ( J:188155 )

• dorsal thickening observed at E13.5

pigmentation

abnormal retina pigment epithelium morphology ( J:188155 )

• dorsal thickening observed at E13.5

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9 Pax6^Sey-Neu/Pax6^Sey-Neu
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina pigment epithelium morphology ( J:188155 )

• massive enlargement of the retinal pigment epithelium at E13.5

pigmentation

abnormal retina pigment epithelium morphology ( J:188155 )

• massive enlargement of the retinal pigment epithelium at E13.5

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9 Pax6^Sey-Neu/Pax6⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina pigment epithelium morphology ( J:188155 )

• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth

pigmentation

abnormal retina pigment epithelium morphology ( J:188155 )

• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9 Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (74 available)
Tg(PAX6)77Ndha mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:188155 )

N	• no thickening of the retinal pigment epithelium

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