Phenotypes associated with this allele

• Allele Symbol: Tg(K5-Ptgs2)667Kmd
• Allele Name: transgene insertion 667, Karin Muller-Decker
• Allele ID: MGI:2651675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(K5-Ptgs2)667Kmd/0	involves: NMRI	MGI:2651742

Genotype
MGI:2651742

tg1

• Allelic Composition: Tg(K5-Ptgs2)667Kmd/0
• Genetic Background: involves: NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

mortality/aging

premature death ( J:79071 )

• die at 10 months of age

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:70039 )

• sebaceous gland hyperplasia

• most pronounced in dorsal and tail skin

increased sebaceous gland adenoma incidence ( J:79071 )

• sebaceous gland adenomas

neoplasm

increased sebaceous gland adenoma incidence ( J:79071 )

• sebaceous gland adenomas

increased incidence of tumors by chemical induction ( J:79071 )

• increased incidence of skin tumors after DMBA initiation and promotion by twice-weekly treatments

increased skin papilloma incidence ( J:79071 )

increased squamous cell carcinoma incidence ( J:79071 )

• squamous cell carcinomas

homeostasis/metabolism

increased prostaglandin level ( J:70039 )

• increased prostaglandin levels

increased incidence of tumors by chemical induction ( J:79071 )

• increased incidence of skin tumors after DMBA initiation and promotion by twice-weekly treatments

integument

sebaceous gland hyperplasia ( J:70039 )

• sebaceous gland hyperplasia

• most pronounced in dorsal and tail skin

increased sebaceous gland adenoma incidence ( J:79071 )

• sebaceous gland adenomas

abnormal coat/ hair morphology ( J:70039 )

abnormal coat appearance ( J:70039 )

• at 7 weeks of age fur appeared sparse, greasy, and coarse

• hair phenotype most severe on the back

alopecia ( J:70039 )

• hairless at 8 days of age

sparse hair ( J:70039 )

coarse hair ( J:70039 )

abnormal nail morphology ( J:70039 )

long toenails ( J:70039 )

abnormal hair follicle development ( J:70039 )

• delayed hair follicle maturation

abnormal hair follicle orientation ( J:70039 )

• hair follicles oriented perpendicular to skin

decreased hair follicle number ( J:70039 )

abnormal dermal layer morphology ( J:70039 )

• increased blood vessel density in upper dermis

hyperkeratosis ( J:70039 )

• epidermal hyperkeratosis of the tail

epidermal hyperplasia ( J:70039 )

• epidermal hyperplasia of the tail

thin skin ( J:70039 )

increased skin papilloma incidence ( J:79071 )

limbs/digits/tail

long toenails ( J:70039 )