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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pigrtm1Fejo
targeted mutation 1, Finn-Eirik Johansen
MGI:2651657
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pigrtm1Fejo/Pigrtm1Fejo involves: 129 * C57BL/6 MGI:4353909
hm2
 		Pigrtm1Fejo/Pigrtm1Fejo involves: 129P2/OlaHsd * C57BL/6 MGI:2651658
ht3
 		Pigrtm1Fejo/Pigr+ involves: 129 * C57BL/6 MGI:4353910


Genotype
MGI:4353909
hm1
Allelic
Composition		 Pigrtm1Fejo/Pigrtm1Fejo
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Fejo mutation (2 available); any Pigr mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased IgA level ( J:140515 )
• IgA levels are 50-fold higher in the serum than in controls
• G. lamblia infection leads to a large increase parasite specific IgA levels compared to infected wild-type controls
increased susceptibility to parasitic infection ( J:140515 )
• mice are more susceptible to Giardia muris infection compared to controls
• seven weeks after infection, mice have over 1,000-fold higher trophozoite numbers in the small intestine compared with controls
• fecal cyst shedding is also significantly higher
• mice are able to eradicate infection with the GS/M strain of G. lamblia that can infect humans

digestive/alimentary system
abnormal digestive secretion ( J:140515 )
• mice have 10-fold lower fecal levels of IgA than in controls
• G. lamblia infection leads to 2-fold increase of IgG in the fecal matter

hematopoietic system
increased IgA level ( J:140515 )
• IgA levels are 50-fold higher in the serum than in controls
• G. lamblia infection leads to a large increase parasite specific IgA levels compared to infected wild-type controls




Genotype
MGI:2651658
hm2
Allelic
Composition		 Pigrtm1Fejo/Pigrtm1Fejo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Fejo mutation (2 available); any Pigr mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgA level ( J:57987 )
• IgA concentrations at the mucosal surface in the small intestine and in fecal extracts are decreased
increased IgA level ( J:57987 )
• increase in levels of IgA in serum; only polymeric forms of IgA are seen
increased IgG level ( J:57987 )
• increase in serum IgG levels, including antibodies to E. coli but not Lactobacillus or gluten
• IgG levels are increased in the saliva
• small intestinal IgG levels are 2-fold higher than in wild-type
abnormal immunoglobulin transcytosis ( J:57987 )
• mutants have more interstitial IgA in the lamina propria of the small intestine than wild-type mice while no IgA is seen in the epithelium, indicating lack of intracellular IgA transport despite increased concentration of subepithelial IgA
• lack of IgM epithelial transport in the small intestine
• no vesicular IgA transport through hepatocytes

digestive/alimentary system
abnormal intestine physiology ( J:57987 )
• increase in mucosal leakiness, however, intestinal mucosa shows no signs of inflammation

homeostasis/metabolism
abnormal homeostasis ( J:57987 )
• defective epithelial barrier function as indicated by increased albumin levels at mucosal surfaces (in saliva and feces), reflecting epithelial leakage of serum proteins

reproductive system
reproductive system phenotype ( J:57987 )
N
• mice exhibit normal fertility

hematopoietic system
decreased IgA level ( J:57987 )
• IgA concentrations at the mucosal surface in the small intestine and in fecal extracts are decreased
increased IgA level ( J:57987 )
• increase in levels of IgA in serum; only polymeric forms of IgA are seen
increased IgG level ( J:57987 )
• increase in serum IgG levels, including antibodies to E. coli but not Lactobacillus or gluten
• IgG levels are increased in the saliva
• small intestinal IgG levels are 2-fold higher than in wild-type




Genotype
MGI:4353910
ht3
Allelic
Composition		 Pigrtm1Fejo/Pigr+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pigrtm1Fejo mutation (2 available); any Pigr mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive secretion ( J:140515 )
• fecal levels of IgA are half that of wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory