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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fancltm1Ceb
targeted mutation 1, Colin E Bishop
MGI:2451263
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fancltm1Ceb/Fancltm1Ceb 129/Sv-Fancltm1Ceb MGI:2660796
hm2
 		Fancltm1Ceb/Fancltm1Ceb either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * FVB/N) MGI:2660795
hm3
 		Fancltm1Ceb/Fancltm1Ceb involves: 129/Sv * C57BL/6 MGI:2660797
ht4
 		Fanclgcd/Fancltm1Ceb involves: 129S7/SvEvBrd * C57BL/6J * CBA MGI:2660784
ht5
 		Fanclgcd/Fancltm1Ceb involves: 129/Sv * C57BL/6 MGI:2660791
ht6
 		Fanclgcd/Fancltm1Ceb involves: 129/Sv * C57BL/6 * FVB/N MGI:2660790


Genotype
MGI:2660796
hm1
Allelic
Composition		 Fancltm1Ceb/Fancltm1Ceb
Genetic
Background		 129/Sv-Fancltm1Ceb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80424 )
• lethality on a 129/Sv background




Genotype
MGI:2660795
hm2
Allelic
Composition		 Fancltm1Ceb/Fancltm1Ceb
Genetic
Background		 either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
impaired ovarian folliculogenesis ( J:80424 )
• few developing follicles
abnormal seminiferous tubule morphology ( J:80424 )
• greater than 90% of the tubules contained vacuolated sertoli cells but no developing germ cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type

reproductive system
decreased male germ cell number ( J:80424 )
• depletion evident at 10.25 dpc
impaired ovarian folliculogenesis ( J:80424 )
• few developing follicles
abnormal seminiferous tubule morphology ( J:80424 )
• greater than 90% of the tubules contained vacuolated sertoli cells but no developing germ cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type
small uterus ( J:80424 )
• uterine horns were pale and thin

cellular
decreased male germ cell number ( J:80424 )
• depletion evident at 10.25 dpc




Genotype
MGI:2660797
hm3
Allelic
Composition		 Fancltm1Ceb/Fancltm1Ceb
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80424 )
• lethality on a mixed background involving 129/Sv and C57BL/6




Genotype
MGI:2660784
ht4
Allelic
Composition		 Fanclgcd/Fancltm1Ceb
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation (0 available); any Fancl mutation (29 available)
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80424 )
• lethality on a 129/Sv background




Genotype
MGI:2660791
ht5
Allelic
Composition		 Fanclgcd/Fancltm1Ceb
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation (0 available); any Fancl mutation (29 available)
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:80424 )
• lethality on a mixed background involving 129/Sv and C57BL/6




Genotype
MGI:2660790
ht6
Allelic
Composition		 Fanclgcd/Fancltm1Ceb
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation (0 available); any Fancl mutation (29 available)
Fancltm1Ceb mutation (0 available); any Fancl mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:80424 )
• >90% of seminiferous tubules contained vacuolated sertoli cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type

reproductive system
absent germ cells ( J:80424 )
• deficiency observed at 10.5 dpc
abnormal Sertoli cell morphology ( J:80424 )
• >90% of seminiferous tubules contained vacuolated sertoli cells
small testis ( J:80424 )
• approximately 1/3 the size of wild-type

cellular
absent germ cells ( J:80424 )
• deficiency observed at 10.5 dpc




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory