Phenotypes associated with this allele

• Allele Symbol: Jchain^tm1Tl
• Allele Name: targeted mutation 1, Tomas Leanderson
• Allele ID: MGI:2451101
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jchain^tm1Tl/Jchain^tm1Tl	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6	MGI:3762622

Genotype
MGI:3762622

hm1

• Allelic Composition: Jchain^tm1Tl/Jchain^tm1Tl
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal humoral immune response ( J:71355 )

• mutant mice were immune competent, however, the serum Ig response was reduced after immunization

increased IgA level ( J:71355 )

• serum IgA elevated 14-fold

decreased IgG level ( J:71355 )

• serum IgG reduced six to eight fold

decreased IgM level ( J:71355 )

• serum IgM reduced six to eight fold

hematopoietic system

increased IgA level ( J:71355 )

• serum IgA elevated 14-fold

decreased IgG level ( J:71355 )

• serum IgG reduced six to eight fold

decreased IgM level ( J:71355 )

• serum IgM reduced six to eight fold