Phenotypes associated with this allele

• Allele Symbol: Commd10^{Tg(Vav1-icre)A2Kio}
• Allele Name: transgene insertion A2, Dimitris Kioussis
• Allele ID: MGI:2449949
• Summary: 76 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adh5^tm1.1Llli/Adh5^tm1.1Llli Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Adh5^tm1.1Llli Commd10^Tg(Vav1-icre)A2Kio	MGI:5049928
cn2	Ctps1^tm1c(KOMP)Wtsi/Ctps1^tm1c(KOMP)Wtsi Commd10^Tg(Vav1-icre)A2Kio/0	B6.Cg-Ctps1^tm1c(KOMP)Wtsi Commd10^Tg(Vav1-icre)A2Kio	MGI:7657888
cn3	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Egln1^tm2.1Fsl Commd10^Tg(Vav1-icre)A2Kio	MGI:5525143
cn4	Fbxo21^em1Smbk/Fbxo21^em1Smbk Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Fbxo21^em1Smbk Commd10^Tg(Vav1-icre)A2Kio	MGI:7444791
cn5	Ly6e^tm1c(EUCOMM)Hmgu/Ly6e^tm1c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Ly6e^tm1c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio	MGI:6449004
cn6	Patz1^tm1.2Welm/Patz1^tm1.2Welm Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Patz1^tm1.2Welm Commd10^Tg(Vav1-icre)A2Kio	MGI:5572830
cn7	Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Pkn3^tm1.1Mrl Commd10^Tg(Vav1-icre)A2Kio	MGI:5688866
cn8	Snai1^tm1.1Stjw/Snai1^tm1.1Stjw Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Snai1^tm1.1Stjw Commd10^Tg(Vav1-icre)A2Kio	MGI:5659610
cn9	Cdkn1a^tm1Led/Cdkn1a^tm1Led Zbtb17^tm1Cksn/Zbtb17^tm1Cksn Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Zbtb17^tm1Cksn Cdkn1a^tm1Led Commd10^Tg(Vav1-icre)A2Kio	MGI:5006710
cn10	Zbtb17^tm1Cksn/Zbtb17^tm1Cksn Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Zbtb17^tm1Cksn Commd10^Tg(Vav1-icre)A2Kio	MGI:5006709
cn11	Zfp318^tm1.1Jhws/Zfp318^tm1.1Jhws Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Zfp318^tm1.1Jhws Tg^Vav1-creA2Kio	MGI:5606282
cn12	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^Tg(Vav1-icre)A2Kio	MGI:5558063
cn13	Cd40lg^tm1Parl/Cd40lg^tm1Parl Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5585442
cn14	Cd40lg^tm1Parl/Y Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5585443
cn15	Jak2^tm1.1Ble/Jak2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:6356966
cn16	Commd10^Tg(Vav1-icre)A2Kio/0 Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:7448515
cn17	Plek2^tm1Pji/Plek2^tm1Pji Jak2^tm1.1Ble/Jak2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:6356967
cn18	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5525153
cn19	F8^tm1.1Rmnt/F8^tm1.1Rmnt Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL	MGI:5582833
cn20	Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5427982
cn21	Rbpj^tm1Hon/Rbpj^tm1Hon Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	MGI:4821304
cn22	Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	MGI:3804186
cn23	Ikzf1^tm1.1(Pax5)Mbu/Ikzf1^+ Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	MGI:3804204
cn24	Idh1^tm1Mak/Idh1^tm1Mak Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5438277
cn25	Myd88^tm1Defr/Myd88^tm1Defr Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3809645
cn26	Tcf3^tm1Mbu/Tcf3^tm1Mbu Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0 Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129P2/OlaHsd * C57BL * CBA	MGI:3804203
cn27	Syk^tm1.1Nns/Syk^tm1.1Nns Tg(Tie1-cre)9Ref/0 Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca	MGI:5314235
cn28	Bmi1^tm1Sgon/Bmi1^tm1Sgon Commd10^Tg(Vav1-icre)A2Kio/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca	MGI:5693398
cn29	Lmo4^tm1Slp/Lmo4^tm1Slp Yeats4^em1Zfa/Yeats4^em1Zfa Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca	MGI:6385529
cn30	Lmo4^tm1Slp/Lmo4^tm1Slp Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca	MGI:6385528
cn31	Bcor^tm1.1Vjba/Y Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S1/Sv * C57BL/6 * CBA/Ca	MGI:5925308
cn32	Trp53^tm1Tyj/Trp53^tm1Tyj Riok2^tm1c(KOMP)Wtsi/Riok2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712734
cn33	Rr7^tm3.1Kio/Rr7^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5305077
cn34	Kmt2a^tm1Brad/Kmt2a^tm1Brad Commd10^Tg(Vav1-icre)A2Kio/?	involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca	MGI:3849329
cn35	Adgrf5^tm1.1Bstc/Adgrf5^tm1.2Bstc Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca	MGI:5490534
cn36	Cdk5rap3^tm1c(EUCOMM)Hmgu/Cdk5rap3^tm1c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6295912
cn37	Il22^tm1.1Lex/Il22^tm1.1Lex Riok2^tm1c(KOMP)Wtsi/Riok2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712732
cn38	Jak2^tm1.2Ble/Jak2^+ Picalm^tm1.1Tmae/Picalm^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL	MGI:5640746
cn39	Jak2^tm1.2Ble/Jak2^+ Picalm^tm1.1Tmae/Picalm^tm1.1Tmae Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL	MGI:5640744
cn40	Picalm^tm1.1Tmae/Picalm^tm1.1Tmae Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL	MGI:5640745
cn41	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Rptor^tm1.1Dmsa/Rptor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S/SvEv * C57BL/10 * CBA/Ca	MGI:6513971
cn42	Sppl3^tm1Itl/Sppl3^tm1Itl Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca	MGI:6515779
cn43	Kmt5b^tm1Jnw/Kmt5b^tm1Jnw Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca	MGI:3810116
cn44	Kitl^tm2.1Sjm/Kitl^tm2.2Sjm Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: BALB/cJ * C57BL * CBA/Ca * SJL	MGI:5306351
cn45	Commd10^Tg(Vav1-icre)A2Kio/0 Map3k7^tm1.1Arte/Map3k7^tm1.1Arte	involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca	MGI:7451043
cn46	Cdh5^tm8Dvst/Cdh5^tm8Dvst Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/10 * CBA/Ca	MGI:5661695
cn47	Syk^tm1.1Nns/Syk^tm1.1Nns Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/10 * CBA/Ca	MGI:5314234
cn48	Piezo1^tm2.1Apat/Piezo1^tm2.1Apat Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA	MGI:5776602
cn49	Tg(Kit*D814V)3Roer/0 Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:4942368
cn50	Yeats4^em1Zfa/Yeats4^em1Zfa Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:6385521
cn51	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:6513967
cn52	Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:6303639
cn53	Satb1^tm2Kos/Satb1^tm2Kos Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:7281769
cn54	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:7311733
cn55	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5564914
cn56	Tg(JAK2*V617F)FF1Rsko/0 Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5553469
cn57	Gt(ROSA)26Sor^tm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5496264
cn58	Gt(ROSA)26Sor^tm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5496262
cn59	Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm Commd10^Tg(Vav1-icre)A2Kio/?	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5488604
cn60	Idh1^tm2Mak/Idh1^tm2Mak Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:5438280
cn61	Tg(Kit*D814V)1Roer/0 Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:4942367
cn62	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL	MGI:5301602
cn63	Chaf1b^tm2c(EUCOMM)Hmgu/Chaf1b^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6267349
cn64	Zbtb38^em1Dbhat/Zbtb38^em1Dbhat Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6696062
cn65	Brpf1^tm1c(EUCOMM)Wtsi/Brpf1^tm1c(EUCOMM)Wtsi Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	MGI:5902764
cn66	Chaf1b^tm2c(EUCOMM)Hmgu/Chaf1b^tm2c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6267348
cn67	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Riok2^tm1c(KOMP)Wtsi/Riok2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712737
cn68	Jagn1^tm1c(EUCOMM)Hmgu/Jagn1^tm1c(EUCOMM)Hmgu Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6N * C57BL/10 * CBA/Ca	MGI:5604905
cn69	Riok2^tm1c(KOMP)Wtsi/Riok2^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712638
cn70	Riok2^tm1c(KOMP)Wtsi/Riok2^tm1c(KOMP)Wtsi Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712637
cn71	Commd10^Tg(Vav1-icre)A2Kio/? Tnfrsf14^tm1.1Kro/Tnfrsf14^tm1.1Kro	involves: C57BL/6NCrl * C57BL/10 * CBA * SJL	MGI:5908557
cn72	Commd10^Tg(Vav1-icre)A2Kio/Commd10^+ Ociad1^tm1Msin/Ociad1^tm1Msin	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	MGI:6367554
cn73	Atg7^tm1Tchi/Atg7^tm1Tchi Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	MGI:5295638
cn74	Gt(ROSA)26Sor^tm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor^+ Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	MGI:5527435
cx75	Trp53^tm1Tyj/Trp53^tm1Tyj Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712735
cx76	Il22^tm1.1Lex/Il22^tm1.1Lex Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca	MGI:6712736

Genotype
MGI:5049928

cn1

• Allelic Composition: Adh5^tm1.1Llli/Adh5^tm1.1Llli; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Adh5^tm1.1Llli Commd10^{Tg(Vav1-icre)A2Kio}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:173666 )

N • mice exhibit normal survival following diethylnitrosamine (DEN) challenged

Genotype
MGI:7657888

cn2

• Allelic Composition: Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi}; Commd10^{Tg(Vav1-icre)A2Kio}/0
• Genetic Background: B6.Cg-Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}

mortality/aging

premature death ( J:348981 )

• mice do not survive after 6 weeks of age

prenatal lethality, incomplete penetrance ( J:348981 )

• fewer than the expected numbers of mice are obtained

endocrine/exocrine glands

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

growth/size/body

decreased body size ( J:348981 )

hematopoietic system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

anemia ( J:348981 )

• severe anemia

decreased bone marrow cell number ( J:348981 )

• bone marrow cellularity is reduced, with the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

• absolute numbers of erythroid and hematopoietic progenitors are reduced as bone marrow cellularity is reduced

• however, the percentage of LSK+ cells in bone marrow is normal

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

decreased hematopoietic stem cell number ( J:348981 )

• absolute numbers of hematopoietic progenitors are reduced as bone marrow cellularity is reduced

decreased megakaryocyte-erythroid progenitor cell number ( J:348981 )

• the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

immune system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

cellular

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

Genotype
MGI:5525143

cn3

• Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}

hematopoietic system

increased erythroid progenitor cell number ( J:202737 )

• increased numbers of BFU-E colonies are observed at both high and low concentrations of erythropoietin

polycythemia ( J:202737 )

• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

increased hematocrit ( J:202737 )

• hematocrits are modestly increased over controls

increased hemoglobin content ( J:202737 )

Genotype
MGI:7444791

cn4

• Allelic Composition: Fbxo21^em1Smbk/Fbxo21^em1Smbk; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Fbxo21^em1Smbk Commd10^{Tg(Vav1-icre)A2Kio}

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:333469 )

• in 5-FU-treated mice

hematopoietic system

abnormal stress erythropoiesis ( J:333469 )

• 5-FU-treated mice exhibit increased bone marrow failure and lethality compared with wild-type mice

increased granulocyte monocyte progenitor cell number ( J:333469 )

• in the bone marrow

increased T cell number ( J:333469 )

• in the bone marrow but not peripheral blood

decreased spleen weight ( J:333469 )

• slightly

abnormal bone marrow cell physiology ( J:333469 )

• slightly decreased CFY potential in vitro

• however, steady-state hematopoiesis and performance in competitive repopulation assay are normal

immune system

increased T cell number ( J:333469 )

• in the bone marrow but not peripheral blood

decreased spleen weight ( J:333469 )

• slightly

Genotype
MGI:6449004

cn5

• Allelic Composition: Ly6e^{tm1c(EUCOMM)Hmgu}/Ly6e^{tm1c(EUCOMM)Hmgu}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Ly6e^{tm1c(EUCOMM)Hmgu} Commd10^{Tg(Vav1-icre)A2Kio}

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:291868 )

• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

immune system

decreased neutrophil cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of neutrophils to the liver and spleen

decreased dendritic cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen

abnormal mononuclear cell morphology ( J:291868 )

♀ • by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver

decreased B cell number ( J:291868 )

• MHV-infected males and females show reduced hepatic and spleen B cell numbers

decreased NK cell number ( J:291868 )

• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen

decreased CD4-positive, alpha-beta T cell number ( J:291868 )

♀ • MHV-infected females show reduced hepatic CD4+ T cells

decreased macrophage cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of macrophages to the liver

decreased inflammatory response ( J:291868 )

♀ • at 3 days post MHV-infection, inflammation is moderately reduced in females compared to controls, but not in males

increased susceptibility to Coronaviridae infection ( J:291868 )

• mice are highly susceptible to mouse hepatitis virus-A59 (MHV) with mice infected with a high dose of MHV rapidly succumbing to infection by day 6

• males show greater susceptibility than females

• females and males infected with MHV show elevated spleen viral burden at both high and lower doses of MHV, however hepatic viral burden is similar in males and females

• viral burden and liver damage are elevated in females at a lower dose of MHV but not in males which exhibit saturated hepatic infection

• bone marrow-derived macrophages are more susceptible to MHV infection

• in splenocyte cultures, MHV infects macrophages, neutrophils, dendritic cells and B cells but not CD4+ or CD8+ T cells

• B cells from both male and female mice are highly susceptible to MHV infection

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:291868 )

• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

hematopoietic system

decreased neutrophil cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of neutrophils to the liver and spleen

decreased dendritic cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen

abnormal mononuclear cell morphology ( J:291868 )

♀ • by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver

decreased B cell number ( J:291868 )

• MHV-infected males and females show reduced hepatic and spleen B cell numbers

decreased NK cell number ( J:291868 )

• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen

decreased CD4-positive, alpha-beta T cell number ( J:291868 )

♀ • MHV-infected females show reduced hepatic CD4+ T cells

decreased macrophage cell number ( J:291868 )

♂ • MHV-infected males show reduced recruitment of macrophages to the liver

homeostasis/metabolism

increased circulating alanine transaminase level ( J:291868 )

♀ • females, but not males, infected with MHV exhibit increased serum alanine aminotransferase levels

liver/biliary system

abnormal liver morphology ( J:291868 )

♀ • females, but not males, infected with MHV exhibit higher levels of liver damage than controls

hepatic necrosis ( J:291868 )

♀ • by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males

pale liver ( J:291868 )

• mice infected with an intermediate viral dose of MHV exhibit liver pallor

Genotype
MGI:5572830

cn6

• Allelic Composition: Patz1^tm1.2Welm/Patz1^tm1.2Welm; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Patz1^tm1.2Welm Commd10^{Tg(Vav1-icre)A2Kio}

immune system

immune system phenotype ( J:209168 )

N • mice subjected to systemic anaphylaxis exhibit normal histamine release response of mast cells in vivo

N • mice exhibit normal cutaneous anaphylaxis response

N • bone marrow-derived mast cells exhibit normal early and late effector functions upon Fcer1-mediated activation

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

decreased interleukin-6 secretion ( J:209168 )

• in bone marrow-derived mast cells activated with TNP

cellular

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

hematopoietic system

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

Genotype
MGI:5688866

cn7

• Allelic Composition: Pkn3^tm1.1Mrl/Pkn3^tm1.1Mrl; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Pkn3^tm1.1Mrl Commd10^{Tg(Vav1-icre)A2Kio}

hematopoietic system

hematopoietic system phenotype ( J:216983 )

N • hematopoietic stem cell numbers are similar to controls at 6-8 weeks of age and cells perform similar to control cells in a competitive transplantation assay

Genotype
MGI:5659610

cn8

• Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Snai1^tm1.1Stjw Commd10^{Tg(Vav1-icre)A2Kio}

normal phenotype

no abnormal phenotype detected ( J:214991 )

• viable with no gross abnormalities at E14.5, E17.5 and P1

• hematopoietic progenitors from E9.5 embryos demonstrate comparable erythroid colony formation

Genotype
MGI:5006710

cn9

• Allelic Composition: Cdkn1a^tm1Led/Cdkn1a^tm1Led; Zbtb17^tm1Cksn/Zbtb17^tm1Cksn; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Zbtb17^tm1Cksn Cdkn1a^tm1Led Commd10^{Tg(Vav1-icre)A2Kio}

immune system

arrested T cell differentiation ( J:170508 )

• double negative to double positive differentiation is blocked unlike in wild-type mice

hematopoietic system

arrested T cell differentiation ( J:170508 )

• double negative to double positive differentiation is blocked unlike in wild-type mice

Genotype
MGI:5006709

cn10

• Allelic Composition: Zbtb17^tm1Cksn/Zbtb17^tm1Cksn; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Zbtb17^tm1Cksn Commd10^{Tg(Vav1-icre)A2Kio}

immune system

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

arrested T cell differentiation ( J:170508 )

• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice

• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro

decreased T cell number ( J:170508 )

• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells

decreased double-negative T cell number ( J:170508 )

decreased gamma-delta T cell number ( J:170508 )

• 7-fold

hematopoietic system

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

arrested T cell differentiation ( J:170508 )

• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice

• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro

decreased T cell number ( J:170508 )

• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells

decreased double-negative T cell number ( J:170508 )

decreased gamma-delta T cell number ( J:170508 )

• 7-fold

cellular

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

endocrine/exocrine glands

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells

Genotype
MGI:5606282

cn11

• Allelic Composition: Zfp318^tm1.1Jhws/Zfp318^tm1.1Jhws; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Zfp318^tm1.1Jhws Tg^Vav1-creA2Kio

immune system

decreased transitional stage T2 B cell number ( J:215815 )

• slight decrease in splenic T2 B cells in 4 week old mice

decreased IgD level ( J:215815 )

• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations

increased IgM level ( J:215815 )

• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations

hematopoietic system

decreased transitional stage T2 B cell number ( J:215815 )

• slight decrease in splenic T2 B cells in 4 week old mice

decreased IgD level ( J:215815 )

• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations

increased IgM level ( J:215815 )

• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations

Genotype
MGI:5558063

cn12

• Allelic Composition: Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality and spleen and liver bacterial counts compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

Genotype
MGI:5585442

cn13

• Allelic Composition: Cd40lg^tm1Parl/Cd40lg^tm1Parl; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:213459 )

♀N • mice exhibit normal hemograms

thrombocytopenia ( J:213459 )

♀ • decreased circulating platelets 2 min after administration of agonists

increased IgG1 level ( J:213459 )

♀

decreased IgM level ( J:213459 )

♀

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:213459 )

♀N • mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system

increased IgG1 level ( J:213459 )

♀

decreased IgM level ( J:213459 )

♀

Genotype
MGI:5585443

cn14

• Allelic Composition: Cd40lg^tm1Parl/Y; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:213459 )

♂N • mice exhibit normal hemograms

thrombocytopenia ( J:213459 )

♂ • decreased circulating platelets 2 min after administration of agonists

increased IgG1 level ( J:213459 )

♂

decreased IgM level ( J:213459 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:213459 )

♂N • mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system

increased IgG1 level ( J:213459 )

♂

decreased IgM level ( J:213459 )

♂

Genotype
MGI:6356966

cn15

• Allelic Composition: Jak2^tm1.1Ble/Jak2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

premature death ( J:257910 )

• all mice die around 30 weeks of age

• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show reversion of lethality

hematopoietic system

enlarged spleen ( J:257910 )

extramedullary hematopoiesis ( J:257910 )

• mice exhibit extramedullary hematopoiesis

• however, mice do not develop myelofibrosis

increased megakaryocyte cell number ( J:257910 )

increased erythroid progenitor cell number ( J:257910 )

• bone marrow stem cell populations show an expansion of the erythroid progenitor population within myeloid progenitor cell

• however, long-term and short-term hematopoietic stem cells and multipotent progenitor compositions are not affected

increased megakaryocyte progenitor cell number ( J:257910 )

• bone marrow stem cell populations show an expansion of the megakaryocytic progenitor population within myeloid progenitor cells

abnormal erythrocyte morphology ( J:257910 )

• red blood cell mass is roughly tripled by increasing the absolute whole-body red blood cell number

increased erythrocyte cell number ( J:257910 )

• erythrocytosis

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of erythroid cells

thrombocytosis ( J:257910 )

increased leukocyte cell number ( J:257910 )

• leukocytosis, including neutrophilia

increased granulocyte number ( J:257910 )

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells

increased neutrophil cell number ( J:257910 )

reticulocytosis ( J:257910 )

homeostasis/metabolism

abnormal blood coagulation ( J:257910 )

• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney

abnormal thrombosis ( J:257910 )

• moribund mice often show symptoms of thrombosis, including low extremity paralysis and coolness, tachycardia, and tachypnea

abnormal cytokine level ( J:257910 )

• increase in several proinflammatory cytokines, including CCL3 and CSF1

immune system

enlarged spleen ( J:257910 )

increased leukocyte cell number ( J:257910 )

• leukocytosis, including neutrophilia

increased granulocyte number ( J:257910 )

• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells

increased neutrophil cell number ( J:257910 )

abnormal cytokine level ( J:257910 )

• increase in several proinflammatory cytokines, including CCL3 and CSF1

behavior/neurological

limb paralysis ( J:257910 )

• low extremity paralysis in moribund mice

cardiovascular system

abnormal blood vessel morphology ( J:257910 )

• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney

• mice treated with repeated injections of Ly-6G antibody to reduce the peripheral neutrophil count do not show alternations in vascular occlusions

• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show a reduction in vascular occlusion formation

increased heart rate ( J:257910 )

• tachycardia in moribund mice

respiratory system

tachypnea ( J:257910 )

• tachypnea in moribund mice

growth/size/body

enlarged spleen ( J:257910 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myeloproliferative neoplasm		DOID:2226		J:257910

Genotype
MGI:7448515

cn16

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/0; Nfil3^tm1.2Kubo/Nfil3^tm1.2Kubo
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

decreased dendritic cell number ( J:334296 )

• cDC1s virtually absent

immune system

decreased dendritic cell number ( J:334296 )

• cDC1s virtually absent

Genotype
MGI:6356967

cn17

• Allelic Composition: Plek2^tm1Pji/Plek2^tm1Pji; Jak2^tm1.1Ble/Jak2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

premature death ( J:257910 )

• more than 80% of mice survive beyond 40 weeks

• mice treated with phenylhydrazine to further reduce red blood counts show an even greater improvement in survival

hematopoietic system

hematopoietic system phenotype ( J:257910 )

N • mice exhibit amelioration of the neutrophilia and thrombocytosis, partial reversion of reticulocytosis, mild reduction in red blood cell counts, fewer megakaryocytes and megakaryocyte clusters, reduced spleen size, and reversion of about 25% of the red blood cell expansion seen in single Jak2^tm1.1Ble conditional mutants

N • bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show a reduction in the increased proliferation of erythroid and granulocytic cells seen in single Jak2^tm1.1Ble conditional mutants

abnormal granulocyte differentiation ( J:257910 )

• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells

abnormal megakaryocyte differentiation ( J:257910 )

• early-stage megakaryocytic differentiation to CD41+ cells is mildly decreased in cultured cells

extramedullary hematopoiesis ( J:257910 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:257910 )

N • mice show decreased vascular occlusions than in single Jak2^tm1.1Ble conditional mutants, with a decrease in the number of large clots with compact red blood cells and improved blood flow

immune system

immune system phenotype ( J:257910 )

N • several proinflammatory cytokines, including CCL3 and CSF1, that are increased in single Jak2^tm1.1Ble conditional mutants are reduced

abnormal granulocyte differentiation ( J:257910 )

• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells

cellular

abnormal cell differentiation ( J:257910 )

• erythroid differentiation to Ter119/CD71 double-positive cells is mildly decreased in cultured cells

abnormal granulocyte differentiation ( J:257910 )

• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells

abnormal megakaryocyte differentiation ( J:257910 )

• early-stage megakaryocytic differentiation to CD41+ cells is mildly decreased in cultured cells

Genotype
MGI:5525153

cn18

• Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

abnormal definitive hematopoiesis ( J:201572 )

• hematopoietic stem and progenitor cell populations are distorted

decreased common myeloid progenitor cell number ( J:201572 )

• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)

decreased bone marrow cell number ( J:201572 )

• found in femur and tibia of 5 day old mice as compared to control

decreased erythrocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

thrombocytopenia ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased hematopoietic stem cell number ( J:201572 )

• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)

immune system

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

growth/size/body

decreased body size ( J:201572 )

• newborn pups are smaller than controls

mortality/aging

postnatal lethality, incomplete penetrance ( J:201572 )

• lethality is a result severe anemia

• most mice die by day 10

Genotype
MGI:5582833

cn19

• Allelic Composition: F8^tm1.1Rmnt/F8^tm1.1Rmnt; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL

homeostasis/metabolism

decreased circulating factor VIII level ( J:212401 )

Genotype
MGI:5427982

cn20

• Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

thymus hypoplasia ( J:185179 )

• without affecting architecture

enlarged spleen ( J:185179 )

• in adult mice

abnormal erythropoiesis ( J:185179 )

• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.B and Ery.C in the bone marrow compared with control mice

• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.C in the spleen compared with control mice

• early erythropoiesis is partially blocked in association with a cell cycle defect

• proerythroblast exhibit reduced proliferation compared with control cells

• however, proerythroblast apoptosis rates are normal

anemia ( J:185179 )

• intrinsic as determined by bone marrow transplantation

hemolytic anemia ( J:185179 )

decreased granulocyte monocyte progenitor cell number ( J:185179 )

• decrease in the granulocyte macrophage progenitor (GMP) cells in the bone marrow

abnormal proerythroblast morphology ( J:185179 )

• ProE cells are increased 3.6- and 74-fold in the bone marrow and spleen compared with control mice

decreased erythroblast number ( J:185179 )

• in the bone marrow

increased erythroblast number ( J:185179 )

• 4.7-fold in the spleen

decreased erythrocyte cell number ( J:185179 )

decreased hemoglobin content ( J:185179 )

increased mean corpuscular volume ( J:185179 )

spherocytosis ( J:185179 )

reticulocytosis ( J:185179 )

• secondary

increased hematopoietic stem cell number ( J:185179 )

• early long and short term hematopoietic stem cells are increased compared to in control mice

• however, the number of lymphoid-primed multipotent progenitors is normal and the increased in hematopoietic stem cells disappears in the alter stages of differentiation

increased megakaryocyte-erythroid progenitor cell number ( J:185179 )

• increase in the megakaryocyte-erythroid progenitor (MEP) cells in the spleen

intermingled spleen red and white pulp ( J:185179 )

abnormal erythrocyte physiology ( J:185179 )

• reduced half-life

liver/biliary system

enlarged liver ( J:185179 )

• in adult mice

pale liver ( J:185179 )

renal/urinary system

pale kidney ( J:185179 )

cellular

abnormal cell cycle ( J:185179 )

• proerythroblast exhibit reduced proliferation compared with control cells

integument

pallor ( J:185179 )

• at birth

immune system

thymus hypoplasia ( J:185179 )

• without affecting architecture

enlarged spleen ( J:185179 )

• in adult mice

intermingled spleen red and white pulp ( J:185179 )

endocrine/exocrine glands

thymus hypoplasia ( J:185179 )

• without affecting architecture

growth/size/body

enlarged liver ( J:185179 )

• in adult mice

enlarged spleen ( J:185179 )

• in adult mice

Genotype
MGI:4821304

cn21

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

neoplasm

decreased tumor growth/size ( J:162770 )

• transplanted bone marrow progenitors transfected with BCR-ABL and NUP98-HOXA9 proliferate slower than similarly treated wild-type cells improving host survival

Genotype
MGI:3804186

cn22

• Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1Mbu; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

hematopoietic system

decreased pro-B cell number ( J:137719 )

• mice lack committed c-Kit+CD19+ pro-B cells

immune system

decreased pro-B cell number ( J:137719 )

• mice lack committed c-Kit+CD19+ pro-B cells

Genotype
MGI:3804204

cn23

• Allelic Composition: Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺; Tcf3^tm1Mbu/Tcf3^tm1Mbu; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:137719 )

N • development of pro-B cells is rescued

abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )

• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice

• Vk-Jk recombination of the Igk locus is absent

hematopoietic system

abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )

• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice

• Vk-Jk recombination of the Igk locus is absent

Genotype
MGI:5438277

cn24

• Allelic Composition: Idh1^tm1Mak/Idh1^tm1Mak; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:186700 )

N • mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers

abnormal common myeloid progenitor cell morphology ( J:186700 )

• increase in common lymphocyte progenitor cells in the bone marrow and spleen

abnormal common lymphocyte progenitor cell morphology ( J:186700 )

• increase in megakaryocyte-erythroid progenitors in the spleen

increased hematopoietic stem cell number ( J:186700 )

• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen

• increase in LK in the spleen

Genotype
MGI:3809645

cn25

• Allelic Composition: Myd88^tm1Defr/Myd88^tm1Defr; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

immune system

abnormal NK cell physiology ( J:139001 )

• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists

• NK cells in vivo have a blunted IFN-gamma response to LPS injections

hematopoietic system

abnormal NK cell physiology ( J:139001 )

• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists

• NK cells in vivo have a blunted IFN-gamma response to LPS injections

Genotype
MGI:3804203

cn26

• Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1Mbu; Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL * CBA

immune system

immune system phenotype ( J:137719 )

N • c-Kit+B220+ pro-B cells and c-Kit-B220+ developmental stages are rescued

Genotype
MGI:5314235

cn27

• Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns; Tg(Tie1-cre)9Ref/0; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

mortality/aging

mortality/aging ( J:181715 )

N • unlike null homozygotes, mice survive to adulthood

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• at E14.5, mice exhibit blood-filled vessels unlike wild-type mice

Genotype
MGI:5693398

cn28

• Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon; Commd10^{Tg(Vav1-icre)A2Kio}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

mortality/aging

premature death ( J:221849 )

• born at the expected frequency and fertile

• 93% die by 24-26 weeks

hematopoietic system

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation

abnormal hemopoiesis ( J:221849 )

decreased common myeloid progenitor cell number ( J:221849 )

• absolute numbers of progenitors reduced 2 fold

• reduced myeloid colony formation

abnormal erythropoiesis ( J:221849 )

• reduced erythroid colony formation

decreased bone marrow cell number ( J:221849 )

• cellularity reduced

• hypoplasia in femora

increased common lymphocyte progenitor cell number ( J:221849 )

• significant and progressive increase of immunophenotypic common lymphoid fraction

• lymphoid colony frequency is reduced 4X

• increased proportion of cells in S/G2/M phase

• homing of cells to host bone marrow is reduced

decreased B cell number ( J:221849 )

• significant loss of B lymphocytes in young mice

decreased T cell number ( J:221849 )

• significant loss of T lymphocytes in young mice

decreased myeloid cell number ( J:221849 )

• slight decrease in myeloid cells

decreased hematopoietic stem cell number ( J:221849 )

• in bone marrow

• remaining cells unable to repopulate irradiated hosts

• stem cells fail to maintain quiescence

abnormal spleen morphology ( J:221849 )

decreased spleen red pulp amount ( J:221849 )

• hypoplasia

small spleen ( J:221849 )

• 4X smaller than controls in older mice

abnormal spleen white pulp morphology ( J:221849 )

absent spleen germinal center ( J:221849 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:221849 )

• reduced size

decreased spleen white pulp amount ( J:221849 )

• hypoplasia

immune system

abnormal immune system cell morphology ( J:221849 )

decreased B cell number ( J:221849 )

• significant loss of B lymphocytes in young mice

decreased T cell number ( J:221849 )

• significant loss of T lymphocytes in young mice

abnormal immune system organ morphology ( J:221849 )

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation

abnormal spleen morphology ( J:221849 )

decreased spleen red pulp amount ( J:221849 )

• hypoplasia

small spleen ( J:221849 )

• 4X smaller than controls in older mice

abnormal spleen white pulp morphology ( J:221849 )

absent spleen germinal center ( J:221849 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:221849 )

• reduced size

decreased spleen white pulp amount ( J:221849 )

• hypoplasia

endocrine/exocrine glands

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation

Genotype
MGI:6385529

cn29

• Allelic Composition: Lmo4^tm1Slp/Lmo4^tm1Slp; Yeats4^em1Zfa/Yeats4^em1Zfa; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

abnormal lymphopoiesis ( J:282740 )

• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is impaired

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system

abnormal lymphopoiesis ( J:282740 )

• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is impaired

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

abnormal acute inflammation ( J:282740 )

• leukocyte infiltration is attenuated in the lungs after papain challenge

increased susceptibility to bacterial infection ( J:282740 )

• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls

• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection

Genotype
MGI:6385528

cn30

• Allelic Composition: Lmo4^tm1Slp/Lmo4^tm1Slp; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

abnormal lymphopoiesis ( J:282740 )

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, normal frequencies of alpha4Beta7+ CLPs are seen

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system

abnormal lymphopoiesis ( J:282740 )

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, normal frequencies of alpha4Beta7+ CLPs are seen

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

abnormal gut-associated lymphoid tissue morphology ( J:282740 )

• number of intestinal lymphoid follicles is decreased

• however, NK cells in the spleen and blood are not affected

decreased Peyer's patch number ( J:282740 )

• number of Peyers patches is decreased

abnormal acute inflammation ( J:282740 )

• leukocyte infiltration is attenuated in the lungs after papain challenge

increased susceptibility to bacterial infection ( J:282740 )

• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls

• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection

Genotype
MGI:5925308

cn31

• Allelic Composition: Bcor^tm1.1Vjba/Y; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA/Ca

hematopoietic system

increased neutrophil cell number ( J:231455 )

♂ • increase in peripheral blood neutrophil levels

♂ • however, no changes in red blood cell, platelet or lymphocyte levels

immune system

increased neutrophil cell number ( J:231455 )

♂ • increase in peripheral blood neutrophil levels

♂ • however, no changes in red blood cell, platelet or lymphocyte levels

Genotype
MGI:6712734

cn32

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj; Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:305794 )

N • the increase in IL-22 secretion seen in in vitro polarized TH22 cells in single conditional Riok2 heterozygotes is blunted

Genotype
MGI:5305077

cn33

• Allelic Composition: Rr7^tm3.1Kio/Rr7⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:179326 )

N • mice exhibit normal expression of Cd8a and Cd8b

Genotype
MGI:3849329

cn34

• Allelic Composition: Kmt2a^tm1Brad/Kmt2a^tm1Brad; Commd10^{Tg(Vav1-icre)A2Kio}/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

decreased common myeloid progenitor cell number ( J:149811 )

• there is about a 2-fold reduction in myeloid CFU number isolated from E13.5 fetal livers

• a similar reduction in CFU is observed with bone marrow cells

decreased pre-B cell number ( J:149811 )

• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow

abnormal bone marrow cell physiology ( J:149811 )

• mutant HSC bone marrow cells give less then a 1% long-term reconstitution when transplanted at a 1:1 ratio with wild-type bone marrow into irradiated mice

• mutant HSC bone marrow cells give only a 2% long-term reconstitution when transplanted at a 10:1 ratio

• poor reconstitution is observable as little as 4 weeks after transfer

immune system

decreased pre-B cell number ( J:149811 )

• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow

Genotype
MGI:5490534

cn35

• Allelic Composition: Adgrf5^tm1.1Bstc/Adgrf5^tm1.2Bstc; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca

respiratory system

respiratory system phenotype ( J:196943 )

N • mice exhibit normal surfactant homeostasis in the lung

Genotype
MGI:6295912

cn36

• Allelic Composition: Cdk5rap3^{tm1c(EUCOMM)Hmgu}/Cdk5rap3^{tm1c(EUCOMM)Hmgu}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca

mortality/aging

mortality/aging ( J:272566 )

N • mice survive to adulthood

hematopoietic system

abnormal hemopoiesis ( J:272566 )

• mild

Genotype
MGI:6712732

cn37

• Allelic Composition: Il22^tm1.1Lex/Il22^tm1.1Lex; Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca

hematopoietic system

increased erythroid progenitor cell number ( J:305794 )

• mice show an increase in RII and RIV erythroid precursors compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine

increased erythrocyte cell number ( J:305794 )

• mice exhibit increased numbers of peripheral blood red blood cells compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show alleviation of the stress-induced (via phenylhydrazine treatment) anemia seen in IL-22-sufficient Riok2-haploinsufficent mice

Genotype
MGI:5640746

cn38

• Allelic Composition: Jak2^tm1.2Ble/Jak2⁺; Picalm^tm1.1Tmae/Picalm⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

hematopoietic system

increased erythrocyte cell number ( J:220728 )

• increased red blood cell counts

increased hematocrit ( J:220728 )

• high hematocrit

increased hemoglobin content ( J:220728 )

decreased mean corpuscular hemoglobin ( J:220728 )

decreased mean corpuscular volume ( J:220728 )

thrombocytosis ( J:220728 )

• mild thrombocytosis

reticulocytosis ( J:220728 )

• elevated reticulocyte counts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycythemia vera		DOID:8997	OMIM:263300	J:220728

Genotype
MGI:5640744

cn39

• Allelic Composition: Jak2^tm1.2Ble/Jak2⁺; Picalm^tm1.1Tmae/Picalm^tm1.1Tmae; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

hematopoietic system

hypochromic microcytic anemia ( J:220728 )

decreased erythrocyte cell number ( J:220728 )

• decreased numbers of mature erythrocytes

decreased hematocrit ( J:220728 )

decreased hemoglobin content ( J:220728 )

decreased mean corpuscular hemoglobin ( J:220728 )

decreased mean corpuscular volume ( J:220728 )

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells

reticulocytosis ( J:220728 )

• elevated reticulocyte counts

homeostasis/metabolism

abnormal iron homeostasis ( J:220728 )

• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells

Genotype
MGI:5640745

cn40

• Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

hematopoietic system

microcytic anemia ( J:220728 )

decreased erythrocyte cell number ( J:220728 )

• decreased numbers of mature erythrocytes

decreased mean corpuscular hemoglobin ( J:220728 )

decreased mean corpuscular volume ( J:220728 )

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells

reticulocytosis ( J:220728 )

• elevated reticulocyte counts

homeostasis/metabolism

increased circulating erythropoietin level ( J:220728 )

• high levels of serum erythropoietin

abnormal iron homeostasis ( J:220728 )

• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells

Genotype
MGI:6513971

cn41

• Allelic Composition: Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur; Rptor^tm1.1Dmsa/Rptor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S/SvEv * C57BL/10 * CBA/Ca

immune system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

hematopoietic system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

Genotype
MGI:6515779

cn42

• Allelic Composition: Sppl3^tm1Itl/Sppl3^tm1Itl; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

mortality/aging ( J:280182 )

N • mice are born at normal Mendelian ratios and appear healthy

immune system

immune system phenotype ( J:280182 )

N • mice have normal numbers of T (CD3+CD4+, CD3+CD8+) and B cells (CD19+B220+) in spleen

abnormal NK cell differentiation ( J:280182 )

• mice show reduced expression of several NK cell surface receptors and a severe defect in NK cell maturation, with a 3-fold loss of CD27+CD11b+ in spleen and a 2-fold loss of CD27+CD11b+ in the bone marrow, indicating a partial block in maturation at the CD27+CD11b- stage

increased immature NK cell number ( J:280182 )

• mice show a 2-fold increase in the total number of immature CD27+CD11b- NK cells in the spleen and bone marrow

decreased NK cell number ( J:280182 )

• mice exhibit reduced numbers of peripheral NK cells; the number of NK cells (Lin-CD122+DX5+) is decreased ~2-fold in spleen and 3-fold in liver

• however, NK cell number is normal in the bone marrow

decreased mature NK cell number ( J:280182 )

• mice show a 2.6-fold decrease in the most mature CD27-CD11b+ NK cells in bone marrow, and a 4.9-fold reduction of CD27-CD11b+ cells in spleen

impaired natural killer cell mediated cytotoxicity ( J:280182 )

• mice exhibit reduced clearance of MHC class I-deficient tumors in vivo; 48 h after i.p. injection, recovery of RMA/s tumor cells is 7% versus 1% in control mice

• in an in vitro YAC-1 target lysis assay, splenic NK cells (DX5+) show ~60% of the cytotoxic activity seen in control mice across a range of E:T ratios

hematopoietic system

hematopoietic system phenotype ( J:280182 )

N • mice have normal numbers of T (CD3+CD4+, CD3+CD8+) and B cells (CD19+B220+) in spleen

abnormal NK cell differentiation ( J:280182 )

• mice show reduced expression of several NK cell surface receptors and a severe defect in NK cell maturation, with a 3-fold loss of CD27+CD11b+ in spleen and a 2-fold loss of CD27+CD11b+ in the bone marrow, indicating a partial block in maturation at the CD27+CD11b- stage

increased immature NK cell number ( J:280182 )

• mice show a 2-fold increase in the total number of immature CD27+CD11b- NK cells in the spleen and bone marrow

decreased NK cell number ( J:280182 )

• mice exhibit reduced numbers of peripheral NK cells; the number of NK cells (Lin-CD122+DX5+) is decreased ~2-fold in spleen and 3-fold in liver

• however, NK cell number is normal in the bone marrow

decreased mature NK cell number ( J:280182 )

• mice show a 2.6-fold decrease in the most mature CD27-CD11b+ NK cells in bone marrow, and a 4.9-fold reduction of CD27-CD11b+ cells in spleen

impaired natural killer cell mediated cytotoxicity ( J:280182 )

• mice exhibit reduced clearance of MHC class I-deficient tumors in vivo; 48 h after i.p. injection, recovery of RMA/s tumor cells is 7% versus 1% in control mice

• in an in vitro YAC-1 target lysis assay, splenic NK cells (DX5+) show ~60% of the cytotoxic activity seen in control mice across a range of E:T ratios

Genotype
MGI:3810116

cn43

• Allelic Composition: Kmt5b^tm1Jnw/Kmt5b^tm1Jnw; Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:139510 )

N • V(D)J recombination in B and T cells is normal

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

hematopoietic system

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

Genotype
MGI:5306351

cn44

• Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.2Sjm; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: BALB/cJ * C57BL * CBA/Ca * SJL

hematopoietic system

hematopoietic system phenotype ( J:180431 )

N • exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity

decreased hematopoietic cell number ( J:180431 )

• 2-fold as in Kitl^tm2.2Sjm heterozygotes in the bone marrow

Genotype
MGI:7451043

cn45

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/0; Map3k7^tm1.1Arte/Map3k7^tm1.1Arte
• Genetic Background: involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca

immune system

enlarged spleen ( J:332172 )

increased neutrophil cell number ( J:332172 )

• more splenic neutrophils

increased lymphocyte cell number ( J:332172 )

• more B cells

• normal number of T cells

increased B cell number ( J:332172 )

• more splenic B cells

decreased macrophage cell number ( J:332172 )

• in bone marrow

increased splenocyte number ( J:332172 )

enlarged axillary lymph nodes ( J:332172 )

enlarged inguinal lymph nodes ( J:332172 )

decreased interleukin-10 secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS

decreased interleukin-12b secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

decreased interleukin-6 secretion ( J:332172 )

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

• by BMDMs after 8h stimulation with Pam3CSK4 or R848

• by BMDMs after 4h stimulation with LPS

• normal by BMDMs after 8h stimulation with LPS

decreased tumor necrosis factor secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4 or R848

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

• by BMDMs after 4h stimulation with LPS

• normal by BMDMs after 8h stimulation with LPS

hematopoietic system

enlarged spleen ( J:332172 )

increased neutrophil cell number ( J:332172 )

• more splenic neutrophils

increased lymphocyte cell number ( J:332172 )

• more B cells

• normal number of T cells

increased B cell number ( J:332172 )

• more splenic B cells

decreased macrophage cell number ( J:332172 )

• in bone marrow

increased splenocyte number ( J:332172 )

growth/size/body

enlarged spleen ( J:332172 )

Genotype
MGI:5661695

cn46

• Allelic Composition: Cdh5^tm8Dvst/Cdh5^tm8Dvst; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/10 * CBA/Ca

liver/biliary system

liver/biliary system phenotype ( J:213676 )

N • mice are viable and fertile and show no significant differences in fetal liver weight and cellularity at E13.5 relative to controls, indicating normal hematopoietic colonization of the fetal liver

Genotype
MGI:5314234

cn47

• Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/10 * CBA/Ca

mortality/aging

mortality/aging ( J:181715 )

N • unlike null homozygotes, mice survive to adulthood

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• at E14.5, mice exhibit blood-filled vessels unlike control mice

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

cardiovascular system

abnormal blood vessel morphology ( J:181715 )

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

homeostasis/metabolism

edema ( J:181715 )

• at E14.5

Genotype
MGI:5776602

cn48

• Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

hematopoietic system

decreased erythrocyte cell number ( J:229436 )

decreased hematocrit ( J:229436 )

increased mean corpuscular hemoglobin ( J:229436 )

decreased mean corpuscular hemoglobin concentration ( J:229436 )

increased mean corpuscular volume ( J:229436 )

increased red blood cell distribution width ( J:229436 )

macrocytosis ( J:229436 )

abnormal spleen morphology ( J:229436 )

• spleens appear dark and redder than controls

abnormal splenic cell ratio ( J:229436 )

• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells

abnormal erythrocyte ion transport ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

increased erythrocyte osmotic fragility ( J:229436 )

• red blood cells exhibit increased osmotic fragility

homeostasis/metabolism

abnormal erythrocyte ion transport ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

decreased blood osmolality ( J:229436 )

• red blood cells are overhydrated, however, discoid morphology is normal

decreased circulating haptoglobin level ( J:229436 )

• decreased plasma haptoglobin concentration

abnormal calcium ion homeostasis ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

immune system

abnormal spleen morphology ( J:229436 )

• spleens appear dark and redder than controls

abnormal splenic cell ratio ( J:229436 )

• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells

Genotype
MGI:4942368

cn49

• Allelic Composition: Tg(Kit*D814V)3Roer/0; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

neonatal lethality ( J:169611 )

• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)3Roer

Genotype
MGI:6385521

cn50

• Allelic Composition: Yeats4^em1Zfa/Yeats4^em1Zfa; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

abnormal lymphopoiesis ( J:282740 )

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal

decreased lymphocyte cell number ( J:282740 )

• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver

• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs

• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria

• numbers of all innate lymphoid cell lineages are reduced

• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells

abnormal lymphocyte physiology ( J:282740 )

• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium

• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain

• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice

immune system

abnormal lymphopoiesis ( J:282740 )

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal

decreased lymphocyte cell number ( J:282740 )

• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver

• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs

• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria

• numbers of all innate lymphoid cell lineages are reduced

• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells

abnormal lymphocyte physiology ( J:282740 )

• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium

• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain

• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice

abnormal gut-associated lymphoid tissue morphology ( J:282740 )

• numbers of intestinal lymphoid follicles are reduced

decreased Peyer's patch number ( J:282740 )

• numbers of Peyers patches are reduced

decreased interferon-gamma secretion ( J:282740 )

• group 1 innate lymphoid cells show impaired production of IFN-gamma in response to Salmonella typhimurium infection

abnormal interleukin secretion ( J:282740 )

• IL-22 secreted by ILC3s in lamina propria lymphocytes is reduced in Citrobacter rodentium infected mice

decreased interleukin-12 secretion ( J:282740 )

• concentration of IL-12 in bronchoalveolar lavage fluid is reduced when mice are administered papain

decreased interleukin-5 secretion ( J:282740 )

• concentration of IL-5 in bronchoalveolar lavage fluid is reduced when mice are administered papain

abnormal acute inflammation ( J:282740 )

• leukocyte infiltration is reduced in lungs upon treatment with papain

• eosinophil infiltration in bronchoalveolar lavage fluid and lungs is reduced upon treatment with papain

increased susceptibility to bacterial infection ( J:282740 )

• mice exhibit a higher number of Salmonella typhimurium CFUs in the mesenteric lymph nodes than controls

• mice exhibit increased susceptibility to Citrobacter rodentium infection, showing increased bacterial CFUs in feces and spleen, accelerated weight loss, shortened colon length and persistent intestinal damage

Genotype
MGI:6513967

cn51

• Allelic Composition: Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

immune system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

hematopoietic system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

Genotype
MGI:6303639

cn52

• Allelic Composition: Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

decreased T cell number ( J:274048 )

• population of lymphoid cells in spleen is severely diminished

• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively

decreased alpha-beta T cell number ( J:274048 )

• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood

• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen

• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:274048 )

• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:274048 )

• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

immune system

decreased T cell number ( J:274048 )

• population of lymphoid cells in spleen is severely diminished

• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively

decreased alpha-beta T cell number ( J:274048 )

• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood

• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen

• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow

decreased CD4-positive, alpha-beta T cell number ( J:274048 )

• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology ( J:274048 )

• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

neoplasm

increased metastatic potential ( J:274048 )

• 14 days after tumor cell implantation, breast tumor cells metastasize to the lungs of mutant mice but not control mice

increased incidence of induced tumors ( J:274048 )

• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth and grow larger than in control mice implanted with tumor cells

• twice as many myeloid derived suppressor cells are present in the tumor microenvironment compared to controls

• fewer lymphoid cells are recruited to the tumor microenvironment compared to controls, with reduced CD3+CD19- T cell population due to reduced numbers of CD3+CD19-gamma-deltaTCR- alpha-beta T cells

• the tumor microenvironment shows a reduction in both CD4+ T helper cells and CD8+ cytotoxic T cell populations compared to controls

decreased tumor latency ( J:274048 )

• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth than in control mice implanted with tumor cells

Genotype
MGI:7281769

cn53

• Allelic Composition: Satb1^tm2Kos/Satb1^tm2Kos; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

premature death ( J:252606 )

• mice start to die around 24 weeks of age

• renal failure is cause of death

endocrine/exocrine glands

salivary gland degeneration ( J:252606 )

• autoimmune destruction of the salivary gland

decreased salivation ( J:252606 )

• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks

salivary gland inflammation ( J:252606 )

• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age

• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present

• number of B cells gradually increase and dominate in older mice

pancreas inflammation ( J:252606 )

• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen

immune system

salivary gland inflammation ( J:252606 )

• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age

• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present

• number of B cells gradually increase and dominate in older mice

pancreas inflammation ( J:252606 )

• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen

absent regulatory T cells ( J:252606 )

• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age

increased susceptibility to autoimmune disorder ( J:252606 )

• mice develop Sjogren's syndrome by 4 weeks of age, with females being more susceptible and presenting earlier onset of the disease than males

• mice show T cell-dominant immune cell infiltration in the salivary glands at 4 weeks and a gradual increase in the frequency of B cells, and an increase in anti-SSA and anti-SSB antibodies around 8 weeks of age

• transfer or T cells from mutant cervical lymph nodes, but not spleen, is sufficient to induce the development of Sjogren's syndrome in RAG2 null mice

• 3-day-old mice transferred with Treg cells derived from mature wild-type spleen show improved xerostomia, although saliva production is still reduced, a lesser degree of lymphocyte infiltration into salivary glands is seen and mice are protected against development of Sjogren's syndrome

• mice develop lupus nephritis

increased autoantibody level ( J:252606 )

• presence of anti-SSA and anti-SSB antibodies which are higher than in wild-type mice at 10 and 7 weeks of age, respectively

increased anti-nuclear antigen antibody level ( J:252606 )

• ANA are detected at high levels after 15 weeks of age

kidney inflammation ( J:252606 )

• mice develop lupus nephritis after failure of salivary gland function

digestive/alimentary system

salivary gland degeneration ( J:252606 )

• autoimmune destruction of the salivary gland

decreased salivation ( J:252606 )

• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks

salivary gland inflammation ( J:252606 )

• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age

• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present

• number of B cells gradually increase and dominate in older mice

hematopoietic system

absent regulatory T cells ( J:252606 )

• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age

homeostasis/metabolism

decreased salivation ( J:252606 )

• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks

increased urine protein level ( J:252606 )

• some mice exhibit proteinuria after 15 weeks of age

renal/urinary system

increased urine protein level ( J:252606 )

• some mice exhibit proteinuria after 15 weeks of age

kidney inflammation ( J:252606 )

• mice develop lupus nephritis after failure of salivary gland function

abnormal renal glomerulus morphology ( J:252606 )

• IgM and IgG deposition, most likely a part of immune complexes, is seen around the glomerulus in the kidneys at 15 weeks of age

• a component of complement C3 is present in association with Ig deposition, suggestions that kidney lesions resembling lupus nephritis develop in aged mice

• no kidney lesions are seen at 4-5 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:252606

Genotype
MGI:7311733

cn54

• Allelic Composition: A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:259392 )

N • mice exhibit normal development of innate lymphoid cell progenitors

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells

• however, ILC1 and ILC2s numbers are normal

Genotype
MGI:5564914

cn55

• Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:207383 )

N • granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow

decreased plasmacytoid dendritic cell number ( J:207383 )

• 10- to 50-fold reduction in bone marrow at 6 weeks of age

• also reduced in the spleen but not as severely as in the bone marrow

decreased B cell number ( J:207383 )

• 10- to 50-fold reduction in bone marrow at 6 weeks of age

• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen

decreased hematopoietic stem cell number ( J:207383 )

• about a 2-fold decrease in the bone marrow

immune system

decreased plasmacytoid dendritic cell number ( J:207383 )

• 10- to 50-fold reduction in bone marrow at 6 weeks of age

• also reduced in the spleen but not as severely as in the bone marrow

decreased B cell number ( J:207383 )

• 10- to 50-fold reduction in bone marrow at 6 weeks of age

• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen

decreased circulating interferon-alpha level ( J:207383 )

• following infection with human HSV strain 17

homeostasis/metabolism

decreased circulating interferon-alpha level ( J:207383 )

• following infection with human HSV strain 17

Genotype
MGI:5553469

cn56

• Allelic Composition: Tg(JAK2*V617F)FF1Rsko/0; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:134364 )

• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen

abnormal erythropoiesis ( J:134364 )

• bones are pale at 20 weeks of age, suggesting decreased erythropoiesis

• erythroid TER-119+ cells are reduced in the bone marrow but a compensatory increase is seen in the spleen at 20 weeks of age

abnormal myelopoiesis ( J:134364 )

• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age

extramedullary hematopoiesis ( J:134364 )

• liver shows extramedullary hematopoiesis at 20 weeks of age with highly atypical megakaryocytes, but islands with myelopoeisis and erythropoiesis are also seen

• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen

• hematopoietic cells, including megakaryocytes are seen in the lung at 20 weeks of age

increased bone marrow cell number ( J:134364 )

• bone marrow shows hypercellularity with trilineage hyperplasia at 20 weeks of age

increased megakaryocyte cell number ( J:134364 )

• increase in numbers of megakaryocytes in the spleen and bone marrow at 20 weeks of age, most with morphological abnormalities such as hyperchromatic, hyperlobulated nuclei, and bizarre nuclear configuration, and often forming clusters

increased erythroid progenitor cell number ( J:134364 )

• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen

abnormal megakaryocyte progenitor cell morphology ( J:134364 )

• collagen-based culture indicates a small increase in CFU-MK in bone marrow and a massive expansion of CFU-MK in the spleen

decreased hemoglobin content ( J:134364 )

• slight decrease in hemoglobin at 20 weeks of age but is normal at 10 weeks of age

increased neutrophil cell number ( J:134364 )

• slight increase in neutrophils at 10 and 20 weeks of age

thrombocytosis ( J:134364 )

• thrombocytosis is seen at 10 weeks of age, with a massive increase in platelets at 20 weeks of age

decreased B cell number ( J:134364 )

• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age

decreased T cell number ( J:134364 )

• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age

abnormal spleen morphology ( J:134364 )

• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age

enlarged spleen ( J:134364 )

spleen fibrosis ( J:134364 )

• seen at 20 weeks of age

immune system

abnormal myelopoiesis ( J:134364 )

• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age

increased neutrophil cell number ( J:134364 )

• slight increase in neutrophils at 10 and 20 weeks of age

decreased B cell number ( J:134364 )

• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age

decreased T cell number ( J:134364 )

• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age

abnormal spleen morphology ( J:134364 )

• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age

enlarged spleen ( J:134364 )

spleen fibrosis ( J:134364 )

• seen at 20 weeks of age

skeleton

abnormal bone marrow morphology ( J:134364 )

• dilated sinusoids with intrasinusoidal hematopoiesis are seen in the bone marrow at 20 weeks of age

• myeloid cells are the predominant cell population in the bone marrow

myelofibrosis ( J:134364 )

• presence of myelofibrosis at 20 weeks of age

growth/size/body

enlarged spleen ( J:134364 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
essential thrombocythemia		DOID:2224	OMIM:187950 OMIM:601977 OMIM:614521	J:134364

Genotype
MGI:5496264

cn57

• Allelic Composition: Gt(ROSA)26Sor^{tm2(CAG-PSTPIP1*)Dtg}/Gt(ROSA)26Sor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

behavior/neurological

behavior/neurological phenotype ( J:196002 )

N • mice exhibit normal behavior

growth/size/body

growth/size/body region phenotype ( J:196002 )

N • mice exhibit normal body weight

immune system

immune system phenotype ( J:196002 )

N • mice produce normal levels of proinflammatory cytokines when provoked with inflammasome-activating stimuli

Genotype
MGI:5496262

cn58

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

normal phenotype

no abnormal phenotype detected ( J:196002 )

• mice do not show any abnormalities

Genotype
MGI:5488604

cn59

• Allelic Composition: Cxcl12^tm1.1Sjm/Cxcl12^tm1.1Sjm; Commd10^{Tg(Vav1-icre)A2Kio}/?
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:194748 )

N • normal cellularity and hematopoietic stem cell frequency

N • bone marrow/spleen lineage composition is normal

Genotype
MGI:5438280

cn60

• Allelic Composition: Idh1^tm2Mak/Idh1^tm2Mak; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:186700 )

N • mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers

abnormal common myeloid progenitor cell morphology ( J:186700 )

• increase in common lymphocyte progenitor cells in the bone marrow and spleen

abnormal common lymphocyte progenitor cell morphology ( J:186700 )

• increase in megakaryocyte-erythroid progenitors in the spleen

increased hematopoietic stem cell number ( J:186700 )

• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen

• increase in LK in the spleen

Genotype
MGI:4942367

cn61

• Allelic Composition: Tg(Kit*D814V)1Roer/0; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

mortality/aging

neonatal lethality ( J:169611 )

• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)1Roer

Genotype
MGI:5301602

cn62

• Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

Increased spleen size in Rc3h1^tm1.1Mass/Rc3h1^tm1.1MassCommd10^{Tg(Vav1-icre)A2Kio}/0 mice

immune system

immune system phenotype ( J:177784 )

N • mice exhibit normal T cell development and autoimmunity

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

hematopoietic system

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

decreased bone marrow cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

growth/size/body

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

Genotype
MGI:6267349

cn63

• Allelic Composition: Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca

hematopoietic system

abnormal bone marrow cell morphology/development ( J:266848 )

• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell

decreased bone marrow cell number ( J:266848 )

• modest reduction in pIpC-treated mice

decreased hematopoietic stem cell number ( J:266848 )

• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells

Genotype
MGI:6696062

cn64

• Allelic Composition: Zbtb38^em1Dbhat/Zbtb38^em1Dbhat; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca

immune system

immune system phenotype ( J:296556 )

N • mice exhibit normal normal hematopoietic cell development, primary antibody responses to hapten-protein antigens, and secondary B cell responses

Genotype
MGI:5902764

cn65

• Allelic Composition: Brpf1^{tm1c(EUCOMM)Wtsi}/Brpf1^{tm1c(EUCOMM)Wtsi}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
• Cell Lines: EPD0069_1_G06

cellular

abnormal cell physiology ( J:240552 )

• reduced histone H3K23 acetylation in thymus and spleen extracts

Genotype
MGI:6267348

cn66

• Allelic Composition: Chaf1b^{tm2c(EUCOMM)Hmgu}/Chaf1b^{tm2c(EUCOMM)Hmgu}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca

mortality/aging

prenatal lethality, complete penetrance ( J:266848 )

• no viable mice are produced

Genotype
MGI:6712737

cn67

• Allelic Composition: Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll; Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6N * C57BL/10 * CBA/Ca

hematopoietic system

hematopoietic system phenotype ( J:305794 )

N • mice show an improvement in peripheral blood red blood cell numbers and hematocrit levels, and an increase in RIII and RIV erythroid precursors in the bone marrow compared to Il22ra1-sufficient Riok2-haploinsufficent mice

Genotype
MGI:5604905

cn68

• Allelic Composition: Jagn1^{tm1c(EUCOMM)Hmgu}/Jagn1^{tm1c(EUCOMM)Hmgu}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6N * C57BL/10 * CBA/Ca

immune system

abnormal neutrophil morphology ( J:214828 )

• neutrophils show reduced numbers of primary and secondary granules

• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity

• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood

abnormal neutrophil physiology ( J:214828 )

• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans

• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans

impaired neutrophil chemotaxis ( J:214828 )

• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)

impaired neutrophil recruitment ( J:214828 )

• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection

increased susceptibility to fungal infection ( J:214828 )

• mice are unable to mount an efficient neutrophil-dependent immune response to the human fungal pathogen Candida albicans, showing increased weight loss, massively increased fungal burdens, severe multifocal tubulointerstitial nephritis, splenitis with expanded white pulp, diffuse inflammatory infiltrations into the liver and lungs, and decreased TNF-alpha levels in the serum and intraperitonal lavage and succumb earlier to Candida albicans infection

• treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF) protects mutants from weight loss, rescues the neutrophil recruitment defects and increases survival after Candida albicans challenge

cellular

impaired neutrophil chemotaxis ( J:214828 )

• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)

hematopoietic system

abnormal neutrophil morphology ( J:214828 )

• neutrophils show reduced numbers of primary and secondary granules

• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity

• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood

abnormal neutrophil physiology ( J:214828 )

• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans

• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans

impaired neutrophil chemotaxis ( J:214828 )

• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)

impaired neutrophil recruitment ( J:214828 )

• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection

Genotype
MGI:6712638

cn69

• Allelic Composition: Riok2^{tm1c(KOMP)Wtsi}/Riok2⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6N * C57BL/10 * CBA/Ca

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:305794 )

• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls

hematopoietic system

abnormal erythropoiesis ( J:305794 )

• mice exhibit impaired erythropoiesis in the bone marrow

anemia ( J:305794 )

• mice over 60 weeks of age exhibit anemia

• 8-12 week of mice exposed to acute hemolytic stress (induced by nonlethal phenylhydrazine treatment) develop more severe anemia and have a delayed red blood cell recovery response compared to controls and succumb faster to a lethal dose of phenylhydrazine

• wild-type mice transplanted with mutant whole bone marrow develop anemia

• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia

increased granulocyte monocyte progenitor cell number ( J:305794 )

• the percentage of proliferating granulocyte-macrophage progenitors in the bone marrow is increased

decreased erythroid progenitor cell number ( J:305794 )

• anemia in young phenylhydrazine-administered mice seen on day 7 is preceded by a reduction in bone marrow RIII and RIV erythroid precursor frequency on day 6, indicating an erythroid differentiation defect

decreased erythrocyte cell number ( J:305794 )

• aged mice exhibit reduced peripheral blood red blood cell numbers

decreased hematocrit ( J:305794 )

• in aged mice

decreased hemoglobin content ( J:305794 )

• in aged mice

decreased neutrophil cell number ( J:305794 )

• mice exhibit a decreased percentage of neutrophils (neutropenia)

increased NK T cell number ( J:305794 )

• aged mice show increased numbers of natural killer T cells

increased monocyte cell number ( J:305794 )

• mice exhibit an increased percentage of monocytes (monocytosis)

increased myeloid cell number ( J:305794 )

• LSK (lineage^-Sca-1⁺Kit⁺) cells from the bone marrow supplemented with growth factors give rise to an increased percentage of CD11b+ myeloid cells, indicating a cell-intrinsic myeloproliferative effect

increased hematopoietic stem cell number ( J:305794 )

• frequency and numbers of early hematopoietic progenitors are normal in young mice, however long-term hematopoietic stem cells (LT-HSCs) are increased in the bone marrow of aged mice

abnormal CD4-positive, alpha beta T cell morphology ( J:305794 )

• aged mice show increased numbers of splenic IL-22+CD4+T cells

abnormal hematopoietic system physiology ( J:305794 )

• mice exhibit an increase in apoptosis of erythroid precursors

• erythroid precursors show a decrease in cell quiescence with cell cycle block at the G1 phase

• treatment of mice with a neutralizing IL-22 antibody reduces the frequency of apoptotic erythroid precursors

abnormal CD4-positive, alpha-beta T cell physiology ( J:305794 )

• TH22 cells secrete elevated concentrations of IL-22

abnormal bone marrow cell physiology ( J:305794 )

• bone marrow cells show reduced nascent protein synthesis in vivo

homeostasis/metabolism

abnormal circulating interleukin level ( J:305794 )

• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:305794 )

• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls

increased physiological sensitivity to xenobiotic ( J:305794 )

• 8-12 week of mice exposed to acute hemolytic stress induced by nonlethal phenylhydrazine treatment develop more severe anemia and have a delayed red blood cell recovery response compared to controls

• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia

immune system

abnormal CD4-positive, alpha-beta T cell physiology ( J:305794 )

• TH22 cells secrete elevated concentrations of IL-22

abnormal circulating interleukin level ( J:305794 )

• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls

abnormal immune system morphology ( J:305794 )

• aged mice show increased numbers of innate lymphoid cells

decreased neutrophil cell number ( J:305794 )

• mice exhibit a decreased percentage of neutrophils (neutropenia)

increased NK T cell number ( J:305794 )

• aged mice show increased numbers of natural killer T cells

increased monocyte cell number ( J:305794 )

• mice exhibit an increased percentage of monocytes (monocytosis)

abnormal CD4-positive, alpha beta T cell morphology ( J:305794 )

• aged mice show increased numbers of splenic IL-22+CD4+T cells

abnormal interleukin secretion ( J:305794 )

• naive T cells polarized toward the TH22 cell lineage show an increase in IL-22 secretion

Genotype
MGI:6712637

cn70

• Allelic Composition: Riok2^{tm1c(KOMP)Wtsi}/Riok2^{tm1c(KOMP)Wtsi}; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6N * C57BL/10 * CBA/Ca

mortality/aging

prenatal lethality, complete penetrance ( J:305794 )

• no homozygous mice are recovered

Genotype
MGI:5908557

cn71

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/?; Tnfrsf14^tm1.1Kro/Tnfrsf14^tm1.1Kro
• Genetic Background: involves: C57BL/6NCrl * C57BL/10 * CBA * SJL

immune system

decreased susceptibility to Herpesvirales infection ( J:243038 )

♂ • following corneal inoculation of HSV1, corneas have lower viral titers as compared to controls

♂ • myeloid cell infiltration into the cornea 14 days post HSV1 infection is reduced as compared to controls

behavior/neurological

abnormal blinking ( J:243038 )

♂ • following corneal inoculation of HSV1, corneal reflexes (as measured by corneal touch threshold) are largely retained in contrast to infected controls

Genotype
MGI:6367554

cn72

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺; Ociad1^tm1Msin/Ociad1^tm1Msin
• Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

hematopoietic system

increased hematopoietic cell number ( J:279239 )

• increase in peripheral blood cell numbers

increased hematopoietic stem cell number ( J:279239 )

• increase in hematopoietic stem cell frequencies

Genotype
MGI:5295638

cn73

• Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

hematopoietic system

decreased common myeloid progenitor cell number ( J:176843 )

• reduction in most myeloid progenitors

• numbers of myeloid subsets CD11b⁺Gr1^- and CD11b^-Gr1⁺ are reduced in blood and decrease further over time

decreased bone marrow cell number ( J:176843 )

• overall bone marrow cell count is reduced

abnormal common lymphocyte progenitor cell morphology ( J:176843 )

• common lymphoid progenitors (Lin^-Flt3^HighIL7Ra^HighSca-1^Lowc-Kit^Low) are reduced in mutants

• numbers of CCR9⁺ lymphoid-primed multipotent progenitors are reduced in the bone marrow of mutants

abnormal hematopoietic stem cell morphology ( J:176843 )

• mutant LSK (Lin^-Sca-1⁺c-Kit⁺) cells accumulate mitochondria, mitochondrial superoxide, and DNA damage and exhibit increased levels of apoptosis and proliferation

decreased hematopoietic stem cell number ( J:176843 )

• numbers of hematopoietic stem cells are reduced in all mutants, regardless of disease progression

• absolute numbers of LSK (Lin^-Sca-1⁺c-Kit⁺) cells significantly increased in asymptomatic 7 week old mutants, however as they develop symptoms, the frequency of LSK cells falls to wild-type levels

• the Lin^-Sca-1^-c-Kit⁺ (LK) compartment, containing more mature hematopoietic progenitors, is decreased

abnormal leukocyte morphology ( J:176843 )

• numbers of CD11b⁺Gr1⁺ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age

• CD11b⁺Gr1⁺ cells in the spleen and bone marrow are increased and show higher proliferation rates

• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs

decreased leukocyte cell number ( J:176843 )

• mutants are cytopenic for all blood leukocyte populations except for CD11b⁺Gr1⁺ cells

decreased B cell number ( J:176843 )

• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

decreased NK cell number ( J:176843 )

• immature NK cells (Lin^-CD3^-CD122⁺NK1.1⁺DX5⁺) are depleted in the bone marrow

• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

decreased T cell number ( J:176843 )

• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

abnormal hematopoietic stem cell physiology ( J:176843 )

• adult bone marrow cells from mutants transplanted together with CD45.1⁺ wild-type bone marrow cells into lethally irradiated wild-type hosts fail to contribute to reconstitution of cells in the hosts while in noncompetitive reconstitution experiments, lethally irradiated mice die within 4 weeks after transplantation with mutant bone marrow cells, indicating loss of hematopoietic stem cell activity

immune system

abnormal leukocyte morphology ( J:176843 )

• numbers of CD11b⁺Gr1⁺ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age

• CD11b⁺Gr1⁺ cells in the spleen and bone marrow are increased and show higher proliferation rates

• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs

decreased leukocyte cell number ( J:176843 )

• mutants are cytopenic for all blood leukocyte populations except for CD11b⁺Gr1⁺ cells

decreased B cell number ( J:176843 )

• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

decreased NK cell number ( J:176843 )

• immature NK cells (Lin^-CD3^-CD122⁺NK1.1⁺DX5⁺) are depleted in the bone marrow

• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

decreased T cell number ( J:176843 )

• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myelodysplastic syndrome		DOID:0050908	OMIM:614286	J:176843

Genotype
MGI:5527435

cn74

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

mortality/aging

preweaning lethality, incomplete penetrance ( J:203163 )

• fewer than expected mice are observed at P10

hematopoietic system

abnormal hematopoietic system morphology/development ( J:203163 )

• disturbed hematopoietic development in adult hematopoietic progenitor cells

anemia ( J:203163 )

• severe in some mice

abnormal bone marrow cell morphology/development ( J:203163 )

• reduced total number of colony forming units from bone marrow cells

decreased common myeloid progenitor cell number ( J:203163 )

• in bone marrow cells

decreased erythroid progenitor cell number ( J:203163 )

• in bone marrow cells

Genotype
MGI:6712735

cx75

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm1Tyj; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca

immune system

abnormal interleukin secretion ( J:305794 )

• naive T cells polarized toward the TH22 cell lineage show a decrease in IL-22 secretion

Genotype
MGI:6712736

cx76

• Allelic Composition: Il22^tm1.1Lex/Il22^tm1.1Lex; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca

hematopoietic system

increased erythrocyte cell number ( J:305794 )

• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress