All Phenotypes Mfn2<tm1Dcc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mfn2^tm1Dcc
targeted mutation 1, David C Chan
MGI:2450306

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfn2^tm1Dcc/Mfn2^tm1Dcc	involves: 129S/SvEv	MGI:3578770
cn2	Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779084
cn3	Gabra6^tm2(cre)Wwis/Gabra6⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779097
cn4	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779091
cn5	Mfn2^tm1Dcc/Mfn2^tm3Dcc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779094
cn6	En1^tm2(cre)Wrst/En1⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779095
cn7	Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0	involves: 129 * 129S4/SvJaeSor * Black Swiss	MGI:3779096
cn8	Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(EIIa-cre)C5379Lmgd/0	involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N	MGI:3779092
cn9	Meox2^tm1(cre)Sor/Meox2⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779093
cn10	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779088
cn11	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm2Dcc/Mfn1⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss	MGI:3779089
cx12	Mfn1^tm1Dcc/Mfn1^tm1Dcc Mfn2^tm1Dcc/Mfn2^tm1Dcc	involves: 129S/SvEv	MGI:3578771

Allelic Composition	Mfn2^tm1Dcc/Mfn2^tm1Dcc
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defective giant cell layer of Mfn2^tm1Dcc/Mfn2^tm1Dcc placenta

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:81438 )

• frequency of homozygous embryos normal up to E9.5

• 29% of homozygotes resorbed at E10.5

• 87% of homozygotes resorbed at E11.5

embryo

decreased embryo size ( J:81438 )

• embryos slightly smaller than littermates between E9.5 and E10.5 embryos slightly smaller than littermates between E9.5 and E10.5

abnormal trophoblast layer morphology ( J:81438 )

• smaller nuclei

decreased trophoblast giant cell number ( J:81438 )

• reduced numbers of trophoblast giant cells

• form an incomplete layer only one cell layer thick in placentas from E8.5-E10.5

cellular

abnormal mitochondrial morphology ( J:81438 )

• spherical or oval shaped mitochondria

• with cristae and a double membrane

abnormal mitochondrial physiology ( J:81438 )

• individual mitochondria functionally defective

• fewer mitochondrial fusion events observed

• mobility impaired secondary to abnormalities in shape

growth/size/body

decreased embryo size ( J:81438 )

• embryos slightly smaller than littermates between E9.5 and E10.5 embryos slightly smaller than littermates between E9.5 and E10.5

Allelic Composition	Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial morphology ( J:132329 )

• fibroblast derived from mutant animals exhibit Cre-dependent mitochondrial fragmentation

• loss of mtDNA nucleoids from a significant fraction of mitochondria

Allelic Composition	Gabra6^tm2(cre)Wwis/Gabra6⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabra6^tm2(cre)Wwis mutation (2 available); any Gabra6 mutation (39 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132329 )

• shows no defect in balance and coordination

• no anatomical abnormality in cerebella

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (45 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (45 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:132329 )

• Purkinje cell death in 9 weeks-old mutant mice cerebella

abnormal Purkinje cell dendrite morphology ( J:132329 )

• Purkinje cell dendrite attenuation in 9 weeks-old mutant mice cerebella

cellular

abnormal respiratory electron transport chain ( J:132329 )

• decreased cytochrome C oxidase activity and increased succinate dehydrogenase activity in Purkinje cells of 9-weeks-old mutant mice indicating the electron transport chain dysfunction in mitochondria

Allelic Composition	Mfn2^tm1Dcc/Mfn2^tm3Dcc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:132329 )

• mutant pups are born at appropriate Mendelian ratio

• after birth, about one third of mutant mice die on postnatal day 1

• all remaining mutant mice die by P17

behavior/neurological

impaired righting response ( J:132329 )

• mice surviving beyond P1 cannot easily regain posture when placed on their backs

impaired limb coordination ( J:132329 )

• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body

decreased body size ( J:132329 )

• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

nervous system

small cerebellum ( J:132329 )

• severe defect in postnatal cerebellar growth

Allelic Composition	En1^tm2(cre)Wrst/En1⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:132329 )

• mutant pups are born at appropriate Mendelian ratio

• after birth, about one third of mutant mice die on postnatal day 1

• all remaining mutant mice die by P17

behavior/neurological

impaired righting response ( J:132329 )

• mice surviving beyond P1 cannot easily regain posture when placed on their backs

impaired limb coordination ( J:132329 )

• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body

decreased body size ( J:132329 )

• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

nervous system

abnormal neuron mitochondrial morphology ( J:132329 )

• mitochondria in mutant Purkinje cells in mixed cerebellar cultures tend to cluster together in the cell body and do not enter the dendritic tracts

increased neuron apoptosis ( J:132329 )

• markedly higher levels of apoptosis in mutant cerebella as early as p6 and continuing through the second postnatal week

Purkinje cell degeneration ( J:132329 )

• widespread loss of Purkinje cell bodies py P15 resulting in reduction of the molecular layer

• Purkinje cell loss due to a degenerative process in mixed cerebellar cultures

abnormal Purkinje cell dendrite morphology ( J:132329 )

• reduced growth and deterioration of Purkinje cell dendrite during the second postnatal week

small cerebellum ( J:132329 )

• severe defect in postnatal cerebellar growth

• between P7 and P16, the mutant cerebellum reduces in size

• lobular organization and formation of the three cellular layers is relatively intact

cellular

abnormal neuron mitochondrial morphology ( J:132329 )

• mitochondria in mutant Purkinje cells in mixed cerebellar cultures tend to cluster together in the cell body and do not enter the dendritic tracts

increased neuron apoptosis ( J:132329 )

• markedly higher levels of apoptosis in mutant cerebella as early as p6 and continuing through the second postnatal week

Allelic Composition	Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:132329 )

• a progressive decline in coordination and balance in rotarod test

abnormal gait ( J:132329 )

• at 2 months of age, they begin to exhibit a slightly shaky gait

• mutants are indistinguishable from wild-type littermates first 2 mo

nervous system

abnormal cerebellum morphology ( J:132329 )

• obvious neuro-degeneration of cerebella over time

abnormal Purkinje cell mitochondrial morphology ( J:132329 )

• ultrastructurally the mitochondria in mutant Purkinje cells shows dramatic defects in mitochondrial morphology, distribution, and cristae organization

Purkinje cell degeneration ( J:132329 )

• the dendrites and death of Purkinje cell bodies resulting in very few surviving Purkinje cells by 3 months

• essentially all Purkinje cells are gone at 6 months of age

abnormal Purkinje cell focal axonal swelling ( J:132329 )

• by 7 weeks, Purkinje cell axons show extensive torpedoes, focal swellings typical of many neuropathies

abnormal Purkinje cell dendrite morphology ( J:132329 )

• Purkinje cell dendrite attenuation in 9 weeks-old mutant mice cerebella

small cerebellum ( J:132329 )

• by 3 months of age, the mutant cerebella are only 75% that of wild-type

• by 1 year of age, the overall cerebellar area of mutants has dropped to 50% of wild-type

• the greatest loss occurs in the molecular layer

cellular

abnormal Purkinje cell mitochondrial morphology ( J:132329 )

• ultrastructurally the mitochondria in mutant Purkinje cells shows dramatic defects in mitochondrial morphology, distribution, and cristae organization

abnormal respiratory electron transport chain ( J:132329 )

• ecreased cytochrome C oxidase activity and increased succinate dehydrogenase activity in Purkinje cells of 9-weeks-old mutant mice indicating the electron transport chain dysfunction in mitochondria

Allelic Composition	Mfn2^tm1Dcc/Mfn2^tm3Dcc Tg(EIIa-cre)C5379Lmgd/0
Genetic Background	involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:132329 )

• embryos die during mid-gestation similar to Mfn2^tm1Dcc homozygous embryos

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired righting response ( J:132329 )

• mice surviving beyond P1 cannot easily regain posture when placed on their backs

impaired limb coordination ( J:132329 )

• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body

decreased body size ( J:132329 )

• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

nervous system

small cerebellum ( J:132329 )

• severe defect in postnatal cerebellar growth

mortality/aging

postnatal lethality, complete penetrance ( J:132329 )

• mutant mice that survive the neonatal period die by P17

• mutant pups are born at appropriate Mendelian ratio

neonatal lethality, incomplete penetrance ( J:132329 )

• after birth, about one third of mutant mice die on postnatal day 1

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm1Dcc/Mfn1^tm2Dcc Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (45 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (45 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:132329 )

• invariably die on P0

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Mfn1^tm2Dcc/Mfn1⁺ Mfn2^tm1Dcc/Mfn2^tm3Dcc
Genetic Background	involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Mfn1^tm2Dcc mutation (2 available); any Mfn1 mutation (45 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)
Mfn2^tm3Dcc mutation (2 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:132329 )

• mutant pups are born at appropriate Mendelian ratio

• mutant mice that survive the neonatal period die by P17

neonatal lethality, incomplete penetrance ( J:132329 )

• after birth, about one third of mutant mice die on postnatal day 1

behavior/neurological

impaired righting response ( J:132329 )

• mice surviving beyond P1 cannot easily regain posture when placed on their backs

impaired limb coordination ( J:132329 )

• mice surviving beyond P1 display uncoordinated limb movements, and move primarily by writhing on their abdomen

growth/size/body

decreased body size ( J:132329 )

• mice surviving beyond P1 are severely runted, likely due to feeding problems secondary to their movement disorder

Allelic Composition	Mfn1^tm1Dcc/Mfn1^tm1Dcc Mfn2^tm1Dcc/Mfn2^tm1Dcc
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1^tm1Dcc mutation (0 available); any Mfn1 mutation (45 available)
Mfn2^tm1Dcc mutation (0 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:81438 )

• death occurs earlier than when either allele is singly homozygous

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24