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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tectm1Welm
targeted mutation 1, Wilfred Ellmeier
MGI:2450883
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tectm1Welm/Tectm1Welm involves: 129P2/OlaHsd * C57BL/6 MGI:3028886
cx2
 		Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm 		involves: 129P2/OlaHsd * C57BL/6 MGI:3028887


Genotype
MGI:3028886
hm1
Allelic
Composition		 Tectm1Welm/Tectm1Welm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectm1Welm mutation (0 available); any Tec mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:86448 )
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP

immune system
immune system phenotype ( J:66080 )
N
• no developmental alterations in T or B cell populations
• number of splenic T and B cells similar to littermate controls
• B cell activation by either anti-IgM Ab or LPS was similar to that of B cells from littermate controls

homeostasis/metabolism
decreased platelet aggregation ( J:86448 )
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP




Genotype
MGI:3028887
cx2
Allelic
Composition		 Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation (1 available); any Btk mutation (21 available)
Tectm1Welm mutation (0 available); any Tec mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell proliferation ( J:66080 )
• failure to respond to IgM
• attenuated response to LPS
abnormal B cell differentiation ( J:66080 )
• partial block at large pre-B cell stage
increased pre-B cell number ( J:66080 )
• accumulation of CD43+ B cell precursors, indicating partial developmental block
abnormal platelet physiology ( J:86448 )
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
decreased platelet aggregation ( J:86448 )
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

immune system
decreased B cell proliferation ( J:66080 )
• failure to respond to IgM
• attenuated response to LPS
abnormal B cell differentiation ( J:66080 )
• partial block at large pre-B cell stage
increased pre-B cell number ( J:66080 )
• accumulation of CD43+ B cell precursors, indicating partial developmental block
abnormal humoral immune response ( J:66080 )
• failure to respond to thymus-independent antigen (TNP-Ficoll)
• failure to respond to thymus-dependent antigen (TNP-KLH adsorbed on aluminum hydroxide)

homeostasis/metabolism
abnormal platelet physiology ( J:86448 )
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
decreased platelet aggregation ( J:86448 )
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

cellular
decreased B cell proliferation ( J:66080 )
• failure to respond to IgM
• attenuated response to LPS

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
X-linked agammaglobulinemia DOID:14179 OMIM:300755
 J:66080




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory