Phenotypes associated with this allele

• Allele Symbol: Pigr^tm1Rast
• Allele Name: targeted mutation 1, Richard A Strugnell
• Allele ID: MGI:2651659
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pigr^tm1Rast/Pigr^tm1Rast	C57BL/6-Pigr^tm1Rast	MGI:2651661

Genotype
MGI:2651661

hm1

• Allelic Composition: Pigr^tm1Rast/Pigr^tm1Rast
• Genetic Background: C57BL/6-Pigr^tm1Rast

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immunoglobulin level ( J:81984 )

decreased IgA level ( J:81984 )

• intestinal IgA levels are reduced

increased IgA level ( J:81984 )

• 100-fold increase in dimeric serum IgA levels

increased IgG level ( J:81984 )

• slight elevation in intestinal IgG levels

abnormal immune system cell morphology ( J:81984 )

• increase in the number of IgA antibody secreting cells (ASC) in the intestinal lamina propria, spleen and mesenteric lymph nodes

abnormal immunoglobulin transcytosis ( J:81984 )

• mutants are unable to secrete dimeric IgA into the mucosal lumen and thus accumulate polymeric IgA in serum

digestive/alimentary system

abnormal intestine morphology ( J:81984 )

• 2-fold increase in blast cell populations in the intestinal lamina propria

hematopoietic system

abnormal immunoglobulin level ( J:81984 )

decreased IgA level ( J:81984 )

• intestinal IgA levels are reduced

increased IgA level ( J:81984 )

• 100-fold increase in dimeric serum IgA levels

increased IgG level ( J:81984 )

• slight elevation in intestinal IgG levels