All Phenotypes Fmr1<tm2Cgr> MGI Mouse

behavior/neurological

abnormal behavior ( J:104445 )

• at 72 weeks, male mice (106 to 123 CGG repeats) in an open field test travel shorter distances and enter the center circle fewer times than wild-type mice

• however, activity and exploration levels are normal

abnormal learning/memory/conditioning ( J:104445 )

• at 52 weeks, male mice (106 to 123 CGG repeats) in a Morris water maze exhibit impaired visual-spatial learning and memory compared to wild-type mice with increased escape latency and path length

impaired coordination ( J:104445 )

• male mice (106 to 123 CGG repeats) exhibit decreased performance on a rotarod as they age unlike wild-type mice

• at 52 and 72 weeks, male mice (106 to 123 CGG repeats) exhibit reduced latency to fall on a rotarod test compared to at 20 weeks of age

• at 72 weeks, male mice (106 to 123 CGG repeats) exhibit a lower number of segments crossed on a stationary beam compared to wild-type mice

• however, mice perform as wild-type mice in a gait test

decreased grip strength ( J:104445 )

• at 52 weeks, male mice (106 to 123 CGG repeats) exhibit decreased latency to first fall in a wire suspension test and fall more often than wild-type mice

• however, performance in a wire suspension test is normal at 20 and 72 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fragile X-associated tremor/ataxia syndrome		DOID:0050879	OMIM:300623	J:104445

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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