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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csnk2btm1.2Bb
targeted mutation 1.2, Brigitte Boldyreff
MGI:2450158
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Csnk2btm1.2Bb/Csnk2btm1.2Bb involves: 129S2/SvPasCrl * C57BL/6 MGI:3720792
cn2
 		Csnk2btm1.1Bb/Csnk2btm1.2Bb
Tg(Stra8-icre)1Reb/0 		involves: 129S2/SvPasCrl * C57BL/6 * FVB/NJ MGI:6845052


Genotype
MGI:3720792
hm1
Allelic
Composition		 Csnk2btm1.2Bb/Csnk2btm1.2Bb
Genetic
Background		 involves: 129S2/SvPasCrl * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk2btm1.2Bb mutation (0 available); any Csnk2b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:81637 )
• embryonic development arrests at E6.5
embryonic growth retardation ( J:81637 )
• embryos exhibit growth retardation prior to E6.5
decreased embryo size ( J:81637 )
• embryos are smaller at E6.5
absent inner cell mass ( J:81637 )
• embryos collected at E2.5 and cultured for 7 days fail to form an inner cell mass
abnormal trophoblast giant cell morphology ( J:81637 )
• embryos collected at E2.5 and cultured for 7 days exhibit degeneration of trophoblast cells

growth/size/body
embryonic growth retardation ( J:81637 )
• embryos exhibit growth retardation prior to E6.5
decreased embryo size ( J:81637 )
• embryos are smaller at E6.5




Genotype
MGI:6845052
cn2
Allelic
Composition		 Csnk2btm1.1Bb/Csnk2btm1.2Bb
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129S2/SvPasCrl * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk2btm1.1Bb mutation (0 available); any Csnk2b mutation (14 available)
Csnk2btm1.2Bb mutation (0 available); any Csnk2b mutation (14 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:289955 )
• no round or elongated spermatids are detected in seminiferous tubules at 2 months of age
abnormal spermatocyte morphology ( J:289955 )
• numbers of leptotene, zygotene and pachytene spermatocytes are significantly reduced in juvenile males
• numbers of zygotene, pachytene and diplotene spermatocytes are significantly decreased at 2 months of age
• however, numbers of spermatogonia and leptotene spermatocytes are normal at 2 months of age
decreased male germ cell number ( J:289955 )
• number of germ cells per seminiferous tubule is significantly lower than that in controls at 12 dpp, 15 dpp and 17 dpp (corresponding to leptotene, zygotene and pachytene spermatocytes, respectively), and remains almost unchanged from 12 dpp to 17 dpp, unlike in control testes
• number of MVH-positive germ cells is dramatically reduced at 2 months of age
azoospermia ( J:289955 )
• no mature spermatozoa are present in the cauda epididymal lumens at 2 months of age
increased male germ cell apoptosis ( J:289955 )
• number of TUNEL+ germ cells per seminiferous tubule is significantly increased at 2 months of age
increased testis apoptosis ( J:289955 )
• more than 50% of the seminiferous tubules are TUNEL+ compared with less than 20% in control males
abnormal seminiferous tubule morphology ( J:289955 )
• seminiferous tubules contain only a few spermatocytes at 12 dpp, 15 dpp and 17 dpp
• only a few germ cells and no round or elongated spermatids are detected in seminiferous tubules at 2 months of age
small seminiferous tubules ( J:289955 )
• seminiferous tubule diameter is reduced to half of that in control males at 2 months of age
small testis ( J:289955 )
• testis size is markedly smaller at 2 months of age
decreased testis weight ( J:289955 )
• testis weight-to-body weight ratio shows only small changes from day 12 to month 12 after birth and remains lower than that in controls at all ages examined
testicular atrophy ( J:289955 )
• males develop testicular atrophy that does not change with increasing age after adulthood
arrest of spermatogenesis ( J:289955 )
• first wave of spermatogenesis is severely blocked
male infertility ( J:289955 )
• 8-week-old male mice fail to produce offspring during a 6-month mating period with wild-type females of known fertility

cellular
abnormal spermatid morphology ( J:289955 )
• no round or elongated spermatids are detected in seminiferous tubules at 2 months of age
abnormal spermatocyte morphology ( J:289955 )
• numbers of leptotene, zygotene and pachytene spermatocytes are significantly reduced in juvenile males
• numbers of zygotene, pachytene and diplotene spermatocytes are significantly decreased at 2 months of age
• however, numbers of spermatogonia and leptotene spermatocytes are normal at 2 months of age
decreased male germ cell number ( J:289955 )
• number of germ cells per seminiferous tubule is significantly lower than that in controls at 12 dpp, 15 dpp and 17 dpp (corresponding to leptotene, zygotene and pachytene spermatocytes, respectively), and remains almost unchanged from 12 dpp to 17 dpp, unlike in control testes
• number of MVH-positive germ cells is dramatically reduced at 2 months of age
azoospermia ( J:289955 )
• no mature spermatozoa are present in the cauda epididymal lumens at 2 months of age
increased male germ cell apoptosis ( J:289955 )
• number of TUNEL+ germ cells per seminiferous tubule is significantly increased at 2 months of age
increased testis apoptosis ( J:289955 )
• more than 50% of the seminiferous tubules are TUNEL+ compared with less than 20% in control males

endocrine/exocrine glands
increased testis apoptosis ( J:289955 )
• more than 50% of the seminiferous tubules are TUNEL+ compared with less than 20% in control males
abnormal seminiferous tubule morphology ( J:289955 )
• seminiferous tubules contain only a few spermatocytes at 12 dpp, 15 dpp and 17 dpp
• only a few germ cells and no round or elongated spermatids are detected in seminiferous tubules at 2 months of age
small seminiferous tubules ( J:289955 )
• seminiferous tubule diameter is reduced to half of that in control males at 2 months of age
small testis ( J:289955 )
• testis size is markedly smaller at 2 months of age
decreased testis weight ( J:289955 )
• testis weight-to-body weight ratio shows only small changes from day 12 to month 12 after birth and remains lower than that in controls at all ages examined
testicular atrophy ( J:289955 )
• males develop testicular atrophy that does not change with increasing age after adulthood

homeostasis/metabolism
abnormal protein level ( J:289955 )
• Csnk2a2 mRNA expression and CSNK2A2 protein level is significantly decreased in testes




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11/12/2024
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