Phenotypes associated with this allele

• Allele Symbol: Swap70^tm1Jess
• Allele Name: targeted mutation 1, Rolf Jessberger
• Allele ID: MGI:2450881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Swap70^tm1Jess/Swap70^tm1Jess	involves: 129T2/SvEms * 129X1/SvJ	MGI:3033463

Genotype
MGI:3033463

hm1

• Allelic Composition: Swap70^tm1Jess/Swap70^tm1Jess
• Genetic Background: involves: 129T2/SvEms * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to gamma-irradiation ( J:71160 )

• B cells derived form homozygous mice are 2-3 fold more sensitive to gamma-irradiation than controls

immune system

abnormal class switch recombination ( J:71160 )

• CD40 dependent class switching to IgE isotype is reduced 5-8 fold in homozygous mice

decreased IgE level ( J:71160 )

• reduced IgE levels (6-7 fold lower) in homozygous mice before immunization and 3-4 fold lower after immunization

increased autoantibody level ( J:71160 )

• homozygous mice develop autoantibodies at a higher frequency than controls

hematopoietic system

abnormal class switch recombination ( J:71160 )

• CD40 dependent class switching to IgE isotype is reduced 5-8 fold in homozygous mice

decreased IgE level ( J:71160 )

• reduced IgE levels (6-7 fold lower) in homozygous mice before immunization and 3-4 fold lower after immunization