Phenotypes associated with this allele

• Allele Symbol: Hba-a1^tm1Shs
• Allele Name: targeted mutation 1, Takuji Shirasawa
• Allele ID: MGI:2451238
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hba-a1^tm1Shs/Hba-a1^+	involves: C57BL/6CrSlc	MGI:3762583

Genotype
MGI:3762583

ht1

• Allelic Composition: Hba-a1^tm1Shs/Hba-a1⁺
• Genetic Background: involves: C57BL/6CrSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

anemia ( J:81902 )

• mild anemia

abnormal hemoglobin ( J:81902 )

• the oxygen dissociation of red blood cells shows low affinity for oxygen in vitro

homeostasis/metabolism

increased carbon dioxide production ( J:81902 )

• produce more carbon dioxide in room air and hypoxic conditions

increased oxygen consumption ( J:81902 )

• consume more oxygen in room air and hypoxic conditions

• consume more oxygen in skeletal muscles by oxidative phosphorylation

hyperoxia ( J:81902 )

• enhanced tissue oxygenation

increased aerobic running capacity ( J:81902 )

• run 2.5 times as far as wild-type mice spontaneously on a running wheel

muscle

abnormal skeletal muscle fiber type ratio ( J:81902 )

• show no fiber hypertrophy or atrophy

• on histochemical staining for ATPase, show a higher percentage of type IIA fibers and a lower percentage of type IIB fibers in deep regions of the muscle

cellular

abnormal aerobic respiration ( J:81902 )

• succinate dehydrogenase activities in both type IIA and type IIB muscle fibers are greater in deep regions of the tibialis anterior compared to wild-type mice