Phenotypes associated with this allele

• Allele Symbol: Prkacb^tm2Gsm
• Allele Name: targeted mutation 2, G Stanley McKnight
• Allele ID: MGI:2651519
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkacb^tm2Gsm/Prkacb^tm2Gsm	B6.129X1-Prkacb^tm2Gsm	MGI:3611774
hm2	Prkacb^tm2Gsm/Prkacb^tm2Gsm	involves: 129X1/SvJ * C57BL/6	MGI:2651525

Genotype
MGI:3611774

hm1

• Allelic Composition: Prkacb^tm2Gsm/Prkacb^tm2Gsm
• Genetic Background: B6.129X1-Prkacb^tm2Gsm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:78451 )

N • Background Sensitivity: cued fear condition responses are similar to wild-type, unlike homozygous mice on a mixed 129X1/SvJ C57BL/6J background

Genotype
MGI:2651525

hm2

• Allelic Composition: Prkacb^tm2Gsm/Prkacb^tm2Gsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

behavior/neurological

abnormal cued conditioning behavior ( J:78451 )

• Background Sensitivity: homozygotes on a mixed 129X1/SvJ C57BL/6 background have 39% and 30% reductions in freezing response to a tone 2 and 24 hours, respectively, after cued fear training; however, on a 98% C57BL/6 cued fear responses are normal

nervous system

abnormal nervous system physiology ( J:78451 )

• a 26% decrease in basal cAMP-dependent protein kinase (PKA) levels is seen in the amygdala, hippocampus, and cortex relative to wild-type controls; however total PKA activity (with the addition of cAMP) in these areas is similar to wild-type