Phenotypes associated with this allele

• Allele Symbol: Tg(Tek-cre/ERT2)1Arnd
• Allele Name: transgene insertion 1, Bernd Arnold
• Allele ID: MGI:2450312
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wt1^tm1.1Ndha/Wt1^tm1.1Ndha Tg(Tek-cre/ERT2)1Arnd/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5824303
cn2	Braf^tm1Sva/Braf^tm1Sva Tg(Tek-cre/ERT2)1Arnd/0	involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ	MGI:3622482
cn3	Rgs2^tm1.1Kjb/Rgs2^tm1.1Kjb Tg(Tek-cre/ERT2)1Arnd/?	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:5426418
cn4	Gja5^tm1Mchn/Gja5^tm1Mchn Tg(Tek-cre/ERT2)1Arnd/0	involves: C57BL/6 * DBA/2	MGI:4818413

Genotype
MGI:5824303

cn1

• Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1.1Ndha; Tg(Tek-cre/ERT2)1Arnd/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal coronary vessel morphology ( J:229936 )

• embryos from pregnant females injected with tamoxifen at E10 show a reduction in the number of coronary vessels, especially transmural vessels connecting endocardial and epicardial elements of the coronary vasculature

• however, mice injected with tamoxifen at E10 show normal heart morphology

Genotype
MGI:3622482

cn2

• Allelic Composition: Braf^tm1Sva/Braf^tm1Sva; Tg(Tek-cre/ERT2)1Arnd/0
• Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

normal phenotype

no abnormal phenotype detected ( J:105998 )

Genotype
MGI:5426418

cn3

• Allelic Composition: Rgs2^tm1.1Kjb/Rgs2^tm1.1Kjb; Tg(Tek-cre/ERT2)1Arnd/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

cardiovascular system

cardiovascular system phenotype ( J:184284 )

N • phenylephrine constriction in mesenteric arteries after tamoxifen treatment is normal

N • daytime arterial pressure is normal 1 week after tamoxifen treatment

N • heart rate is normal

increased mean systemic arterial blood pressure ( J:184284 )

• dark phase pressure is increased somewhat by 9 days after tamoxifen treatment

decreased vasodilation ( J:184284 )

• vasodilation due to acetyl choline in mesenteric arteries after tamoxifen treatment is dramatically reduced

• sodium nitroprusside induced vasodilation after tamoxifen treatment is similar to controls

• luminal application of pertussis toxin restores acetyl choline vasodilation in mesenteric arteries

muscle

decreased vasodilation ( J:184284 )

• vasodilation due to acetyl choline in mesenteric arteries after tamoxifen treatment is dramatically reduced

• sodium nitroprusside induced vasodilation after tamoxifen treatment is similar to controls

• luminal application of pertussis toxin restores acetyl choline vasodilation in mesenteric arteries

Genotype
MGI:4818413

cn4

• Allelic Composition: Gja5^tm1Mchn/Gja5^tm1Mchn; Tg(Tek-cre/ERT2)1Arnd/0
• Genetic Background: involves: C57BL/6 * DBA/2

homeostasis/metabolism

increased susceptibility to injury ( J:161949 )

• tamoxifen treated mice subjected to femoral artery occlusion exhibit reduced hindlimb perfusion compared with similarly treated wild-type mice