mortality/aging
• in embryos after E7.5, yolk sacs contained partially degenerating or fully resorbed embryos
|
embryo
• abnormal gastrulation with no clear evidence of embryonic mesoderm and endoderm
|
• embryos were substantially smaller than wild-type embryos (E6.5)
|
• abnormally developed trophectoderm
|
• trophoblast cells have small nucleii; despite high levels of nuclear cyclin E in these cells, no S-phase cells were detected
|
absent amnion
(
J:57761
)
• greatly elevated frequency of cells in S-phase
|
• absence of the extraembryonic cavities
|
growth/size/body
• embryos were substantially smaller than wild-type embryos (E6.5)
|