Phenotypes associated with this allele

• Allele Symbol: Ush1g^js-seal
• Allele Name: seal
• Allele ID: MGI:2450561
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ush1g^js-seal/Ush1g^js-seal	involves: C3H/He	MGI:2450587

Genotype
MGI:2450587

hm1

• Allelic Composition: Ush1g^js-seal/Ush1g^js-seal
• Genetic Background: involves: C3H/He

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head tossing ( J:1174 )

hyperactivity ( J:1174 )

circling ( J:1174 )

hearing/vestibular/ear

vestibular hair cell degeneration ( J:1174 )

• almost all hair cells in the saccular maculae were gone by 90 days

• severe loss of hair cells in the utucular maculae by 18 months

abnormal utricular macula morphology ( J:1174 )

• changes in the uticular maculae appeared by one year of age

• cristae ampularis was well preserved

vestibular saccular macula degeneration ( J:1174 )

• progressive degeneration of saccular maculae beginning at day 21

increased or absent threshold for auditory brainstem response ( J:1174 )

• no ABR detectable in mice ranging in ages from 11 to 117 days of age

deafness ( J:1174 )

nervous system

vestibular hair cell degeneration ( J:1174 )

• almost all hair cells in the saccular maculae were gone by 90 days

• severe loss of hair cells in the utucular maculae by 18 months