Phenotypes associated with this allele

• Allele Symbol: Il17ra^tm1Koll
• Allele Name: targeted mutation 1, Jay K Kolls
• Allele ID: MGI:2450882
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17ra^tm1Koll/Il17ra^tm1Koll	involves: 129	MGI:3803175
hm2	Il17ra^tm1Koll/Il17ra^tm1Koll	involves: 129 * C57BL/6	MGI:3043082
cn3	Apc^tm1Tno/Apc^+ Il17ra^tm1Koll/Il17ra^tm1Koll Tg(CDX2-cre)101Erf/0	involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J	MGI:5446625

Genotype
MGI:3803175

hm1

• Allelic Composition: Il17ra^tm1Koll/Il17ra^tm1Koll
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 cell differentiation ( J:158594 )

• IL25 mediated differentiation is impaired in cultured cells

impaired neutrophil recruitment ( J:136279 )

• recruitment of neutrophils into the peritoneum by IL-17A or IL-17B is severely impaired in these mice

decreased interleukin-17 secretion ( J:177650 )

• cells transduced with an Il17re-expressing retroviral vector exhibit reduced IL17A in response to IL17C compared with similarly treated wild-type cells

decreased interleukin-9 secretion ( J:158594 )

• IL25 application to T cells cultured in Th9 inducing conditions fails to induced IL9 secretion as it does in wild-type cells

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:158594 )

• IL25 mediated differentiation is impaired in cultured cells

impaired neutrophil recruitment ( J:136279 )

• recruitment of neutrophils into the peritoneum by IL-17A or IL-17B is severely impaired in these mice

Genotype
MGI:3043082

hm2

• Allelic Composition: Il17ra^tm1Koll/Il17ra^tm1Koll
• Genetic Background: involves: 129 * C57BL/6

homeostasis/metabolism

pulmonary edema ( J:71097 )

• perivascular edema develops in the lungs by 24 hours after infection with K pneumoniae

immune system

abnormal granulocyte differentiation ( J:71097 )

• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae

• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF

• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores

decreased neutrophil cell number ( J:71097 )

• numbers became attenuated by 18 hours after infection

• significantly neutropenic by 48hours after infection

impaired neutrophil recruitment ( J:71097 )

• decreased neutrophil recruitment to the lungs

abnormal interleukin-13 secretion ( J:139080 )

• splenocytes fail to secrete IL-13 when incubated in vitro with IL-25

• splenocytes produce significantly more IL-13 than controls when stimulated with Con A

• there are no significant increases in levels of IL-13 found in the bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 unlike in wild-type mice which have significant increases

abnormal interleukin-5 secretion ( J:139080 )

• there are no significant increases in levels of IL-5 found in the bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 unlike in wild-type mice which have significant increases

decreased inflammatory response ( J:139080 )

• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF

• intranasal administration of IL-25 fails to induce histological signs of inflammation with damage scores being essentially normal while wild-type mice treated in the same way have significantly higher scores

increased susceptibility to infection ( J:71097 )

• significantly reduced survival after infection with Klebsiella pneumoniae

• pulmonary growth of bacteria significantly greater than in controls 24 hours after infection

respiratory system

pulmonary edema ( J:71097 )

• perivascular edema develops in the lungs by 24 hours after infection with K pneumoniae

hematopoietic system

abnormal granulocyte differentiation ( J:71097 )

• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae

• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF

• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores

decreased neutrophil cell number ( J:71097 )

• numbers became attenuated by 18 hours after infection

• significantly neutropenic by 48hours after infection

impaired neutrophil recruitment ( J:71097 )

• decreased neutrophil recruitment to the lungs

cellular

abnormal granulocyte differentiation ( J:71097 )

• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae

• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF

• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores

Genotype
MGI:5446625

cn3

• Allelic Composition: Apc^tm1Tno/Apc⁺; Il17ra^tm1Koll/Il17ra^tm1Koll; Tg(CDX2-cre)101Erf/0
• Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6J * SJL/J

neoplasm

decreased tumor growth/size ( J:189226 )

• reduced colorectal tumor multiplicity and grown compared to in Apc^tm1Tno/Apc⁺ Tg(CDX2-cre)101Erf mice