Phenotypes associated with this allele

• Allele Symbol: Foxk1^tm1Djg
• Allele Name: targeted mutation 1, Daniel J Garry
• Allele ID: MGI:2450307
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxk1^tm1Djg/Foxk1^tm1Djg	involves: 129S4/SvJae	MGI:3655082
cx2	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Foxk1^tm1Djg/Foxk1^tm1Djg	involves: 129S2/SvPas * 129S4/SvJae	MGI:3655091
cx3	Dmd^mdx/Dmd^mdx Foxk1^tm1Djg/Foxk1^tm1Djg	involves: 129S4/SvJae * C57BL/10ScSn	MGI:3655088
cx4	Dmd^mdx/Y Foxk1^tm1Djg/Foxk1^tm1Djg	involves: 129S4/SvJae * C57BL/10ScSn	MGI:3655090
cx5	Dmd^mdx/Dmd^+ Foxk1^tm1Djg/Foxk1^+	involves: 129S4/SvJae * C57BL/10ScSn	MGI:3655093

Genotype
MGI:3655082

hm1

• Allelic Composition: Foxk1^tm1Djg/Foxk1^tm1Djg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:62225 )

• year old mice are 60% the size of age matched controls

muscle

abnormal myogenesis ( J:81688 )

abnormal muscle precursor cell morphology ( J:81688 )

• pool of myogenic progenitor cells in skeletal muscle is reduced by 71%

impaired skeletal muscle regeneration ( J:62225 )

• repair of skeletal muscle damaged by cardiotoxin injection is impaired

• eventual regeneration is accompanied by extensive replacement of muscle with fat

cellular

abnormal cell cycle ( J:81688 )

• cell cycle progression is disrupted

• increased numbers of G₀ and G₁ cells

• decreased numbers of S and G₂/M cells

Genotype
MGI:3655091

cx2

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj; Foxk1^tm1Djg/Foxk1^tm1Djg
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

cellular

cellular phenotype ( J:81688 )

N • G₀/G₁ arrest of cell cycle is prevented

growth/size/body

growth/size/body region phenotype ( J:81688 )

N • growth retardation is prevented

N • there is no significant size difference from controls

muscle

muscle phenotype ( J:81688 )

N • no impairment in skeletal muscle regeneration is observed

Genotype
MGI:3655088

cx3

• Allelic Composition: Dmd^mdx/Dmd^mdx; Foxk1^tm1Djg/Foxk1^tm1Djg
• Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

mortality/aging

premature death ( J:62225 )

♀ • all are dead by 3 months of age

postnatal lethality, incomplete penetrance ( J:62225 )

♀ • die within a few weeks of birth

♀ • few survive beyond weaning

behavior/neurological

weakness ( J:62225 )

♀ • fragile and weak

decreased locomotor activity ( J:62225 )

♀

muscle

skeletal muscle fibrosis ( J:62225 )

♀ • fibrosis in muscles of the chest wall, the diaphragm and the intercostals

skeletal muscle necrosis ( J:62225 )

♀

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:62225

Genotype
MGI:3655090

cx4

• Allelic Composition: Dmd^mdx/Y; Foxk1^tm1Djg/Foxk1^tm1Djg
• Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

mortality/aging

premature death ( J:62225 )

♂ • all are dead by 3 months of age

postnatal lethality, incomplete penetrance ( J:62225 )

♂ • die within a few weeks of birth

♂ • few survive beyond weaning

behavior/neurological

weakness ( J:62225 )

♂ • fragile and weak

decreased locomotor activity ( J:62225 )

♂

muscle

skeletal muscle fibrosis ( J:62225 )

♂ • fibrosis in muscles of the chest wall, the diaphragm and the intercostals

skeletal muscle necrosis ( J:62225 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:62225

Genotype
MGI:3655093

cx5

• Allelic Composition: Dmd^mdx/Dmd⁺; Foxk1^tm1Djg/Foxk1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/10ScSn

growth/size/body

decreased body size ( J:62225 )

♀ • mice survive to adulthood but remain small in size

muscle

skeletal muscle necrosis ( J:62225 )

♀ • extensive muscle necrosis is observed up to 6 months of age