Phenotypes associated with this allele

• Allele Symbol: Rr27^tm1Tilg
• Allele Name: targeted mutation 1, Shirley M Tilghman
• Allele ID: MGI:2451308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr27^tm1Tilg/Rr27^+	involves: 129S1/Sv	MGI:3815532

Genotype
MGI:3815532

ht1

• Allelic Composition: Rr27^tm1Tilg/Rr27⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal imprinting ( J:81888 )

• the imprinting that results in reduced expression of the maternal Igf2 allele is defective in these mice

• the mutation leads to reduced maternal H19 expression and enhanced maternal Igf2 expression

growth/size/body

increased body weight ( J:81888 )

• neonates inheriting a mutant maternal allele are 17% heavier than controls