All Phenotypes Jchain<tm1Tl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jchain^tm1Tl
targeted mutation 1, Tomas Leanderson
MGI:2451101

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jchain^tm1Tl/Jchain^tm1Tl	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:3762622

Allelic Composition	Jchain^tm1Tl/Jchain^tm1Tl
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jchain^tm1Tl mutation (0 available); any Jchain mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal humoral immune response ( J:71355 )

• mutant mice were immune competent, however, the serum Ig response was reduced after immunization

increased IgA level ( J:71355 )

• serum IgA elevated 14-fold

decreased IgG level ( J:71355 )

• serum IgG reduced six to eight fold

decreased IgM level ( J:71355 )

• serum IgM reduced six to eight fold