nervous system
• the inner mesaxon appears disorganized
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• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves
• abnormal folding increases with age
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• hypomyelination of the ventral roots that is more severe than in single conditional null Dag1tm2Kcam mice
• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination
• macrophages are more numerous in double mutants compared to single conditional null Dag1tm2Kcam mice
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• slight but non significant reduction compared to single conditional null Dag1tm2Kcam mice
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• slight but non significant increase compared to single conditional null Dag1tm2Kcam mice
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• slight but non significant reduction compared to single conditional null Dag1tm2Kcam mice
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