Phenotypes associated with this allele

• Allele Symbol: Tg(Mbp-cre)9Gvn
• Allele Name: transgene insertion 9, Marco Giovannini
• Allele ID: MGI:2450460
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-RND2)1Jya/0 Tg(Mbp-cre)9Gvn/0	involves: C57BL/6 * C57BL/6J * DBA/2 * FVB/N	MGI:7645366
cn2	Rnd2^tm1.1Jya/Rnd2^tm1.1Jya Tg(Mbp-cre)9Gvn/0	involves: C57BL/6 * FVB/N	MGI:7645354

Genotype
MGI:7645366

cn1

• Allelic Composition: Tg(CAG-RND2)1Jya/0; Tg(Mbp-cre)9Gvn/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased myelin sheath thickness ( J:309719 )

• myelin sheath thickness is decreased in 28-day-old mice, with increased average g-ratios

increased myelin sheath thickness ( J:309719 )

• myelin sheath thickness is increased in 14-day old mice, with reduced average g-ratios

abnormal myelination ( J:309719 )

• corpus callosum shows increased myelin thickness in 14-day-old mice and decreased myelin thickness in 28-day-old mice

• expression levels of the myelin marker proteins MBP and CNPase are increased in 14-day-old mice but are decreased in brain tissues at P28

Genotype
MGI:7645354

cn2

• Allelic Composition: Rnd2^tm1.1Jya/Rnd2^tm1.1Jya; Tg(Mbp-cre)9Gvn/0
• Genetic Background: involves: C57BL/6 * FVB/N

nervous system

decreased myelin sheath thickness ( J:309719 )

• myelin sheaths are thinner in 15-day-old mice, with increased average g-ratios

increased myelin sheath thickness ( J:309719 )

• myelin sheaths are thicker in 28-day-old mice and in 2-month old mice, with reduced average g-ratios, indicating that the increase in myelin thickness persists into adolescence

abnormal myelination ( J:309719 )

• mice show decreased myelin thickness in the corpus callosum at 14 days of age and increased myelin thickness at 28 days of age, indicating positive regulation of myelin in the early myelinating period and negative regulation of myelination in the later period

• mice show decreased MBP staining and decreased MBP and CNPase expression levels at 14 days of age, but increased levels at 28 days of age

• however, the number of oligodendrocytes are unchanged and staining for the astrocyte maker GFAP and neuron maker NeuN are normal