renal/urinary system
• increased apoptosis 1 week after treatment with adriamycin
|
• increased foot process effacement 1 day after treatment with adriamycin
|
• smaller glomeruli and glomerular tuft area
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• increased mesangial matrix accumulation
• mesangial expansion 1 day after treatment with adriamycin
|
mesangiolysis
(
J:91522
)
• focal mesangiolysis and lesions 1 day after treatment with adriamycin
|
• increased succeptibility to adriamycin induced kidney damage
• increased glomerular matrix deposition and hyalinosis by 1 week after treatment with adriamycin
• serious interstitial damage and increased apoptosis 1 week after treatment with adriamycin
|
homeostasis/metabolism
• abnormally increased creatinine levels as a result of adriamycin treatment
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• abnormally increased albuminuria as a result of treatment with adriamycin
|
• increased susceptibility to glomerulopathy in response to adriamycin-induced kidney injury
|
cellular
• increased apoptosis 1 week after treatment with adriamycin
|