All Phenotypes Oprm1<tm2.1Loh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oprm1^tm2.1Loh
targeted mutation 2.1, Horace H Loh
MGI:2651420

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm2.1Loh/Oprm1^tm2.1Loh	Not Specified	MGI:3761790

Allelic Composition	Oprm1^tm2.1Loh/Oprm1^tm2.1Loh
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm2.1Loh mutation (0 available); any Oprm1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal touch/ nociception ( J:81978 )

• a naloxone dose-dependent antinociceptive response that was not observed with wild-type

• when the mice was treated chronically with naltresone, tolerance to the drug including morphine was not observed

• effect of morphine antinociception was not different from wild-type control

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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