Analysis Tools
behavior/neurological
limb grasping
(
J:62566
)
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• hindlimb clasping when lifted by the tail is seen between the ages of 4 and 6 weeks with slight tremors as well in some animals
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abnormal gait
(
J:62566
)
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• unsteady gait by 6-9 months of age
• difficulty supporting themselves on their hind limbs
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• lower threshold for response using von Frey hairs on hind paws
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• lower thermal nociceptive thresholds
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growth/size/body
weight loss
(
J:62566
)
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• rapid weight loss due to inability to eat
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respiratory system
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• labored breathing
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nervous system
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• growth rate of schwann cells is lower than the extension rate of their axons
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• at 6 weeks of age, sciatic nerves display focal thickening and infoldings of internodal myelin
• demyelination
• by 6 months of age, extensive demyelination has occurred in sensory, motor, and autonomic nerves with focal thickening in internodes and axonal sheath disruption
• unmyelinated C fiber bundles are morphologically normal
• remyelination after injury is retarded even in younger mice
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• reduced action potentials
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• reduced conduction velocity
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