renal/urinary system
• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice
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• mice treated with streptozocin and fed a high-fat diet to induce diabetes fail to compared with similarly treated mice
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• mice treated with adriamycin to induce nephropathy exhibit lower urinary albumin excretion compared with similarly treated wild-type mice
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• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice
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• mice treated with adriamycin to induce nephropathy exhibit less glomerulosclerosis compared with similarly treated wild-type mice
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• in mice treated with streptozocin and fed a high-fat diet
• however, accumulation in the tubules is comparable to similarly treated wild-type mice
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homeostasis/metabolism
• mice treated with streptozocin and fed a high-fat diet to induce diabetes fail to compared with similarly treated mice
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• mice treated with adriamycin to induce nephropathy exhibit lower urinary albumin excretion compared with similarly treated wild-type mice
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• mice treated with streptozocin and fed a high-fat diet to induce diabetes exhibit decreased urine albumin level and less glomerular and podocyte injuries with reduced podocyte loss and apoptosis compared with similarly treated wild-type mice
• mice treated with adriamycin to induce nephropathy exhibit reduced injury (lower urinary albumin excretion and less glomerulosclerosis) compared with similarly treated wild-type mice
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cellular
• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice
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