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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mettm4.1Cpo
targeted mutation 4.1, Carola Ponzetta
MGI:2450967
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mettm2Cpo/Mettm4.1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2450971


Genotype
MGI:2450971
ht1
Allelic
Composition		 Mettm2Cpo/Mettm4.1Cpo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm2Cpo mutation (0 available); any Met mutation (83 available)
Mettm4.1Cpo mutation (0 available); any Met mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:81793 )
• impaired motor coordination in thin rod test

nervous system
abnormal neuron differentiation ( J:81793 )
• 25% decrease in granule cell proliferation
reduced cerebellar foliation ( J:81793 )
• reduced or absent fissures in declival sulcus and intercrural fissure
• reduction of secondary and posterolateral fissures
small cerebellum ( J:81793 )
• cerebellar weight reduced by 20%

cellular
abnormal neuron differentiation ( J:81793 )
• 25% decrease in granule cell proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory