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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag2tm1Mao
targeted mutation 1, Marjorie A Oettinger
MGI:2450735
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rag2tm1Mao/Rag2tm1Mao involves: 129 * C57BL/6 MGI:3770255
hm2
 		Rag2tm1Mao/Rag2tm1Mao involves: 129S6/SvEvTac * C57BL/6 MGI:2450740
ht3
 		Rag2tm1Fwa/Rag2tm1Mao involves: 129S/SvEv * C57BL/6 MGI:3770256


Genotype
MGI:3770255
hm1
Allelic
Composition		 Rag2tm1Mao/Rag2tm1Mao
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Mao mutation (0 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third
arrested B cell differentiation ( J:81837 )
• development is impaired at the pro-B cell stage
decreased double-negative T cell number ( J:81837 )
• 4-fold decrease in DN cells
abnormal gamma-delta T cell differentiation ( J:81837 )
• 4-fold reduction in the number of gamma-delta T cells in the thymus
arrested T cell differentiation ( J:81837 )
• T cell development is partially blocked at the CD25+ CD44- (DNIII) stage
decreased immature B cell number ( J:81837 )
• one-third reduction in the number of immature B cells found in bone marrow
increased immature B cell number ( J:81837 )
• increase in pro-B cell
decreased mature B cell number ( J:81837 )
• spleen and lymph nodes have half the number of mature B cells as wild-type controls
decreased pre-B cell number ( J:81837 )
• one-third reduction in the number of pre-B cells found in bone marrow

hematopoietic system
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third
arrested B cell differentiation ( J:81837 )
• development is impaired at the pro-B cell stage
decreased double-negative T cell number ( J:81837 )
• 4-fold decrease in DN cells
abnormal gamma-delta T cell differentiation ( J:81837 )
• 4-fold reduction in the number of gamma-delta T cells in the thymus
arrested T cell differentiation ( J:81837 )
• T cell development is partially blocked at the CD25+ CD44- (DNIII) stage
decreased immature B cell number ( J:81837 )
• one-third reduction in the number of immature B cells found in bone marrow
increased immature B cell number ( J:81837 )
• increase in pro-B cell
decreased mature B cell number ( J:81837 )
• spleen and lymph nodes have half the number of mature B cells as wild-type controls
decreased pre-B cell number ( J:81837 )
• one-third reduction in the number of pre-B cells found in bone marrow

endocrine/exocrine glands
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third




Genotype
MGI:2450740
hm2
Allelic
Composition		 Rag2tm1Mao/Rag2tm1Mao
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Mao mutation (0 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:3770256
ht3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Mao
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Rag2tm1Mao mutation (0 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third
arrested B cell differentiation ( J:81837 )
• development is impaired at the pro-B cell stage
decreased double-negative T cell number ( J:81837 )
• 4-fold decrease in DN cells
abnormal gamma-delta T cell differentiation ( J:81837 )
• 4-fold reduction in the number of gamma-delta T cells in the thymus
arrested T cell differentiation ( J:81837 )
• T cell development is partially blocked at the CD25+ CD44- (DNIII) stage
decreased immature B cell number ( J:81837 )
• one-third reduction in the number of immature B cells found in bone marrow
increased immature B cell number ( J:81837 )
• increase in pro-B cell
decreased mature B cell number ( J:81837 )
• spleen and lymph nodes have half the number of mature B cells as wild-type controls
decreased pre-B cell number ( J:81837 )
• one-third reduction in the number of pre-B cells found in bone marrow

hematopoietic system
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third
arrested B cell differentiation ( J:81837 )
• development is impaired at the pro-B cell stage
decreased double-negative T cell number ( J:81837 )
• 4-fold decrease in DN cells
abnormal gamma-delta T cell differentiation ( J:81837 )
• 4-fold reduction in the number of gamma-delta T cells in the thymus
arrested T cell differentiation ( J:81837 )
• T cell development is partially blocked at the CD25+ CD44- (DNIII) stage
decreased immature B cell number ( J:81837 )
• one-third reduction in the number of immature B cells found in bone marrow
increased immature B cell number ( J:81837 )
• increase in pro-B cell
decreased mature B cell number ( J:81837 )
• spleen and lymph nodes have half the number of mature B cells as wild-type controls
decreased pre-B cell number ( J:81837 )
• one-third reduction in the number of pre-B cells found in bone marrow

endocrine/exocrine glands
thymus hypoplasia ( J:81837 )
• thymus cellularity is reduced by a third




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory