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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou2f3tm1Rsd
targeted mutation 1, Michael G Rosenfeld
MGI:2450109
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pou2f3tm1Rsd/Pou2f3tm1Rsd involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:2655767
cx2
 		Pou2f3tm1Rsd/Pou2f3tm1Rsd
Pou3f1tm1Rsd/Pou3f1tm1Rsd 		involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:2665472


Genotype
MGI:2655767
hm1
Allelic
Composition		 Pou2f3tm1Rsd/Pou2f3tm1Rsd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f3tm1Rsd mutation (0 available); any Pou2f3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:42016 )
N
• skin and coat appeared grossly normal
abnormal keratinocyte differentiation ( J:42016 )
• abnormal epidermal layer: defective keratinocyte differentiation

cellular
abnormal keratinocyte differentiation ( J:42016 )
• abnormal epidermal layer: defective keratinocyte differentiation




Genotype
MGI:2665472
cx2
Allelic
Composition		 Pou2f3tm1Rsd/Pou2f3tm1Rsd
Pou3f1tm1Rsd/Pou3f1tm1Rsd
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f3tm1Rsd mutation (0 available); any Pou2f3 mutation (34 available)
Pou3f1tm1Rsd mutation (0 available); any Pou3f1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:42016 )
• most mice die soon after birth

integument
integument phenotype ( J:42016 )
N
• no overt skin abnormalities in neonates




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory