About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mpz-cre)26Mes
transgene insertion 26, Albee Messing
MGI:2450448
Summary 23 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dag1tm2Kcam/Dag1tm2Kcam
Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6 * FVB/N MGI:3804181
cn2
Dag1tm2Kcam/Dag1tm2Kcam
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6 * FVB/N MGI:3804182
cn3
Itga3tm1Hap/Itga3tm1Hap
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6 * FVB/NTac MGI:5563094
cn4
Itga3tm1Hap/Itga3tm1Hap
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6 * FVB/NTac MGI:5563095
cn5
Sirt2tm1.1Auw/Sirt2tm1.1Auw
Tg(Mpz-cre)26Mes/0
involves: 129 * C57BL/6J * FVB/N MGI:5295752
cn6
Lamc1tm1Strl/Lamc1tm1Strl
Tg(Mpz-cre)26Mes/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:2683489
cn7
Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5558043
cn8
Dlg1tm1Rlh/Dlg1tm1.1Rlh
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5558044
cn9
Itga6tm2Egl/Itga6tm2Egl
Itga7tm1Umr/Itga7tm1Umr
Tg(Mpz-cre)26Mes/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac MGI:5563096
cn10
Itgb4tm1Mfel/Itgb4tm1.1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * C57BL/6 * FVB/N MGI:3804180
cn11
Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * C57BL/6 * FVB/N MGI:3804179
cn12
Mtmr2tm1Abol/Mtmr2tm1Abol
Tg(Mpz-cre)26Mes/0
involves: 129S2/SvPas * FVB/N MGI:3513669
cn13
Col1a1tm1(CAG-Sirt2)Jmi/Col1a1+
Tg(Mpz-cre)26Mes/0
involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5295750
cn14
Resttm1.1Yasu/Rest+
Tg(Mpz-cre)26Mes/0
involves: 129S4/SvJae * C57BL/6 * FVB/NTac MGI:6241492
cn15
Resttm1.1Yasu/Resttm1.1Yasu
Tg(Mpz-cre)26Mes/0
involves: 129S4/SvJae * C57BL/6 * FVB/NTac MGI:6241493
cn16
Pi4kbtm1.1Tbal/Pi4kbtm1.1Tbal
Tg(Mpz-cre)26Mes/0
involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:6696059
cn17
Lpin1tm1Rchr/Lpin1tm1Rchr
Tg(Mpz-cre)26Mes/0
involves: 129S6/SvEvTac * FVB/N MGI:3800405
cn18
Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac MGI:6467549
cn19
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
involves: C57BL/6 * FVB/NTac MGI:5563093
cn20
Dnm2tm1Ueli/Dnm2tm2.1Ics
Tg(Mpz-cre)26Mes/0
involves: C57BL/6J * C57BL/6N * FVB/NTac MGI:6506449
cn21
Cyth2tm1c(EUCOMM)Wtsi/Cyth2tm1c(EUCOMM)Wtsi
Tg(Mpz-cre)26Mes/0
involves: C57BL/6N * FVB/NTac MGI:6151124
cn22
Nfasctm1Bhat/Nfasctm1Bhat
Tg(Mpz-cre)26Mes/?
involves: FVB/N MGI:3836431
cn23
Gdap1tm1Ics/Gdap1tm1Ics
Tg(Mpz-cre)26Mes/0
involves: FVB/NTac MGI:5789297


Genotype
MGI:3804181
cn1
Allelic
Composition
Dag1tm2Kcam/Dag1tm2Kcam
Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm2Kcam mutation (2 available); any Dag1 mutation (109 available)
Itgb4tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the inner mesaxon appears disorganized
• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves
• abnormal folding increases with age
• hypomyelination of the ventral roots that is more severe than in single conditional null Dag1tm2Kcam mice
• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination
• macrophages are more numerous in double mutants compared to single conditional null Dag1tm2Kcam mice
• slight but non significant reduction compared to single conditional null Dag1tm2Kcam mice
• slight but non significant increase compared to single conditional null Dag1tm2Kcam mice
• slight but non significant reduction compared to single conditional null Dag1tm2Kcam mice




Genotype
MGI:3804182
cn2
Allelic
Composition
Dag1tm2Kcam/Dag1tm2Kcam
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm2Kcam mutation (2 available); any Dag1 mutation (109 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves
• hypomyelination of the ventral roots
• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination
• reduced motor action potential amplitude




Genotype
MGI:5563094
cn3
Allelic
Composition
Itga3tm1Hap/Itga3tm1Hap
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Hap mutation (0 available); any Itga3 mutation (53 available)
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination




Genotype
MGI:5563095
cn4
Allelic
Composition
Itga3tm1Hap/Itga3tm1Hap
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Hap mutation (0 available); any Itga3 mutation (53 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination




Genotype
MGI:5295752
cn5
Allelic
Composition
Sirt2tm1.1Auw/Sirt2tm1.1Auw
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2tm1.1Auw mutation (1 available); any Sirt2 mutation (27 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Sirt2tm1.1Auw/Sirt2tm1.1Auw Tg(Mpz-cre)26Mes/0 mice display hypomyelination

nervous system
• mice exhibit a transient delay in myelination compared with wild-type mice
• the sciatic nerve is hypomyelinated at P1, P3, and P5
• at P21 and P28, mice exhibit extensive outfoldings in compact myelin located in close vicinity to the paranode
• following nerve crush injury, mice exhibit reduced myelination compared with wild-type mice
• however, mice exhibit normal myelination at P7 and remyelination following nerve crush injury after 28 days

homeostasis/metabolism
• remyelination following nerve crush injury is delayed compared to in wild-type mice
• however, axon regeneration is normal

behavior/neurological
N
• mice exhibit normal function on a rotarod, grip strength, and thermal nociception




Genotype
MGI:2683489
cn6
Allelic
Composition
Lamc1tm1Strl/Lamc1tm1Strl
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1tm1Strl mutation (1 available); any Lamc1 mutation (143 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons
• mutant sciatic nerves are undermyelinated even though many Schwann cells are present
• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

behavior/neurological




Genotype
MGI:5558043
cn7
Allelic
Composition
Dlg1tm1Rlh/Dlg1tm1Rlh
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (76 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at P10, P20 and P45
• however, myelination is normal at P90 and 6 months




Genotype
MGI:5558044
cn8
Allelic
Composition
Dlg1tm1Rlh/Dlg1tm1.1Rlh
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1.1Rlh mutation (0 available); any Dlg1 mutation (76 available)
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (76 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal myelination at P90




Genotype
MGI:5563096
cn9
Allelic
Composition
Itga6tm2Egl/Itga6tm2Egl
Itga7tm1Umr/Itga7tm1Umr
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Itga7tm1Umr mutation (0 available); any Itga7 mutation (35 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• delay in radial sorting of axons in the sciatic nerve at P5
• arrest in radial sorting, with axon bundles containing naked, mixed caliber axons
• arrest in radial sorting, with axon bundles containing mixed caliber axons lacking ensheathing Schwann cells and having redundant and detached basal lamina
• cells spread less when plated on laminin compared to wild-type cells
• bundles of naked axons are seen at P15 and P28 in the sciatic nerve




Genotype
MGI:3804180
cn10
Allelic
Composition
Itgb4tm1Mfel/Itgb4tm1.1Mfel
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm1.1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Itgb4tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological
N
• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected




Genotype
MGI:3804179
cn11
Allelic
Composition
Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological
N
• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected




Genotype
MGI:3513669
cn12
Allelic
Composition
Mtmr2tm1Abol/Mtmr2tm1Abol
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtmr2tm1Abol mutation (0 available); any Mtmr2 mutation (38 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• sciatic nerves had myelin outfoldings and recurrent loops in similar numbers and location as Mtmr2tm1.1Abol null mice
• sciatic nerves had myelin outfoldings and recurrent loops in similar numbers and location as Mtmr2tm1.1Abol null mice




Genotype
MGI:5295750
cn13
Allelic
Composition
Col1a1tm1(CAG-Sirt2)Jmi/Col1a1+
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(CAG-Sirt2)Jmi mutation (1 available); any Col1a1 mutation (163 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Delayed remyelination after nerve crush injury in Col1a1tm1(CAG-Sirt2)Jmi/Col1a1tm1(CAG-Sirt2)Jmi Tg(Mpz-cre)26Mes/0 mice

homeostasis/metabolism
• remyelination following nerve crush injury is delayed compared to in wild-type mice
• however, axon regeneration is normal

nervous system
• remyelination following nerve crush injury is delayed compared to in wild-type mice




Genotype
MGI:6241492
cn14
Allelic
Composition
Resttm1.1Yasu/Rest+
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice never form white spots including on the belly region




Genotype
MGI:6241493
cn15
Allelic
Composition
Resttm1.1Yasu/Resttm1.1Yasu
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice never form white spots including on the belly region




Genotype
MGI:6696059
cn16
Allelic
Composition
Pi4kbtm1.1Tbal/Pi4kbtm1.1Tbal
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi4kbtm1.1Tbal mutation (0 available); any Pi4kb mutation (40 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction to almost complete lack of caveolae, missing or severely underdeveloped Schwann cell microvilli, and disorganized Golgi
• in small diameter axons
• disorganization of the Node of Ranvier
• disintegration of basal lamina around the Remak bundles
• missing or severely underdeveloped Schwann cell microvilli allowing for axon herniation
• more nuclei and deduced total lipid content with reduced sphingomyelin and phosphatidylethanolamine

behavior/neurological
• small impairment
• noticeable at 3 weeks after birth
• in hindlimb




Genotype
MGI:3800405
cn17
Allelic
Composition
Lpin1tm1Rchr/Lpin1tm1Rchr
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpin1tm1Rchr mutation (0 available); any Lpin1 mutation (57 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells
• accumulation of lipid-containing particles in the perineurial and endoneurial compartments
• however, unlike Lpin1fld homozygotes no reduction is seen in the number of adipocytes in the epineurium
• strong demyelination of the sciatic nerve similar to Lpin1fld homozygotes
• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells
• reduced motor nerve conduction velocity is accompanied by temporal dispersion and reduction of compound muscle action potentials
• strong reduction in motor nerve conduction velocity of the sciatic nerve at P56

behavior/neurological
• clench toes of the hind feet when lifted by the tail
• develops by 2 weeks of age




Genotype
MGI:6467549
cn18
Allelic
Composition
Rab35tm1.1Vha/Rab35tm1.1Vha
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35tm1.1Vha mutation (0 available); any Rab35 mutation (21 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• born at normal Mendelian ratio

nervous system
• normal thickness in sciatic nerves and normal number of myelinated axons at age P20, P30 and P90
• reduced thickness in larger sciatic nerves (>5 micrometer diameter) at age P90
• in sciatic nerves at age P90




Genotype
MGI:5563093
cn19
Allelic
Composition
Itga6tm2Egl/Itga6tm2Egl
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable

nervous system
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• occasional
• cells spread less when plated on laminin compared to wild-type cells
• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon




Genotype
MGI:6506449
cn20
Allelic
Composition
Dnm2tm1Ueli/Dnm2tm2.1Ics
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2tm1Ueli mutation (0 available); any Dnm2 mutation (100 available)
Dnm2tm2.1Ics mutation (0 available); any Dnm2 mutation (100 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show severe demyelinating neuropathy
• nerves show a strong reduction of myelinated axons at P24, with an increase in the number of sorted myelin-competent axons that are not enwrapped by myelin
• cells with engulfed myelin inclusions, indicative of ongoing demyelination, are commonly seen in nerves at P24
• however, the number of sorted axons and numbers of structural myelin aberrations are not changed
• no morphological changes are seen in tibial nerves or sciatic nerves at P5, indicating normal radial axonal sorting and correct onset of myelination
• electrophysiology shows decreased compound muscle action potential amplitude at P24
• electrophysiology shows reduced motor nerve conduction velocity at P24
• compound sensory nerve conduction velocity and compound sensory amplitude are not detectible in P24 mice




Genotype
MGI:6151124
cn21
Allelic
Composition
Cyth2tm1c(EUCOMM)Wtsi/Cyth2tm1c(EUCOMM)Wtsi
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: C57BL/6N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyth2tm1c(EUCOMM)Wtsi mutation (0 available); any Cyth2 mutation (21 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• sciatic nerve cells exhibit normal proliferation and apoptosis
• reduced myelin thickness in the sciatic nerve of P5 mice




Genotype
MGI:3836431
cn22
Allelic
Composition
Nfasctm1Bhat/Nfasctm1Bhat
Tg(Mpz-cre)26Mes/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasctm1Bhat mutation (0 available); any Nfasc mutation (61 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• abnormal neurological defects do not appear until 90 days of age

nervous system
• conduction velocity of tibial/plantar nerves is reduced about 50%




Genotype
MGI:5789297
cn23
Allelic
Composition
Gdap1tm1Ics/Gdap1tm1Ics
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdap1tm1Ics mutation (0 available); any Gdap1 mutation (23 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hypomyelination of the plantar nerve in 19 month old mice with no axonal loss

cellular
N
• axonal area covered by mitochondria in axons of plantar nerves is similar to wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory