Phenotypes associated with this allele

• Allele Symbol: Scn2b^tm1Isom
• Allele Name: targeted mutation 1, Lori L Isom
• Allele ID: MGI:2451362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn2b^tm1Isom/Scn2b^tm1Isom	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:2451363

Genotype
MGI:2451363

hm1

• Allelic Composition: Scn2b^tm1Isom/Scn2b^tm1Isom
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:82050 )

• susceptibility to pharmacologically induced seizures

• although nervous system function is generally normal, homozygotes are prone to epileptic seizures induced by pilocarpine

• time to reach stage 3 seizures is significantly reduced

• succeptibility is greater after 10 generations of backcrossing to C57BL/6J as compared to the F2 generation

nervous system

increased susceptibility to pharmacologically induced seizures ( J:82050 )

• susceptibility to pharmacologically induced seizures

• although nervous system function is generally normal, homozygotes are prone to epileptic seizures induced by pilocarpine

• time to reach stage 3 seizures is significantly reduced

• succeptibility is greater after 10 generations of backcrossing to C57BL/6J as compared to the F2 generation

abnormal nervous system electrophysiology ( J:82050 )

• no changes in conductance velocity

• reduced maximal amplitude of sodium current in isolated hippocampal neurons

• is also a reduced negative shift in the voltage dependence of inactivation

• 30-40% reduction in the sodium current in the optic nerve