All Phenotypes Lipg<tm1Tq> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lipg^tm1Tq
targeted mutation 1, Thomas Quertermous
MGI:2450672

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lipg^tm1Tq/Lipg^tm1Tq	B6.129S6-Lipg^tm1Tq	MGI:3785082
hm2	Lipg^tm1Tq/Lipg^tm1Tq	involves: 129S6/SvEvTac	MGI:3785149
hm3	Lipg^tm1Tq/Lipg^tm1Tq	involves: 129S6/SvEvTac * C57BL/6J	MGI:3785087
ht4	Lipg^tm1Tq/Lipg⁺	B6.129S6-Lipg^tm1Tq	MGI:3785083
cx5	Apoe^tm1Unc/Apoe^tm1Unc Lipg^tm1Tq/Lipg^tm1Tq	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:3785086

Allelic Composition	Lipg^tm1Tq/Lipg^tm1Tq
Genetic Background	B6.129S6-Lipg^tm1Tq

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipg^tm1Tq mutation (1 available); any Lipg mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:81821 )

• both male and female mice exhibit an increase in serum cholesterol (69% increase in male mice) compared to wild-type mice

increased circulating HDL cholesterol level ( J:81821 )

• 57% increase in male compared to in wild-type mice

increased circulating phospholipid level ( J:81821 )

• over 50% increase compared to in wild-type mice

Allelic Composition	Lipg^tm1Tq/Lipg^tm1Tq
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipg^tm1Tq mutation (1 available); any Lipg mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating HDL cholesterol level ( J:129942 )

• unlike in wild-type mice, HDL levels are not affected by hepatic proprotein convertase inhibition

cardiovascular system

abnormal vascular endothelial cell physiology ( J:95158 )

• isolated aortic strips exhibit decreased monocyte binding compared to wild-type strips

Allelic Composition	Lipg^tm1Tq/Lipg^tm1Tq
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipg^tm1Tq mutation (1 available); any Lipg mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:93987 )

increased circulating HDL cholesterol level ( J:93987 )

increased circulating phospholipid level ( J:93987 )

increased circulating triglyceride level ( J:93987 )

Allelic Composition	Lipg^tm1Tq/Lipg⁺
Genetic Background	B6.129S6-Lipg^tm1Tq

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lipg^tm1Tq mutation (1 available); any Lipg mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:81821 )

• 25% increase in male but not female mice compared to in wild-type mice

increased circulating phospholipid level ( J:81821 )

• over 30% increase compared to in wild-type mice

increased circulating triglyceride level ( J:81821 )

• in female mice but not male mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Lipg^tm1Tq/Lipg^tm1Tq
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Lipg^tm1Tq mutation (1 available); any Lipg mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:93987 )

• when fed a high fat diet, male mice exhibit a 2-fold increase in serum cholesterol compared to in either single homozygote on either a normal or high fat diet

increased circulating HDL cholesterol level ( J:93987 )

• compared to in Apoe^tm1Unc homozygotes

increased circulating LDL cholesterol level ( J:93987 )

• compared to in wild-type mice

increased circulating VLDL cholesterol level ( J:93987 )

• compared to in wild-type mice

increased circulating phospholipid level ( J:93987 )

increased circulating triglyceride level ( J:93987 )

• in male mice on a high fat diet

cardiovascular system

decreased susceptibility to atherosclerosis ( J:93987 )

• formation of atherosclerotic plaques is attenuated compared to in Apoe^tm1Unc homozygotes

• when fed a normal diet, atherosclerotic lesions are 67% smaller in females and 71% smaller in males compared to in Apoe^tm1Unc homozygotes

• when fed a high fat diet, atherosclerotic lesion formation is attenuated in male mice and lesion size is decreased 24% compared to in Apoe^tm1Unc homozygotes

atherosclerotic lesions ( J:93987 )

• atherosclerotic lesions contain fewer macrophage infiltration than in Apoe^tm1Unc homozygotes

• monocyte/macrophage binding to atherosclerotic lesions in vitro is reduced compared to in Apoe^tm1Unc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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