All Phenotypes Hcn2<tm1Ldw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn2^tm1Ldw/Hcn2^tm1Ldw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623023
cn2	Hcn2^tm1Ldw/Hcn2^tm2Ldw Myl7^tm1(cre)Krc/Myl7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3623024

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:81398 )

• 15.3g bodyweight at 8 weeks of age as opposed to 26.5g in controls

behavior/neurological

tremors ( J:81398 )

• whole body tremors

decreased locomotor activity ( J:81398 )

• less horizontal locomotor activity in open field tests

• less rearing

absence seizures ( J:81398 )

• frequent bilateral synchronous spike and wave discharges indicative of absence epilepsy

nervous system

absence seizures ( J:81398 )

• frequent bilateral synchronous spike and wave discharges indicative of absence epilepsy

abnormal nervous system electrophysiology ( J:81398 )

abnormal afterhyperpolarization ( J:81398 )

• in thalamocortical neurons

abnormal summary potential ( J:81398 )

• susceptibility to oscillatory activity in thalamocortical neurons

decreased channel response intensity ( J:81398 )

• thalamocortical relay neurons with dramatically reduced inward current

• inward current reduced about 1/3 in CA1 pyramidal cells

cardiovascular system

irregular heartbeat ( J:81398 )

• variable intervals between heart beats

abnormal sinoatrial node conduction ( J:81398 )

• sinus dysrhythmia at rest but not during spontaneous activity

• variable intervals between successive heart beats

• regular P wave in a normal PR interval indicating synoatrial node dysfunction

• 30% reduced inward current of sinoatrial cells

Allelic Composition	Hcn2^tm1Ldw/Hcn2^tm2Ldw Myl7^tm1(cre)Krc/Myl7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^tm1Ldw mutation (0 available); any Hcn2 mutation (31 available)
Hcn2^tm2Ldw mutation (0 available); any Hcn2 mutation (31 available)
Myl7^tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype