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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zfxtm1Dcp
targeted mutation 1, David C Page
MGI:2450147
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zfxtm1Dcp/Zfxtm1Dcp involves: 129S4/SvJae * BALB/c MGI:2653291
hm2
Zfxtm1Dcp/Zfxtm1Dcp involves: 129S4/SvJae * C57BL/6J MGI:2653292
ht3
Zfxtm1Dcp/Zfx+ involves: 129S4/SvJae * BALB/c MGI:2653290
ht4
Zfxtm1Dcp/Zfx+ involves: 129S4/SvJae * C57BL/6J MGI:2653289
ot5
Zfxtm1Dcp/Y involves: 129S4/SvJae * BALB/c MGI:2653287
ot6
Zfxtm1Dcp/Y involves: 129S4/SvJae * C57BL/6J MGI:2653288


Genotype
MGI:2653291
hm1
Allelic
Composition
Zfxtm1Dcp/Zfxtm1Dcp
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 90% died in the neonatal period

embryo
• 20% reduction in body size relative to heterozygous female embryos

endocrine/exocrine glands

growth/size/body
• 20% reduction in body size relative to heterozygous female embryos
• 20% to 30% reduction in body size relative to heterozygous females
• growth disturbance originates prior to E12.5

reproductive system
• oocyte deficit exists at 4-5 days after birth therefore independent of reproductive cycling
• oocyte deficit is one eighth the number in +/+ females
• reduced number of primordial germ cells at E11.5
• shortened reproductive lifespan
• only 31% of females mated produced litters
• litter size averaged 4 compared to 6 produced by +/- females

cellular
• oocyte deficit exists at 4-5 days after birth therefore independent of reproductive cycling
• oocyte deficit is one eighth the number in +/+ females
• reduced number of primordial germ cells at E11.5




Genotype
MGI:2653292
hm2
Allelic
Composition
Zfxtm1Dcp/Zfxtm1Dcp
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:2653290
ht3
Allelic
Composition
Zfxtm1Dcp/Zfx+
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 50% died in the neonatal period

reproductive system
• at 4-5 days after birth total is signficantly less than found in +/+ littermates

cellular
• at 4-5 days after birth total is signficantly less than found in +/+ littermates




Genotype
MGI:2653289
ht4
Allelic
Composition
Zfxtm1Dcp/Zfx+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 50% of the offspring died prior to weaning




Genotype
MGI:2653287
ot5
Allelic
Composition
Zfxtm1Dcp/Y
Genetic
Background
involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 90% died in the neonatal period

embryo
• 20% reduction in body size relative to wild-type male embryos

growth/size/body
• 20% reduction in body size relative to wild-type male embryos
• 20% to 25% reduction in body size relative to wild-type males
• growth disturbance originates prior to E12.5

reproductive system
• sperm counts were half those of wild-type
• reduced number of primordial germ cells at E11.5

cellular
• sperm counts were half those of wild-type
• reduced number of primordial germ cells at E11.5




Genotype
MGI:2653288
ot6
Allelic
Composition
Zfxtm1Dcp/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfxtm1Dcp mutation (0 available); any Zfx mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice died prior to weaning





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory