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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp1a1tm1Ling
targeted mutation 1, Jerry B Lingrel
MGI:2451290
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp1a1tm1Ling/Atp1a1tm1Ling involves: 129P2/OlaHsd * C57BL/6 * Black Swiss MGI:2451296
ht2
 		Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd MGI:3694084
ht3
 		Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd * Black Swiss MGI:3697482
ht4
 		Atp1a1tm1Ling/Atp1a1+ involves: 129P2/OlaHsd * C57BL/6 * Black Swiss MGI:2451294


Genotype
MGI:2451296
hm1
Allelic
Composition		 Atp1a1tm1Ling/Atp1a1tm1Ling
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:55191 )
• no homozygous offspring are observed




Genotype
MGI:3694084
ht2
Allelic
Composition		 Atp1a1tm1Ling/Atp1a1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle contractility ( J:114415 )
• peak tetanic force produced by extensor digitorum longus (EDL) muscle at supramaximal stimulation is ~240 mN/sq. mm compared to 297 mN/sq. mm in wild-type
• EDL muscle produces similar twitch force to wild-type muscle
• contractility of mutant muscle is increased with ouabain inhibition of Atp1a2
• constant for fatigue is similar to wild-type




Genotype
MGI:3697482
ht3
Allelic
Composition		 Atp1a1tm1Ling/Atp1a1+
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced behavioral response to addictive substance ( J:117414 )
• increase in peak activity elicited by methamphetamine and prolonged habituation time
abnormal locomotor activation ( J:117414 )
• increased swimming speed during hidden platform training in a Morris water maze; however, latency to find the platform is not significantly different from wild-type

homeostasis/metabolism
increased circulating corticosterone level ( J:117414 )
• increase in basal and post methamphetamine challenge serum levels
• however, levels of norepinephrine, dopamine, serotonin, and their metabolites are all similar to wild-type mice




Genotype
MGI:2451294
ht4
Allelic
Composition		 Atp1a1tm1Ling/Atp1a1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a1tm1Ling mutation (0 available); any Atp1a1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:55191 )
• hearts are hypocontractile

muscle
decreased cardiac muscle contractility ( J:55191 )
• hearts are hypocontractile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory