All Phenotypes Tg(Mpz-cre)26Mes MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mpz-cre)26Mes
transgene insertion 26, Albee Messing
MGI:2450448

Summary

23 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dag1^tm2Kcam/Dag1^tm2Kcam Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804181
cn2	Dag1^tm2Kcam/Dag1^tm2Kcam Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804182
cn3	Itga3^tm1Hap/Itga3^tm1Hap Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6 * FVB/NTac	MGI:5563094
cn4	Itga3^tm1Hap/Itga3^tm1Hap Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6 * FVB/NTac	MGI:5563095
cn5	Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6J * FVB/N	MGI:5295752
cn6	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:2683489
cn7	Dlg1^tm1Rlh/Dlg1^tm1Rlh Tg(Mpz-cre)26Mes/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac	MGI:5558043
cn8	Dlg1^tm1Rlh/Dlg1^tm1.1Rlh Tg(Mpz-cre)26Mes/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac	MGI:5558044
cn9	Itga6^tm2Egl/Itga6^tm2Egl Itga7^tm1Umr/Itga7^tm1Umr Tg(Mpz-cre)26Mes/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac	MGI:5563096
cn10	Itgb4^tm1Mfel/Itgb4^tm1.1Mfel Tg(Mpz-cre)26Mes/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3804180
cn11	Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3804179
cn12	Mtmr2^tm1Abol/Mtmr2^tm1Abol Tg(Mpz-cre)26Mes/0	involves: 129S2/SvPas * FVB/N	MGI:3513669
cn13	Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1⁺ Tg(Mpz-cre)26Mes/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5295750
cn14	Rest^tm1.1Yasu/Rest⁺ Tg(Mpz-cre)26Mes/0	involves: 129S4/SvJae * C57BL/6 * FVB/NTac	MGI:6241492
cn15	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(Mpz-cre)26Mes/0	involves: 129S4/SvJae * C57BL/6 * FVB/NTac	MGI:6241493
cn16	Pi4kb^tm1.1Tbal/Pi4kb^tm1.1Tbal Tg(Mpz-cre)26Mes/0	involves: 129S6/SvEvTac * C57BL/6 * FVB	MGI:6696059
cn17	Lpin1^tm1Rchr/Lpin1^tm1Rchr Tg(Mpz-cre)26Mes/0	involves: 129S6/SvEvTac * FVB/N	MGI:3800405
cn18	Rab35^tm1.1Vha/Rab35^tm1.1Vha Tg(Mpz-cre)26Mes/0	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac	MGI:6467549
cn19	Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0	involves: C57BL/6 * FVB/NTac	MGI:5563093
cn20	Dnm2^tm1Ueli/Dnm2^tm2.1Ics Tg(Mpz-cre)26Mes/0	involves: C57BL/6J * C57BL/6N * FVB/NTac	MGI:6506449
cn21	Cyth2^{tm1c(EUCOMM)Wtsi}/Cyth2^{tm1c(EUCOMM)Wtsi} Tg(Mpz-cre)26Mes/0	involves: C57BL/6N * FVB/NTac	MGI:6151124
cn22	Nfasc^tm1Bhat/Nfasc^tm1Bhat Tg(Mpz-cre)26Mes/?	involves: FVB/N	MGI:3836431
cn23	Gdap1^tm1Ics/Gdap1^tm1Ics Tg(Mpz-cre)26Mes/0	involves: FVB/NTac	MGI:5789297

Allelic Composition	Dag1^tm2Kcam/Dag1^tm2Kcam Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1^tm2Kcam mutation (2 available); any Dag1 mutation (109 available)
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:137852 )

• the inner mesaxon appears disorganized

abnormal myelin sheath morphology ( J:137852 )

• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves

• abnormal folding increases with age

demyelination ( J:137852 )

• hypomyelination of the ventral roots that is more severe than in single conditional null Dag1^tm2Kcam mice

• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination

• macrophages are more numerous in double mutants compared to single conditional null Dag1^tm2Kcam mice

abnormal action potential ( J:137852 )

• slight but non significant reduction compared to single conditional null Dag1^tm2Kcam mice

abnormal nerve conduction ( J:137852 )

• slight but non significant increase compared to single conditional null Dag1^tm2Kcam mice

decreased nerve conduction velocity ( J:137852 )

• slight but non significant reduction compared to single conditional null Dag1^tm2Kcam mice

Allelic Composition	Dag1^tm2Kcam/Dag1^tm2Kcam Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1^tm2Kcam mutation (2 available); any Dag1 mutation (109 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves

demyelination ( J:137852 )

• hypomyelination of the ventral roots

• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination

abnormal action potential ( J:137852 )

• reduced motor action potential amplitude

abnormal nerve conduction ( J:137852 )

decreased nerve conduction velocity ( J:137852 )

Allelic Composition	Itga3^tm1Hap/Itga3^tm1Hap Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3^tm1Hap mutation (0 available); any Itga3 mutation (53 available)
Itga6^tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:204174 )

N	• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination

Allelic Composition	Itga3^tm1Hap/Itga3^tm1Hap Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3^tm1Hap mutation (0 available); any Itga3 mutation (53 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:204174 )

N	• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination

Allelic Composition	Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2^tm1.1Auw mutation (1 available); any Sirt2 mutation (27 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0 mice display hypomyelination

nervous system

abnormal myelination ( J:177468 )

• mice exhibit a transient delay in myelination compared with wild-type mice

• the sciatic nerve is hypomyelinated at P1, P3, and P5

• at P21 and P28, mice exhibit extensive outfoldings in compact myelin located in close vicinity to the paranode

• following nerve crush injury, mice exhibit reduced myelination compared with wild-type mice

• however, mice exhibit normal myelination at P7 and remyelination following nerve crush injury after 28 days

decreased nerve conduction velocity ( J:177468 )

• at P21 and P28

homeostasis/metabolism

abnormal response to injury ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

• however, axon regeneration is normal

behavior/neurological

behavior/neurological phenotype ( J:177468 )

N	• mice exhibit normal function on a rotarod, grip strength, and thermal nociception

Allelic Composition	Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lamc1^tm1Strl mutation (1 available); any Lamc1 mutation (143 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon radial sorting ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

abnormal sciatic nerve morphology ( J:86714 )

• mutant sciatic nerves are undermyelinated even though many Schwann cells are present

abnormal myelination ( J:86714 )

• in mutant nerves, Schwann cells populate the nerve but fail to sort and myelinate axons

behavior/neurological

tremors ( J:86714 )

forelimb paralysis ( J:86714 )

Allelic Composition	Dlg1^tm1Rlh/Dlg1^tm1Rlh Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1^tm1Rlh mutation (1 available); any Dlg1 mutation (76 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hypermyelination ( J:202688 )

• at P10, P20 and P45

• however, myelination is normal at P90 and 6 months

Allelic Composition	Dlg1^tm1Rlh/Dlg1^tm1.1Rlh Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1^tm1.1Rlh mutation (0 available); any Dlg1 mutation (76 available)
Dlg1^tm1Rlh mutation (1 available); any Dlg1 mutation (76 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:202688 )

N	• mice exhibit normal myelination at P90

Allelic Composition	Itga6^tm2Egl/Itga6^tm2Egl Itga7^tm1Umr/Itga7^tm1Umr Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6^tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Itga7^tm1Umr mutation (0 available); any Itga7 mutation (35 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon radial sorting ( J:204174 )

• delay in radial sorting of axons in the sciatic nerve at P5

• arrest in radial sorting, with axon bundles containing naked, mixed caliber axons

abnormal sciatic nerve morphology ( J:204174 )

• arrest in radial sorting, with axon bundles containing mixed caliber axons lacking ensheathing Schwann cells and having redundant and detached basal lamina

axon degeneration ( J:204174 )

abnormal Schwann cell physiology ( J:204174 )

• cells spread less when plated on laminin compared to wild-type cells

abnormal myelination ( J:204174 )

• bundles of naked axons are seen at P15 and P28 in the sciatic nerve

hypermyelination ( J:204174 )

Allelic Composition	Itgb4^tm1Mfel/Itgb4^tm1.1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4^tm1.1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological

behavior/neurological phenotype ( J:137852 )

N	• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected

Allelic Composition	Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological

behavior/neurological phenotype ( J:137852 )

N	• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected

Allelic Composition	Mtmr2^tm1Abol/Mtmr2^tm1Abol Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtmr2^tm1Abol mutation (0 available); any Mtmr2 mutation (38 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal sciatic nerve morphology ( J:94373 )

• sciatic nerves had myelin outfoldings and recurrent loops in similar numbers and location as Mtmr2^tm1.1Abol null mice

abnormal myelination ( J:94373 )

• sciatic nerves had myelin outfoldings and recurrent loops in similar numbers and location as Mtmr2^tm1.1Abol null mice

Allelic Composition	Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1⁺ Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(CAG-Sirt2)Jmi} mutation (1 available); any Col1a1 mutation (163 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Delayed remyelination after nerve crush injury in Col1a1^{tm1(CAG-Sirt2)Jmi}/Col1a1^{tm1(CAG-Sirt2)Jmi} Tg(Mpz-cre)26Mes/0 mice

homeostasis/metabolism

abnormal response to injury ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

• however, axon regeneration is normal

nervous system

abnormal myelination ( J:177468 )

• remyelination following nerve crush injury is delayed compared to in wild-type mice

Allelic Composition	Rest^tm1.1Yasu/Rest⁺ Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:230341 )

N	• mice never form white spots including on the belly region

Allelic Composition	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rest^tm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:230341 )

N	• mice never form white spots including on the belly region

Allelic Composition	Pi4kb^tm1.1Tbal/Pi4kb^tm1.1Tbal Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi4kb^tm1.1Tbal mutation (0 available); any Pi4kb mutation (40 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Schwann cell morphology ( J:297534 )

• reduction to almost complete lack of caveolae, missing or severely underdeveloped Schwann cell microvilli, and disorganized Golgi

decreased myelin sheath amount ( J:297534 )

• in small diameter axons

abnormal node of Ranvier morphology ( J:297534 )

• disorganization of the Node of Ranvier

• missing or severely underdeveloped Schwann cell microvilli allowing for axon herniation

• disintegration of basal lamina around the Remak bundles

abnormal sciatic nerve morphology ( J:297534 )

• more nuclei and deduced total lipid content with reduced sphingomyelin and phosphatidylethanolamine

decreased nerve conduction velocity ( J:297534 )

behavior/neurological

limb grasping ( J:297534 )

impaired coordination ( J:297534 )

• small impairment

abnormal gait ( J:297534 )

• noticeable at 3 weeks after birth

spasticity ( J:297534 )

• in hindlimb

Allelic Composition	Lpin1^tm1Rchr/Lpin1^tm1Rchr Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpin1^tm1Rchr mutation (0 available); any Lpin1 mutation (57 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Schwann cell morphology ( J:137213 )

• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells

abnormal sciatic nerve morphology ( J:137213 )

• accumulation of lipid-containing particles in the perineurial and endoneurial compartments

• however, unlike Lpin1^fld homozygotes no reduction is seen in the number of adipocytes in the epineurium

demyelination ( J:137213 )

• strong demyelination of the sciatic nerve similar to Lpin1^fld homozygotes

• accumulation of myelin debris in Schwann cells, increase in the number of mast cells and defects in unmyelinated Schwann cells

abnormal nervous system electrophysiology ( J:137213 )

abnormal action potential ( J:137213 )

• reduced motor nerve conduction velocity is accompanied by temporal dispersion and reduction of compound muscle action potentials

decreased nerve conduction velocity ( J:137213 )

• strong reduction in motor nerve conduction velocity of the sciatic nerve at P56

behavior/neurological

limb grasping ( J:137213 )

• clench toes of the hind feet when lifted by the tail

abnormal gait ( J:137213 )

• develops by 2 weeks of age

Allelic Composition	Rab35^tm1.1Vha/Rab35^tm1.1Vha Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab35^tm1.1Vha mutation (0 available); any Rab35 mutation (21 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:294178 )

N	• born at normal Mendelian ratio

nervous system

decreased myelin sheath thickness ( J:294178 )

• normal thickness in sciatic nerves and normal number of myelinated axons at age P20, P30 and P90

• reduced thickness in larger sciatic nerves (>5 micrometer diameter) at age P90

tomacula ( J:294178 )

• in sciatic nerves at age P90

Allelic Composition	Itga6^tm2Egl/Itga6^tm2Egl Tg(Mpz-cre)26Mes/0
Genetic Background	involves: C57BL/6 * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga6^tm2Egl mutation (0 available); any Itga6 mutation (211 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:204174 )

• viable

nervous system

abnormal axon morphology ( J:204174 )

decreased myelin sheath thickness ( J:204174 )

• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon

increased myelin sheath thickness ( J:204174 )

• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon

abnormal sciatic nerve morphology ( J:204174 )

• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons

• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination

• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated

• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon

axon degeneration ( J:204174 )

• occasional

abnormal Schwann cell physiology ( J:204174 )

• cells spread less when plated on laminin compared to wild-type cells

abnormal myelination ( J:204174 )

• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons

• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination

• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated

• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon

hypermyelination ( J:204174 )

• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon

Allelic Composition	Dnm2^tm1Ueli/Dnm2^tm2.1Ics Tg(Mpz-cre)26Mes/0
Genetic Background	involves: C57BL/6J * C57BL/6N * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2^tm1Ueli mutation (0 available); any Dnm2 mutation (100 available)
Dnm2^tm2.1Ics mutation (0 available); any Dnm2 mutation (100 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

demyelination ( J:288372 )

• mice show severe demyelinating neuropathy

• nerves show a strong reduction of myelinated axons at P24, with an increase in the number of sorted myelin-competent axons that are not enwrapped by myelin

• cells with engulfed myelin inclusions, indicative of ongoing demyelination, are commonly seen in nerves at P24

• however, the number of sorted axons and numbers of structural myelin aberrations are not changed

• no morphological changes are seen in tibial nerves or sciatic nerves at P5, indicating normal radial axonal sorting and correct onset of myelination

abnormal action potential ( J:288372 )

• electrophysiology shows decreased compound muscle action potential amplitude at P24

decreased nerve conduction velocity ( J:288372 )

• electrophysiology shows reduced motor nerve conduction velocity at P24

• compound sensory nerve conduction velocity and compound sensory amplitude are not detectible in P24 mice

Allelic Composition	Cyth2^{tm1c(EUCOMM)Wtsi}/Cyth2^{tm1c(EUCOMM)Wtsi} Tg(Mpz-cre)26Mes/0
Genetic Background	involves: C57BL/6N * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyth2^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Cyth2 mutation (21 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:260347 )

N	• sciatic nerve cells exhibit normal proliferation and apoptosis

dysmyelination ( J:260347 )

• reduced myelin thickness in the sciatic nerve of P5 mice

Allelic Composition	Nfasc^tm1Bhat/Nfasc^tm1Bhat Tg(Mpz-cre)26Mes/?
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfasc^tm1Bhat mutation (0 available); any Nfasc mutation (61 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:145846 )

• abnormal neurological defects do not appear until 90 days of age

nervous system

decreased nerve conduction velocity ( J:145846 )

• conduction velocity of tibial/plantar nerves is reduced about 50%

Allelic Composition	Gdap1^tm1Ics/Gdap1^tm1Ics Tg(Mpz-cre)26Mes/0
Genetic Background	involves: FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdap1^tm1Ics mutation (0 available); any Gdap1 mutation (23 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

dysmyelination ( J:221297 )

• hypomyelination of the plantar nerve in 19 month old mice with no axonal loss

decreased nerve conduction velocity ( J:221297 )

cellular

cellular phenotype ( J:221297 )

N	• axonal area covered by mitochondria in axons of plantar nerves is similar to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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