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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pbsn-cre)8113ANg
transgene insertion 8113A, Norman M Greenberg
MGI:2450559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0 		involves: 129S1/Sv * C57BL/6 MGI:2679902


Genotype
MGI:2679902
cn1
Allelic
Composition		 Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Pbsn-cre)8113ANg/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (89 available)
Tg(Pbsn-cre)8113ANg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland tumor incidence ( J:86212 )
• complete penetrance of invasive and diffuse prostate cancer
• disruption of basement membrane and organ infiltration
• tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe

endocrine/exocrine glands
prostate gland epithelial hyperplasia ( J:86212 )
• focal areas of epithelial hyperplasia
• increased proliferation of epithelial cells
enlarged prostate gland ( J:86212 )
• enlargement of prostate, less pronounced than in homozygotes carrying Tg(Pbsn-cre)4Prb
increased prostate gland tumor incidence ( J:86212 )
• complete penetrance of invasive and diffuse prostate cancer
• disruption of basement membrane and organ infiltration
• tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe

reproductive system
prostate gland epithelial hyperplasia ( J:86212 )
• focal areas of epithelial hyperplasia
• increased proliferation of epithelial cells
enlarged prostate gland ( J:86212 )
• enlargement of prostate, less pronounced than in homozygotes carrying Tg(Pbsn-cre)4Prb
increased prostate gland tumor incidence ( J:86212 )
• complete penetrance of invasive and diffuse prostate cancer
• disruption of basement membrane and organ infiltration
• tumors were less diffuse than in homozygotes carrying Tg(Pbsn-cre)4Prb, variably differentiated, and only affected a single lobe




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory