Phenotypes associated with this allele

• Allele Symbol: Gpx4^tm1Prol
• Allele Name: targeted mutation 1, Tomas A Prolla
• Allele ID: MGI:2651590
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx4^tm1Prol/Gpx4^tm1Prol	involves: 129 * C57BL/6J	MGI:2651591
ht2	Gpx4^tm1Prol/Gpx4^+	involves: 129	MGI:2651598
ht3	Gpx4^tm1Prol/Gpx4^+	involves: 129 * C57BL/6J	MGI:2651593

Genotype
MGI:2651591

hm1

• Allelic Composition: Gpx4^tm1Prol/Gpx4^tm1Prol
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:82053 )

• embryos die around E7.5

embryo

abnormal germ layer development ( J:82053 )

failure to gastrulate ( J:82053 )

Genotype
MGI:2651598

ht2

• Allelic Composition: Gpx4^tm1Prol/Gpx4⁺
• Genetic Background: involves: 129

normal phenotype

no abnormal phenotype detected ( J:82053 )

• Background Sensitivity: gamma-irradiation did not affect survival of mice on a 129/Sv genetic background

Genotype
MGI:2651593

ht3

• Allelic Composition: Gpx4^tm1Prol/Gpx4⁺
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

increased mortality induced by gamma-irradiation ( J:82053 )

• reduced survival on mixed 129/Sv and C57BL/6 genetic background relative to control littermates

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:82053 )

• reduced survival on mixed 129/Sv and C57BL/6 genetic background relative to control littermates