Phenotypes associated with this allele

• Allele Symbol: Cbl^tm1Wlan
• Allele Name: targeted mutation 1, Wallace Langdon
• Allele ID: MGI:2451336
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cbl^tm1Wlan/Cbl^tm1Wlan	involves: 129S1/Sv * C57BL/6	MGI:2451359

Genotype
MGI:2451359

hm1

• Allelic Composition: Cbl^tm1Wlan/Cbl^tm1Wlan
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:81965 )

• fewer than expected homozygotes are found at weaning

hematopoietic system

enlarged spleen ( J:81965 )

• about a 50% increase in spleen size

spleen hyperplasia ( J:81965 )

• increase in the number of megakaryocytes, megakaryoblasts, and myelocytes mostly located in clusters towards the spleen periphery

myeloid hyperplasia ( J:81965 )

• expansion of cells in the myeloid lineage in the bone marrow

abnormal myeloblast morphology/development ( J:81965 )

• increase in the proportion of ITGAM and LY6G expressing cells and decrease in the proportion of B220+ cells

increased spleen red pulp amount ( J:81965 )

• expanded red pulp resulting in darker spleen color

abnormal T cell physiology ( J:81965 )

• CD5 and CD69 expression (markers of T cell activation) are increased in DP thymocytes although less than in Cbl null mice

immune system

enlarged spleen ( J:81965 )

• about a 50% increase in spleen size

spleen hyperplasia ( J:81965 )

• increase in the number of megakaryocytes, megakaryoblasts, and myelocytes mostly located in clusters towards the spleen periphery

myeloid hyperplasia ( J:81965 )

• expansion of cells in the myeloid lineage in the bone marrow

increased spleen red pulp amount ( J:81965 )

• expanded red pulp resulting in darker spleen color

abnormal T cell physiology ( J:81965 )

• CD5 and CD69 expression (markers of T cell activation) are increased in DP thymocytes although less than in Cbl null mice

reproductive system

dilated oviduct ( J:81965 )

♀ • 40% of females have dilated oviducts without hyperplasia possibly as a result of obstruction and mucous retention

dilated uterus ( J:81965 )

♀ • 40% of females have a dilated uterus without hyperplasia possibly as a result of obstruction and mucous retention

growth/size/body

enlarged spleen ( J:81965 )

• about a 50% increase in spleen size

spleen hyperplasia ( J:81965 )

• increase in the number of megakaryocytes, megakaryoblasts, and myelocytes mostly located in clusters towards the spleen periphery