Analysis Tools
mortality/aging
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• mice reared on standard lab chow died prematurely due to a feeding impairment
• however, a soft-dough diet allowed all mice to survive >3 months and into adulthood
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behavior/neurological
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• mice reared on standard lab chow displayed compromised feeding due to tooth defects
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growth/size/body
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• molars dislodged during skull preparations of adult maxillae and mandibles, unlike in wild-type controls
• adult molar tooth sockets were shallow and contained an unorganized mesh of bony spicules
• at P15, no alveolar bone formation was seen in molar tooth sockets, unlike in wild-type controls
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• thin and highly disorganized mandibular (lower) incisors, frequently showing scattered pockets of differentiated tissue
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• grossly asymmetric maxillary incisors with near-normal labial dentin and enamel deposition but nearly absent lingual dentin deposition
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• overgrown, thin maxillary (upper) incisors
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• mice exhibited virtually no mandibular (lower) incisors
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• all adult molar teeth had normal crowns but no roots
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• all adult molar teeth lacked roots
• lack of roots was observed bilaterally
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• mice displayed abnormal incisor and molar root development, associated with reduced tooth-specific gene expression
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• at P14, molar roots failed to form, unlike in wild-type controls; however, molar crown formation was normal
• no structural changes were observed in the jaw, suggesting failure at either the initial outgrowth of the epithelial sheath or during early extension of the molar root
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• maxillary incisors showed near-normal labial dentin deposition but displayed near absent lingual dentin deposition
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brittle teeth
(
J:81645
)
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• thin and brittle mandibular incisors
• weakened abnormal maxillary incisors
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• mice reared on standard lab chow became severely runted after weaning
• continued rearing on standard lab chow resulted in further runting and premature death
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craniofacial
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• molars dislodged during skull preparations of adult maxillae and mandibles, unlike in wild-type controls
• adult molar tooth sockets were shallow and contained an unorganized mesh of bony spicules
• at P15, no alveolar bone formation was seen in molar tooth sockets, unlike in wild-type controls
|
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• thin and highly disorganized mandibular (lower) incisors, frequently showing scattered pockets of differentiated tissue
|
|
• grossly asymmetric maxillary incisors with near-normal labial dentin and enamel deposition but nearly absent lingual dentin deposition
|
|
• overgrown, thin maxillary (upper) incisors
|
|
• mice exhibited virtually no mandibular (lower) incisors
|
|
• all adult molar teeth had normal crowns but no roots
|
|
• all adult molar teeth lacked roots
• lack of roots was observed bilaterally
|
|
• mice displayed abnormal incisor and molar root development, associated with reduced tooth-specific gene expression
|
|
• at P14, molar roots failed to form, unlike in wild-type controls; however, molar crown formation was normal
• no structural changes were observed in the jaw, suggesting failure at either the initial outgrowth of the epithelial sheath or during early extension of the molar root
|
|
• maxillary incisors showed near-normal labial dentin deposition but displayed near absent lingual dentin deposition
|
brittle teeth
(
J:81645
)
|
• thin and brittle mandibular incisors
• weakened abnormal maxillary incisors
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• mandibles were ~10% smaller than normal
• however, size of maxillae was normal
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skeleton
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• molars dislodged during skull preparations of adult maxillae and mandibles, unlike in wild-type controls
• adult molar tooth sockets were shallow and contained an unorganized mesh of bony spicules
• at P15, no alveolar bone formation was seen in molar tooth sockets, unlike in wild-type controls
|
|
• thin and highly disorganized mandibular (lower) incisors, frequently showing scattered pockets of differentiated tissue
|
|
• grossly asymmetric maxillary incisors with near-normal labial dentin and enamel deposition but nearly absent lingual dentin deposition
|
|
• overgrown, thin maxillary (upper) incisors
|
|
• mice exhibited virtually no mandibular (lower) incisors
|
|
• all adult molar teeth had normal crowns but no roots
|
|
• all adult molar teeth lacked roots
• lack of roots was observed bilaterally
|
|
• mice displayed abnormal incisor and molar root development, associated with reduced tooth-specific gene expression
|
|
• at P14, molar roots failed to form, unlike in wild-type controls; however, molar crown formation was normal
• no structural changes were observed in the jaw, suggesting failure at either the initial outgrowth of the epithelial sheath or during early extension of the molar root
|
|
• maxillary incisors showed near-normal labial dentin deposition but displayed near absent lingual dentin deposition
|
brittle teeth
(
J:81645
)
|
• thin and brittle mandibular incisors
• weakened abnormal maxillary incisors
|
|
• mandibles were ~10% smaller than normal
• however, size of maxillae was normal
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reproductive system
| N |
• well-nourished mice fed a soft-dough diet mated successfully and produced litters of normal size
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