Phenotypes associated with this allele

• Allele Symbol: Gfra3^tm1Adav
• Allele Name: targeted mutation 1, Alun M Davies
• Allele ID: MGI:2651728
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfra3^tm1Adav/Gfra3^tm1Adav	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1	MGI:2651729

Genotype
MGI:2651729

hm1

• Allelic Composition: Gfra3^tm1Adav/Gfra3^tm1Adav
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:71959 )

• at E14, a significantly smaller proportion of sympathetic neuroblasts undergo mitosis in the SCG of mutant embryos relative to wild-type embryos

abnormal superior cervical ganglion morphology ( J:71959 )

• at E14, mutant superior cervical ganglia (SCG) are more caudally located than wild-type SCG

small superior cervical ganglion ( J:71959 )

• at E14, mutant SCG are smaller than wild-type SCG

• notably, the proportion of beta-III tubulin-positive cells that are PCNA-positive in mutant SCG is half that observed in wild-type embryos, indicating a significant reduction in the rate of neuroblast proliferation in mutant sympathetic ganglia

cellular

abnormal neuronal precursor proliferation ( J:71959 )

• at E14, a significantly smaller proportion of sympathetic neuroblasts undergo mitosis in the SCG of mutant embryos relative to wild-type embryos